Every now and then, you hear news of people dying due to heart attack and high blood pressure related condition. This is why the current mortality rate provokes a silent panic for people in their 40s and up. Remember that high blood pressure is a silent killer due to the absence of notable symptoms. But it does not mean you cant do something to prevent and control it to live a longer life.
In a study published in Time Healthland in March of this year one of the conclusions was that the longer one continued working the longer one would live. However it is wrong to assume that medical advances will save you from an early death.
Today, you can find a lot of health supplements that are made from natural ingredients or synthetic ones that readily available in the market. And although there are plenty of natural supplements, nothing can compare with the innovations and benefits of resveratrol. This anti aging supplement is usually associated with red wines or grapes. It is because, red grapes are being used to making red wine, which contains resveratrol, an antioxidant known to help lower high blood pressure level and is believed to promote good health. H
Resveratrol was first discovered way back the 1940s, in the roots of a plant named Veratum Grandiflorum. It was later found out that red grapes also contain this substance and can be found in wines. It is identified as a phytoalexin, which basically means it contains antibiotic properties naturally produced by plants to respond to any disease-producing substance. Studies later showed that among the astounding resveratrol benefits include anti-inflammatory, anti-platelet, anti-cancer, anti-mutagenic, and anti-fungal.
Besides having great effect in lowering high blood pressure level, another benefit is believed to treat arthritis and rheumatism. Studies suggest that resveratrol effectively inhibit the expression of MMp-3, VEGF, MMP-9 and COX-2 to suppress inflammation. This is the reason why, for severe cases of arthritis, intra-articular injections of resveratrol are given out to prevent further damage to the cartilage.
Additional information about resveratrol benefits has something to do with diabetes. Studies suggest that it has been found out to decrease the secretion of insulin and delay the onset of insulin resistance, which most severe diabetes sufferers eventually develop. Also, it is now being used to treat fatty liver and pancreatitis.
Anti aging antioxidants are molecules that have the purpose of slowing or preventing oxidation in other molecules. The antioxidants that people hear about most are the ones that affect our bodies. These particular antioxidants can slow down the process of aging in the body and can reduce the number of free radicals in the body.
Anti aging antioxidants work by the chemical reactions taking place between the substance and the oxidizing agent. When oxidation occurs in the body, the body builds up the number of free radicals. These free radicals can begin a chain reaction that ends with the damage of your cells. An antioxidant introduced into this situation will stop the chain reaction between the oxidizing agent and the cell, remove the free radicals, and inhibit the oxidization of other chain reactions.
Some common anti aging antioxidants are vitamin C, vitamin E, Resveratrol and other enzymes found naturally in the biology of plants and animals. All living beings must maintain balance of antioxidants in their system in order for the system to work properly. If a plant or animal has a really low level of antioxidants in the system, there will be oxidative stress present as well as evidence of damaged and dying cells.
Researchers studying antioxidants have found that oxidative stress is present in many human diseases, but it is still being studied as to whether the oxidative stress is caused by the disease, or causes the onset of the disease. Though the cause is unclear, the effect of antioxidants used in the treatment of strokes and neurodegenerative diseases is proof that antioxidants do work in order to help restore the body.
For those who are healthy, it is still good to be aware of what antioxidants do for the body and how everyone can improve their health with antioxidants. Antioxidants are found in foods such as fruits, vegetables, and green tea. Taking in a good amount of antioxidants such as resveratrol daily will not only keep you healthy, but it may also work to reduce the signs of aging. These compounds rejuvenate your body at the cellular level, so if you have been taking in enough antioxidants into your body, you will find that you are aging at a much slower rate than a person who is an unhealthy eater, who smokes regularly, and those who are not getting enough sleep or exercise.
Learning about the benefits of antioxidants can help improve your life. If you want to begin to reduce the signs of aging, make sure that you are eating healthy and maintaining a regular exercise routine and sleep patterns.
Resveratrol, a substance found predominantly in red wine, as well as peanuts, pine trees, Japanese Knotweed and cocoa, has been touted as a significant contributor to overall health, and recently as a preventer of hair loss. Since hair loss is attributed to several things, including inflammation and cell death, resveratrol's ability to inhibit these effects makes it useful for hair re growth or prevention of hair loss.
Resveratrol is a Polyphenol found predominantly in grapes, especially the skin and seed. In the past decade, resveratrol has gained attention in the medical and alternative medicine communities as it is a powerful antioxidant and also a polyphenol, which means it comes from a class of organic plant compounds having more than one phenol group.
Red wine has been found to have health benefits because of its resveratrol content. The substance is also found in other things, but grapes are known to have higher quantities. However, its concentration can be amplified greatly in supplement form. Since it's not recommended to drink more than a glass or two of wine a day, a resveratrol supplement is the best method for obtaining its benefits, coming in both liquid and pill form.
Resveratrol has been found to prevent or reverse cell death. Hair loss is attributed to hair cell apoptosis, which is programmed cell death. This cell death executes apoptosis Protein Kinase C isozymes, which kill cells and lead to hair loss. Resveratrol is a known inhibitor of PKC, according to hair loss-research.org.
Inflammation is a known degenerative factor to aging and health. Proven to be a cause of androgenetic alopecia, the prevention and halting of inflammation greatly improves the many conditions of disease. Resveratrol has been shown to inhibit inflammation on a cellular level, and is being used in hair re growth and hair loss prevention treatments.
One of the most recent discoveries is on using resveratrol combined with curcumin to stimulate hair growth. With resveratrol's anti-inflammatory properties and curcumin's ability to inhibit the compound TGF-B (an inflammatory cytokine directly associated with balding), the two substances together have been found to be beneficial in hair loss prevention and re growth. This combination is being patented in Italy.
Resveratrol has been shown not only to reduce the risk of developing wrinkles, but can reduce the appearance of wrinkles that have developed within the skin, whether these are fine lines or deeper.
Resveratrol which is used within a variety of these wrinkle creams and skin care regimens is derived from the skin of red grapes, the ingredient that causes wine to become such an effective antioxidant for the skin. The skin of the red grapes contains a higher antioxidant level, however, than red wine nearly ten times more. Resveratrol extracts are derived from the grape skins and than combined with a variety of other ingredients that are used to create effective anti-aging skin care routines.
Resveratrol works on two levels of skin care. There are combination's of the extract which are used within vitamins to create younger appearing skin, from the inside out, as well as topical treatments which contain the extract which work on the surface of the skin. Within these two forms of skin care, there are aspects to each which enable certain advantages and disadvantages to the methods in which these are applied to the skin.
The advantages of using a topical treatment is the ease of use and the instant gratification that can come from applying the topical lotions, ointments or any-wrinkle creams to the skin. The skin can often instantly appear to have a glow and appear supple and moisturized. While there are certain advantages to using topical creams that contain resveratrol, there are certain disadvantages that come with it as well. Only the first two layers of the skin can be reached through this type of application and therefore it can be hard for the topical treatments to encourage the production of collagen or elastin.
Resveratrol Supplements are often taken on a daily basis, one to two times per day and contain high levels of antioxidant ingredients, aside from resveratrol. These ingredients can cleanse the body from toxins while improving the overall appearance of the skin. The ingredients which are used within these toxins can be used to cleanse the bodily system and remove the chemicals from the body which can lead to poorly kept skin, and the formation of wrinkles and lines. While the antioxidants are increased within the body, the skin can be stimulated to form higher levels of collagen and elastin, increasing the potential to have younger appearing skin.
By including resveratrol into the skin to reduce the signs of aging and to promote the prevention of wrinkles, you can also ensure that the body health is maintained, which is a key component to maintaining healthy skin. There have been many experts that have speculated the appearance of our bodies can be directly linked to the state of our health, therefore, ensuring that you are consuming high levels of antioxidants and vitamins can improve the health of your skin and reduce the signs of aging.
Inflammation has become one of the hottest topics in medical research because it is emerging as a possible cause of so many of the chronic diseases that threaten the quality and the length of life. Addressing inflammation could be a singular approach to targeting multiple health conditions and, perhaps, could simplify scientific and medical research strategies for fighting many of the most deadly chronic diseases.
We now know that there are many possible lifestyle and environmental triggers of inflammatory stress, including smoking; a high-fat, high-carbohydrate diet; obesity; radiation; and even exposure to environmental toxins. Persistent, chronic, or uncontrolled low-grade inflammation has been linked to increased risk for the metabolic syndrome and heart disease, diabetes and insulin resistance, rheumatoid arthritis, certain cancers, asthma, allergies, and even Alzheimers disease.
Acute inflammation is a natural immune system response to injury or infection during which the body orchestrates a symphony of immune system signals, messages, and physiological actions to combat and neutralize foreign invaders that may be responsible for the injury. This inflammatory response can result in the characteristic redness, heat, swelling, and pain that you may see and feel at the site of a wound and is the beginning of the healing process as the body eventually brings nourishment to the site.
Most of the time, inflammation is an acute, on-demand function, a biological stress response that enables our body to fight off disease-causing bacteria, viruses, and parasites. But when inflammation doesnt shut down on cue, or somehow persists with no particular purpose, it can attack normally healthy cells and cause damage at the cellular level. In autoimmune diseases, a continuously triggered inflammatory response causes damage to its own tissuessometimes with disastrous health consequences
Recent research has uncovered the benefits of smoking cessation and even moderate exercise as sound approaches to battling inflammatory stress. A September 2010 laboratory study found that a three-week moderate exercise regimen reduced several biomarkers of inflammatory stress, including C-reactive protein (CRP) in diabetic rats, (onlinelibrary.wiley.com/doi/10.1111/j.1365-2249.2010.04240.x/abstract). The investigators concluded that moderate physical exercise had significant anti-inflammatory effects and that this may be a good strategy to protect against insulin resistance and vascular complications in diabetics.
Nutritional approaches to reducing inflammatory stress are also receiving more attention. Several studies have supported the benefits of a Mediterranean or an anti-inflammatory type diet, and spices such as ginger and turmeric are also showing promise. In the 2010 review Dietary polyphenols can modulate the intestinal inflammatory response, plant sources of dietary polyphenolsincluding green tea extract, various flavonoids, ellagic acid (found in muscadine grapes and pomegranates), and Resveratrol (found in red wine and Japanese knotweed)were shown to successfully modulate intestinal inflammatory response. The investigators concluded that the use of natural preventive treatments in early life could reduce or delay inflammatory bowel diseases, and that polyphenols could play an important role in modulating intestinal inflammation (onlinelibrary.wiley.com/doi/10.1111/j.1753-4887.2009.00210.x/abstract).
In February 2011, a new study, A resveratrol and polyphenol preparation suppresses oxidative and inflammatory stress response to a high-fat, high-carbohydrate meal, was published online in the Journal of Clinical Endocrinology and Metabolism. The researchers from the State University of New York at Buffalo (SUNY) showed that a resveratrol and muscadine grape polyphenol blend was able to suppress the oxidative and inflammatory stress response typically experienced after consumption of a high-fat fast food meal (jcem.endojournals.org/cgi/content/abstract/jc.2010-1812v1).
This peer-reviewed and published human study is even more compelling because it is one of the earliest placebo-controlled clinical research studies on resveratrol compounds. In fact, a January 2011 review of resveratrol research published in the Annals of the New York Academy of Sciences found only six recently completed clinical trials on resveratrol supplementation, and only one other study employed a placebo-controlled design (onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.2010.05853.x/abstract).
In the SUNY study, the researchers fed 10 healthy adults either the resveratrol-muscadine polyphenol blend or a placebo before the high-fat fast food meal, and markers of oxidative and inflammatory stress were measured for five hours following the meal. In the group consuming the polyphenol blend, there was a significant reduction in the oxidative stress response typically observed after consumption of a high-fat meal. At three hours, there was also a 150% increase in Nrf-2, an important regulator of the bodys antioxidant defense and detoxification systems.
The investigators also reported a significant blunting of the bodys inflammatory response to eating a high-fat fast food meal in the subjects who consumed the resveratrol-muscadine polyphenol blend. Induction of two well-known inflammatory biomarkers, plasma lipopolysaccharide and IL-1ß, were both significantly reduced after consuming the high-fat meal, but only in the supplement group.
So what are we to do to address the chronic low-grade inflammation that permeates our modern-day lifestyles? Fortunately, many of the same dietary and lifestyle behaviors weve recommended for decades to lower the risk for cardiovascular diseases and cancer can also help to reduce the risk for chronic inflammation:
Find an exercise you like and participate on a regular basis
Reduce stress and keep your blood pressure in check
Achieve and maintain a healthy weight, which can reduce inflammation, a biological stress response
Dont smoke and avoid secondhand smoke
Eat a healthful diet rich in plant foods, whole grains, legumes, leafy vegetables, colorful fruits, lean cuts of meats and poultry, and low-fat dairy products
Choose unprocessed foods low in trans fats, saturated fat, salt, and sugar
Seek out anti-inflammatory foods such as fish that are rich in omega-3 fatty acids, as well as olive oil
Look for anti-inflammatory nutritional ingredients such as resveratrol, muscadine, and pomegranate polyphenols, as well as spices such as ginger and turmeric
For information about inflammation and your health, talk with your doctor or health care professional to discuss the steps you can take maximize your anti-inflammatory diet and lifestyle.
Resveratrol is a healthier anti-inflammatory alternative to Glucocorticosteroids
In addition to its other beneficial effects such as anti aging , resveratrol has been found to produce anti-inflammatory actions in the body. These actions could potentially influence treatments of inflammatory diseases, including:
Chronic obstructive pulmonary disease (COPD)
Asthma
Allergies
Autoimmune disease
Arthritis
Resveratrol Anti-Inflammatory Studies
Researcher Louise Donnelly at the Imperial College in London studied that anti-inflammatory properties of resveratrol. With her team, she looked at the manner in which resveratrol affects human airway epithelial cells, which were obtained from normal lung cells in the lab.
The researchers found resveratrol to have novel anti-inflammatory properties that were not the result of steroid production or action. Without causing the body to synthesize steroids, resveratrol appears to have the same effect on cells as the glucocorticosteroids with which asthmatics and other suffers of autoimmune disease are familiar.
The Downside of Glucocorticosteroids
Glucocorticosteroids may be an effective treatment for many disease sufferers, but they have upsetting side effects.
Long-term use of glucocorticosteroids can can result in the following side effects:
Inhibited bone formation
Decreased healing factors
Immune system suppression
Increased the risk of infection
Reported muscle weakness
Accordingly, other therapies that do not cause such serious side effects would be preferable for many patients.
Interestingly enough, the resveratrol research also revealed that resveratrol does not work by influencing the glucocorticoid or estrogen receptors.
Glucocorticoid medications work by binding their receptor and forming a complex that moves into the cell and then into the nucleus, where it alters the expression of certain genes. This process is often referred to as trans activation. The cell then begins producing different proteins or different amounts of certain proteins.
Glucocorticoids also induce an opposite process. When they bind to a hormone receptor on the outside of a cell, they prevent the transcription of some genes and reduce the amount of pro-inflammatory proteins produced at the cellular level.
Since resveratrol works via another biological pathway, it could feasibly help in the treatment of diseases that do respond well to steroid treatment. Such diseases include steroid-resistant asthma and arthritis.
Resveratrol has been shown to extend life in yeast and lower animals because of its antioxidant and anti-inflammatory properties. Moreover, it seems that resveratrol suppresses inflammation in human beings. This assumption has been made based on the results that have been obtained from the initial prospective human trial of the extract that has been conducted by the University at Buffalo endocrinologists. The result of the study that has been carried out has appeared as a rapid electronic publication in the Journal of Clinical Endocrinology & Metabolism web site.
When a number of plants are under attack by pathogens, like fungi or bacteria, the compound, resveratrol, is produced naturally. It can be found in red wine as well as in the skin of red grapes. Moreover, it is produced through chemical synthesis that derived mainly from Japanese Knotweed. Additionally, it is sold like a nutritional supplement.
In accordance to Husam Ghamin, a PhD, who is a UB research assistant professor of medicine in addition to being the senior author of the study, resveratrol has been demonstrated to extend life other than bringing a reduction in the rate of aging in yeast, fruit flies and roundworms. These actions are thought to be influenced by an increased in the expression of a specific gene that is linked with longevity.
Besides, the compound is considered to play a part in the resistance of insulin as well. This condition is associated with oxidative stress which has a considerable damaging impact on health in general.
One of UB eminent professor of medicine, Paresh Dandona, MD, PhD, who is also a leading author of the study, says that since there is no illustrating impact of resveratrol on oxidative and inflammatory stress in human beings. He explains that they decided to verify if there is the possibility that the compound can bring a reduction in the level of oxidative as well as inflammatory stress in man.
He adds that several of the main mediators of insulin resistance are pro-inflammatory as well. They therefore examined the impact of resveratrol on the way they express themselves.
The study which was directed by Dandona was carried out at Kaleida Healths Diabetes-Endocrinology Center of Western New York.
A nutritional complement that contained 40 milligrams of resveratrol was made used of as the active product. Twenty random participants were categorised in two groups of ten. One of the two groups was given the supplement. On the other hand, the other group was given a similar pill but containing no active ingredient. The participants were given the pill once on a daily basis for a period of six weeks. Fasting blood samples were gathered at the beginning of the trial as well at week one, three and finally six.
The results demonstrated that resveratrol was able to suppress the generation of free radicals or reactive oxygen species. The later is also referred to as being unstable molecules that are famous for causing oxidative stress and hence discharge pro-inflammatory factors in the blood stream. As a consequence, this results in harm to the blood vessel lining.
The blood samples that were gathered from the people who were taking the resveratrol also confirmed that it suppressed inflammatory protein tumour necrosis factor (TNF) in addition to likewise compounds that leads to a rise in the inflammation of blood vessels and cause interference in insulin action, thus leading to insulin resistance and the probability of developing diabetes.
As Dandona noted, over the long term, these inflammatory factors have an effect on the growth of type 2 diabetes, stroke, heart disease and aging.
On the other hand, the blood samples that were taken for the persons who received the pill without the resveratrol demonstrated no alteration in these pro-inflammatory markers.
Even though these results are quite promising, Dandona included a note of caution; the study that was conducted did not eradicate the probability that something found in the extract other than resveratrol was accountable for the anti-inflammatory effects.
He adds that the product that they used contained a mere 20 percent of resveratrol. Therefore, there is the possibility that something else in the preparation might be accountable for the optimistic effects. It is even possible that these agents are more powerful than resveratrol. They acknowledge that purer preparations are nowadays available and they do intend to test them.
8. Cactus Juice Nopal Cactus Juice Fights inflammation to free you from pain
Many people do not realise that sleepless nights can be caused by inflammation and people who take Nopal cactus juice on a daily basis report they sleep more soundly.
Rubin Naiman, sleep specialist and clinical assistant professor of medicine at the University of Arizonas Enter for Integrative Medicine, points to a whack of research that links sleep debts to a rise in cortisol levels and inflammation biomarkers. And it goes both ways. Sleeplessness increases chronic inflammation, Naiman says, but chronic inflammation also increases sleeplessness. Our bodies should do exactly what the planet does when the sun goes down, says Naiman. All of the heat absorbed during the day should dissipate and steadily decrease throughout the night before reaching its lowest point just before the dawn and coming back up, he says. Sleep is a release of energy. Scientists have found, though, that people suffering from sleep disorders dont get cool enough at night because theyre inflamed. In some cases, their body temperature literally qualifies as a fever state (over 37ºC), says Naiman.
Here are a few tips for those who suffer from the occasional bout of insomnia and are looking for ways to get a better nights sleep:
Cool the room: Lower your thermostat at night to around 20 C.
Turn off the TV: A little TV humour is okay before bed, but avoid being dramatized by one-hour police shows or murder mysteries. Save those for the day, says Naiman. At night you want to create a release of energy, not a buildup.
Unplug your brain: Dont take or make any phone calls or fire off any emails one hour before sleep.
Prep for rest: Use your pre-sleep hour to read a book or practice simple relaxation techniques like meditation and gentle yoga.
Set your alarm: Move your clock to somewhere you can hear it, but not see it. And if your clock has a digital display, ditch it. Even the small amount of light from clock radios can trickle through closed eyelids, suppressing melatonin production and disrupting sleep, says Naiman.
Resveratrol supplements are the supplements which is made of complex compound resveratrol extract ( an extract of the red wine) and essential trace elements like minerals. Resveratrol is one of the most potent anti oxidants till date, it is in the same genre of ECGC which is very effective to tackle the aging process, wrinkles and also very complex diseases like Diabetes type-1. Resveratrol is generally found in the skins of berries and grapes. Resveratrol was firstly extracted from the Japanese Knotweed.
Resveratrol extract has numerous health benefits. It encourages a healthy longer life without any side effects. Resveratrol is better known as an anti aging agent Resveratrol supplement also helps to lose weight
Many believe that resveratrol may have anti-aging properties, anti-inflammatory, and anti-cancer characteristics. More research on this antioxidant agent has shown that it can help prevent heart disease and cancer. It has been found that resveratrol is very effective in treating pancreatic cancer.
Resveratrol is also known for fighting free radicals produces in the body. It also rejuvenates the blood vessels and effectively cause absorption of glucose without elevating blood glucose levels. High levels of glucose in the blood may experience cellular damage and develop retinopathy, kidney disease, and heart disease.
A new study says that Resveratrol may not only reduce the risk of heart disease but also age-related illnesses like Alzheimers disease.
Resveratrol also tackles arthritis, other auto immune diseases, it triggers the action of the antigens that fight the anti bodies in the body mechanism.Resveratrol is also good for reducing wrinkles.
Resveratrol compound is believed to mimic the same effects as that of a calorie-restricted diet that further extends the life span. Fewer calorie intakes trigger sirtuins that are a kind of proteins that regulate metabolism. It has been proved by the researchers that many natural substances can activate sirtuins and Resveratrol does it with great finesse.
However, a word of caution has been given by the scientists as the results have only been seen on animals and it is not necessary that it would work for humans the same way. Also, experiments made until now are based on impractical resveratrol consumption. While one study involved drinking of 100 red wine bottles daily, a later study reduced this number to 35 bottle everyday. Hence, researchers are making efforts to determine what can be called as the manageable dose?
Though Resveratrol has been given the status of the investigational new drug but the approval of FDA for its safety for human consumption is still pending. Many clinical studies are being conducted nowadays that are soon expected to qualify Resveratrol for FDA approval.
Some resveratrol formulas and resveratrol complexes products are available that do not mention the Resveratrol amount contained in it. Supplements usually suggest anywhere between 1-100 milligrams Resveratrol everyday. However, you must take note of the Resveratrol amount in products carefully as there are a few products that mention the amount in micrograms, instead of milligrams. This may seem to be a huge quantity but it actually is not as 1000 micrograms stand equivalent to one milligram.
There doesnt seem to be any serious side effects from Resveratrol consumption, some people may have to diarrhoea and other such minor problems. But pregnant women and children must consult a doctor, if they are considering taking Resveratrol. Some manufacturers suggest its not suitable for children
Famous Physician of Oprah, Dr. Mehmet Oz and Dr. Joseph Maroon along with several scientists and distinguished professors and physicians have advised Resveratrol to be a part of your everyday regime. A dosage between 250mg-500mg of the Trans-Resveratrol is suggested as the daily dosage by Dr. Maroon in a book written by him, to ensure sound health for a long time.
So, if you also wish to benefit from this natural wonder, be sure to check for updates on Resveratrol and make it a habit with you to take it daily, without fail.
While there are many perks to growing older, no one enjoys the negative side effects. As people age, the body slows down, energy levels fall, and overall appearance begins to suffer. However, thanks to the wonders of modern science, that no longer has to be the case with pure resveratrol.
As a weight reducer, previous studies utilizing lab rats concluded that an extra high Resveratrol dosage, equivalent to 1500 bottles of wine, was efficient at preventing the harmful effects of a high calorie diet. However, one recent study suggests that approximately 350 mgs/day is adequate to create a gene profile which closely emulates a caloric-restricted diet.
For many years the substance resveratrol has been studied by scientists. Resveratrol has known anti-inflammatory properties. Many claim that it improves memory and brain function. Resveratrol has also been shown to reduce blood sugar level, make weight loss easier by increasing metabolism, and lower cholesterol. High levels of resveratrol must be present for these effects. This has people searching for a reliable source which is easy to consume.
This powerful preservation process can now be extended to humans as well. Thanks to scientific achievements, resveratrol reviews on humans are now numerous. The results are simply staggering. Specifically, resveratrol has been shown to help prevent common illnesses and ailments, and has even been linked to warding off serious conditions such as cancer and heart disease. In addition to supporting the immune system, resveratrol has been shown to have a positive impact on the metabolism as well, helping the body digest faster and more efficiently.
Quercetin is a substance found in apples, red onions, oranges, grapefruits and red grape skins. It is believed to be another powerful antioxidant with anti-inflammatory, anti-bacterial, anti-viral and anti-histamine properties.
Stuart Cracraft, moderator of the Resveratrol Users Group, hopes the compound will give him a few more healthy
Eight years ago, Stuart Cracraft became a father. As his twin daughters grow up, he worries that his body and mind might not be able to keep up.
After witnessing his mother's death following a devastating eight-year illness, Cracraft, an IT worker, decided he wanted to try and spare his own daughters such an experience with him. So he changed his diet, cutting back on sugars and adding plenty of egg protein and fish. He started drinking tea and taking fish-oil supplements and multivitamins. It wasn't exactly a radical regimen, but he was willing to go further.
After three years researching a compound found in red wine called resveratrol, which has been shown to extend life and reduce disease in lab animals, he began taking 50 milligrams a day. "It seems it's more powerful than all the antioxidants put together," Cracraft says. "You get all that in one pill, and it's too good to pass up."
Hope for a fountain of youth may spring eternal, but these days it is surprisingly active among the ranks of highly educated and even scientifically trained professionals -- despite what experts say is a lack of compelling clinical evidence for any particular treatment.
Inventor and artificial intelligence theorist Ray Kurzweil has promoted life extension for years, and revisited the theme in his latest books, Fantastic Voyage: Live Long Enough to Live Forever and The Singularity Is Near, When Humans Transcend Biology. PayPal co-founder Peter Thiel recently donated $3.5 million to the Methuselah Foundation, the longevity research organization created by Aubrey de Grey, a computer programmer who claims that humans could live for 1,000 years.
Another resveratrol devotee and computer programmer who asked to remain anonymous has gone even further and embraced calorie restriction -- another method unproven in humans that's associated with radical life extension.
"Engineers accept that anyone who understands a system also has the power to change it," he says. "A real engineer refuses to accept bugs in any code, whether his own, his tools, his operating system or his own body."
Resveratrol, which has protected lab animals from heart disease, cancer, Alzheimer's and Parkinson's diseases, seized the public imagination in November 2006 when two prominent studies showed that mice taking the compound lived longer and ran farther than mice not taking it. Still, scientists say it's far from certain that it will extend human life.
Waiting for the compound to be tested in humans, however, is not an option at his age, Cracraft says. He expects it will extend human life by about 30 percent, so waiting 10 years could cost him three. Altogether, Cracraft says, "I could get 10 more years."
Dominique Vocat, a 32-year-old IT worker in Basel, Switzerland, is even more optimistic. He figures resveratrol will add a few extra years to his life -- and in the meantime, scientists will develop serious life extension technologies. Then he might live to 200.
"Computer geeks think technology can fix anything," says Steven Austad, a cellular biologist and longevity researcher at the University of Texas. "People in the research community tend to think of mice as small little furry humans with long tails, but they're not. We don't know what it will do."
Resveratrol is the compound responsible for what is commonly referred to as the French Paradox. This paradox has been noted on many news documentary programs and has increased the selling value of red wine and grape juice.
It involves the strange relationship between the amount of wine commonly consumed in French culture, and the evidence of a lowered risk of heart disease among the French.
Resveratrol is commonly found in red grapes and wine, as well as pine trees and peanuts. It has been used in Asian cultures for many years for the purposes of treating heart problems, as well as disorders of the liver.
The many benefits of resveratrol include antioxidant properties, which means it is capable of ridding the body of dangerous and harmful free radicals that might eventually lead to the development of cancer.
The compound is also thought to be capable of actually killing cancer cells that have already developed. Additionally, resveratrol is beneficial in protecting the central nervous system, regulating hormones and acting as a blood thinning agent.
Further benefits of resveratrol include reducing the risk of Alzheimers disease, especially when combined with Vitamin E and Vitamin C. Early studies indicate that resveratrol may also have uses in therapeutic treatment of post stroke care, as well as injury and trauma related to the spine and central nervous system.
Resveratrol studies also indicate that resveratrol may even play a critical role in expanding life spans.
Finally, it is believed that resveratrol may be crucial in preventing certain kinds of cancer, especially breast cancer, and reducing the risk of cancers spreading into bones.
Since this compound works as a blood thinning agent, individuals who are already taking anti-coagulants, should be very cautious about introducing supplemental forms of this nutrient into their daily regimen, without first speaking with their physician.
While it is always best to obtain nutrients and vitamins from natural food sources, when there are severe deficiencies, or it is not possible to obtain vitamins from dietary means, supplements can be a great way to introduce these much needed nutrients into the body.
Resveratrol has been shown to be a very powerful substance. In a US study it has been shown to extend the life span of yeast cells by up to 80 per cent.However, studies have not been done on humans yet. They would need to conduct tests on humans using this substance to see if these types of similar benefits apply.
Another thing to note is, because there are negative side effects of drinking alcohol that are detrimental to your health, we do not believe any of these promising studies gives one a reason to begin drinking red wine daily.
Taking resveratrol in supplement form in our opinion seems to be a much more preferable and wise choice to get the required benefits without the damaging effects of alcohol on your health.
Tips For Choosing A Resveratrol Supplement
1. Purchase your supplements from pharmaceutical GMP compliant manufacturers. This is especially important for consumers because supplements are now largely unregulated in the US and the UK meaning customers of health supplements only have a 1 in 5 chance of buying a supplement that actually has the ingredients contained stated on the label.
What's more worrying is the fact many of these supplements in the health industry have been found to contain harmful contaminants. We thought health supplements were designed to maintain and promote health. Unfortunately, they can actually impair your health.
2. Before you buy resveratrol of any kind, be sure your resveratrol supplement does not contain any fillers or additives (examples include: sugar, starch, gluten, silica (sand!)) or any artificial colours or flavours.
Anti aging. In studies conducted at Harvard University, mice getting supplemental resveratrol had higher activity of the SIRT1 gene. They also had lower levels of insulin-like growth factor-l, considered a risk factor for cancer. The mice also lived about 15 percent longer (the equivalent of 11 human years) compared with mice that were not fed resveratrol. Even with advancing age, the mice maintained physical activity and coordination more like that of younger mice. The benefits were all the more striking because the mice were red the equivalent of a junk food diet.
Diabetes. The Harvard University researchers also found that mice eating a high-calorie diet and taking resveratrol did not develop diabetes; however, animals not getting the antioxidant did develop the disease. In a small study of men with type 2 diabetes, resveratrol supplements reduced fasting blood sugar levels and improved insulin function. Diabetes is known to accelerate the aging process. A second study using resveratrol to treat people with diabetes is under way.
Heart Disease. Animal studies suggest that resveratrol may lower the risk of heart disease. Resveratrol has anti-inflammatory properties--important because heart disease is now considered an inflammatory disease of the arteries. Resveratrol may also prevent oxidation of cholesterol, regarded as an early step in the development of heart disease. Additionally, resveratrol has a mild blood-thinning effect, which would reduce the risk of blood clots.
Cancer. Growing evidence suggests that resveratrol might have a role in cancer prevention. Resveratrol seems to prevent different stages of cancer growth and reduce cell division and metastasis, according to an article in Cell Cycle. Seven studies using resveratrol as an adjunct in the treatment of cancer in people are under way, but the results won't be known for several years.
There are millions of processes that are occurring in a human body at all times which require oxygen. Unfortunately, that same life giving oxygen can create harmful side effects, or oxidant substances, which cause cell damage and lead to chronic disease. Oxidants are also introduced through external sources such as exposure to the sun or pollution. Other mediums include stress, as well as things that people put into their bodies, such as alcoholic beverages, unhealthy foods, and air pollution. Resveratrol has been demonstrated to be a potent anti-oxidant
In much the same way as oxidation creates rust, causing a breakdown on the surface of inanimate objects, oxidation inside the body causes a breakdown of cells. Free radicals produced by this breakdown attack healthy cells, usually DNA as well as proteins and fats. This chain of events weakens immunological functions as well as speeding up the aging process, and is also linked to several diseases such as cataracts, various forms of cancer, and heart disease.
The antioxidant in resveratrol, reduce the effect of dangerous oxidants by binding together with these harmful molecules, decreasing their destructive power. Antioxidants can also help repair damage already sustained by cells. It is also believed to have an anti-clotting effect that prevents the formation of thrombi or blood clots in the blood vessels. The formation of thrombi that block small blood vessels is the cause of heart attacks and strokes. Resveratrol capsules have also been demonstrated to promote the formation of new dendrites in the brain.
Resveratrol, the life-extending nutrition, is naturally occurring in dark grape skins and seeds, peanuts, Japanese Knotweed and Chocolate. Resveratrol is produced by plants to help fend off attack from molds and other pathogens. Experiments on fruit flies, worms and fish confirmed the natural Resveratrol's ability is not only to extend lifespan, but to delay the debilitating effects of aging.
Drinking red wine may help fight inflammation in the body, according to research at the University of Glasgow.
Resveratrol, an antioxidant found in red wine, protected mice when they were exposed to a strong inflammatory agent, scientists at the university concluded.
Mice that were not pretreated with resveratrol developed a serious reaction similar to the inflammatory disorder sepsis.Resveratrol blocks two major proteins in the body that trigger inflammation, the study found.
Strong acute inflammatory diseases such as sepsis are very difficult to treat and many die every day due to lack of treatment, said Alirio Melendez of the University of Glasgow.
Moreover, many survivors of sepsis develop a very low quality of life due to the damage that inflammation causes to several internal organs, he said.
The ultimate goal of our study was to identify a potential novel therapy to help in the treatment of strong acute inflammatory diseases.
Resveratrol has been associated widely with health benefits ranging from anti-aging to boosting anti-viral treatments. Previous studies have found that resveratrol can help prevent blood clots and combat cancer. The antioxidant is found in the skin of grapes, but it occurs in greater quantities in red rather than white wine.
The study was outlined in the Federation of the American Societies for Experimental Biologys FASEB Journal.
The therapeutic potential of red wine has been bottled up for thousands of years, said Gerald Weissmann, the journals editor in chief.
Now that scientists have uncorked its secrets, they find that studies of how resveratrol works can lead to new treatments for life-threatening inflammation.
The most efficient way of administering resveratrol in humans appears to be buccal delivery, that is without swallowing, by direct absorption through the inside of the mouth. For example, with resveratrol lozenges. When one mg of resveratrol in 50 mL solution was retained in the mouth for one min before swallowing, 37 ng/ml of free resveratrol were measured in plasma two minutes later. This level of unchanged resveratrol in blood can only be achieved with 250 mg of resveratrol taken in a pill form. So perhaps if you take resveratrol in liquid form you can improve the absorption rate by swilling it around your mouth before swallowing.
About 70% of the resveratrol dose given orally as a pill is absorbed; nevertheless, oral bioavailability of resveratrol is low because it is rapidly metabolised in intestines and liver into conjugated forms: glucuronate and sulfonate. Only trace amounts (below 5 ng/mL) of unchanged resveratrol could be detected in the blood after 25 mg oral dose.
In humans and rats, less than 5% of the oral dose is being observed as free resveratrol in blood plasma. The most abundant resveratrol metabolites in humans, rats, and mice are trans-resveratrol-3-O-glucuronide and trans-resveratrol-3-sulfate. Walle suggests sulfate conjugates are the primary source of activity, and Boocock et al. also emphasized the need for further study of the effects of the metabolites, including the possibility of deconjugation to free resveratrol inside cells. Goldberd, who studied the pharmacokinetics of resveratrol, catechin and quercetin in humans, concluded "it seems that the potential health benefits of these compounds based upon the in vitro activities of the unconjugated compounds are unrealistic and have been greatly exaggerated. Indeed, the profusion of papers describing such activities can legitimately be described as irrelevant and misleading. Henceforth, investigations of this nature should focus upon the potential health benefits of their glucuronide and sulfate conjugates." has been disproved by experimental data. For example, after five men took 600 mL of red wine with the resveratrol content of 3.2 mg/L (total dose about 2 mg) before breakfast, unchanged resveratrol was detected in the blood of only two of them, and only in trace amounts (below 2.5 ng/mL). Resveratrol levels appeared to be slightly higher if red wine (600 mL of red wine containing 0.6 mg/mL resveratrol; total dose about 0.5 mg) was taken with meal: trace amounts (16 ng/mL) were found in four out of ten subjects.
When it comes to Resveratrol, you really couldnt name a more famous discovery within this modern day and age. Resveratrol has been talked about everywhere, from the newspapers to the Internet. Resveratrol has stepped into the door with a reputation that remains very solid.
With that said, there have been many research studies on Resveratrol, and understanding how the dosage works when it comes to Resveratrol will alleviate the concerns of many people who are looking at adding Resveratrol into their lifestyle.
Although, when it comes to Resveratrol dosage, the results can differentiate depending upon the person.
Thats right. The dosage that works great for one person can be different on another person who tried that exact same dosage that worked great for the other person. The statistics of Resveratrol dosages are usually done by testing the level in your blood or through a urinalysis where the Resveratrol level is found as well.
The lowest dosage I have seen results for is 40MG using extract from Japanese Knotweed in a study during 2010, however earlier studies considered anything between 100-500MG as low and anything over 1500MG as High, which is a huge range. There are also different concentrations and blends of resveratrol to be considered as well.
How much a supplement should take is only one of many factors involved in this. When it comes down to it, nobody knows what is right for you besides your doctor. Therefore, before taking Resveratrol, you should seek medical advice from your regular physician.
Keep in mind, your doctor is the only one that can help you effectively when it comes to choosing your Resveratrol dosage level. It is highly important that you let your doctor know about any particular medications that you think you could be allergic to, this way youre not mixing Resveratrol with anything that could cause a harmful reaction.
There are many other things that need to be looked at closely before jumping onto the Resveratrol bus. However, the best Resveratrol supplements will have information that could answer any questions that you may have about taking a Resveratrol supplement. Hopefully, this article helped you understand Resveratrol a little bit more. After all, it is a great discovery that has changed the live of many people from around the world.
As far back as 2008 resveratrol was been studied to find out if it could be used to treat cancer, at that time
the researchers, from the Rogan lab at the University of Nebraska, were studying a chemical purified from red wine, called resveratrol. By looking at its effect on cancer cells in a laboratory, they found that resveratrol could prevent a type of DNA damage that has been implicated in breast cancer.
This damage involves oestrogen, a hormone which can increase the risk of breast cancer if people are exposed to raised levels over time. Our bodies can sometimes convert oestrogen into a form that can actually react with DNA, to create bulky extensions called adducts. There is some evidence that these adducts are a sign of the development of breast cancer, and can actually cause cancer in animals.
The researchers found that resveratrol blocks the process that creates these adducts. It turns on an enzyme called quinone reductase that switches the reactive version of oestrogen back into its inactive form. Even better, it only took low concentrations of resveratrol to do this.
A new study in 2010 reported that resveratrol can prevent silencing of the BRCA1 gene, a gene that protects against breast cancer through its role in repairing DNA damage, but as yet resveratrol has not become a recognised cancer treatment.
Nobody wishes to die early, and generally we look to healthy alternatives to culturally defined eating patterns and health care to extend life and live longer. The benefits of drinking wine have been touted for a while and are thought, by some, to be the reason why the French can get away with eating a high fat diet while enjoying a low rate of coronary disease. A few years ago, a study by French research team also found that men who regularly drank at least two glasses of wine daily were 50 percent less likely than non-drinkers to suffer a second heart attack.
Previous studies with yeast, a small species of worm, and fruit flies have shown that resveratrol a polyphenol antioxidant found in grapes, especially red grapes, and particularly pinot noir grapes which are grown in northern latitudes and used in wines coming from New York, Washington, and Oregon is a life-extending compound. In a study from Italy, resveratrol has been used to increase the life span of a short-lived breed of tropical fish by more than 50%. Not only did fish given resveratrol in their food live longer than the control group, they stayed livelier as they aged and displayed better memory in stimulus/response tests. And the neurons in their brains didnt decay as quickly when they died and were dissected.
Resveratrol, an organic compound contained in the skins of grapes that protects them from disease, is extracted from grapes by the wine making process. The wine becomes a preservative for the resveratrol and prevents its oxidation. Thats why drinking grape juice or eating raisins doesnt have the same effect; the resveratrol has neither been extracted nor preserved. Its also been shown that resveratrol in food supplements oxidizes upon exposure to air and loses its effectiveness. Red wine may truly be a wondrous drug!
Other studies have shown that wine, especially red wine, can help prevent colds, increase the levels of HDL (good) cholesterol, lower the risk of Alzheimers, reduce the size and number of fat cells in the body, reduce the risk of prostate cancer, and has anti-inflammatory properties to boot.
Resveratrol has been dubbed as the most potent antioxidant of the 21st century and has received much commend since studies released in 2006 indicated its health benefits. Many have queried whether it can repress cancerous cells and resveratrol and prostrate cancer cure have been linked many times.
If you are male then this news is excellent news as prostate problems is one of the most common cancers in men similar to breast cancer in women and the linkage between resveratrol and prostate trouble is really exciting indeed.
Resveratrol can be found in many dark skinned fruits such as raspberries, cranberries, blueberries,red grapes plus Japanese knot weed, peanuts and cacao.
The results of contemporary testing have been encouraging so it would seem prudent for men in the over fifty age bracket, the likeliest to suffer because of this form of cancer, to consider taking a resveratrol supplement on a regular basis. In fact as resveratrol has plenty of other health benefits such as fighting diabetes, reducing the aging process, helping to reduce wrinkles and age spots and boosting energy itd be a good supplement to take simply for improving over all health whatever your age and gender.
Recent research in Australia where scientists followed 1,216 women over the age of 70 for a period of nine and a half years, showed that those who ate chocolate at least once a week were 30% less likely to be hospitalised or die from heart disease and 60% less likely to be hospitalised or die from heart failure, than those that ate less than one serving a week. A serving was equal to the amount of Cocoa used in a cup of cocoa.
They found that the women who ate chocolate daily and those who ate it weekly experienced comparable heart benefits. more research is needed to explain the results.
Cocoa, the principal ingredient of chocolate, is a rich source of flavonoids which includes resveratrol. Higher flavonoid intakes are associated with a lower risk of cardiovascular disease, and flavonoid-rich cocoa and chocolate can reduce blood pressure and improve endothelial function. So resveratrol might be a possible explanation.
There is information to demonstrate that Resveratrol can be effective at improving heart function and reduce the risks of heart disease and heart attacks.
There is also compelling evidence to suggest that resveratrol does benefit the circulation of blood around the body and helps prevent blood clots and blockages of the arteries.
Extending life expectancy?
There have been quite a number of experiments carried out on several animal species which have given encouraging results and help improve the their is a likelihood that Resveratrol may possibly extend life in humans.
Most initial research carried out has been on fish and these results have been very encouraging but similar tests on mice have not been so exciting. However more testing is ongoing and many scientists are excited that Resveratrol may hold some hope of prolonging life and slowing down the aging process.
Increased energy levels?
Resveratrol obtained most often from Japanese Knotweed (a grass found in Japan) is stated by many men and women to have given them an extra energy boost.
It is a possibility these claims derived from a naturally occurring plant with no known major side effects that has lead to most of the excitement associated with Resveratrol.
It has been shown that with out doubt Resveratrol is exciting anti oxidant and this helps get rid of the free radicals which are produced as part of the usual aging process and also by pollutants in the air. It is this that is believed to help us feel more energised and may also perform some part in slowing down the aging process.
No one would choose to grow old and we are looking for for the fountain of eternal youth but does it exist? Its obviously impossible to stop the aging process and stay a young man or woman for ever but many scientists believe that Resveratrol could help slow down the aging process.
This may be on the whole due to its action in eliminating free radicals but the real reason is still shrouded in mystery and many people are now taking Resveratrol knowing that even though it may not hold the secret of everlasting youth they have noticed some significant health benefits.
Resveratrol, a compound found in red wine, is the only compound that has lengthened the life of every organism its been given to: yeast, worms, flies, and mice. As far back as 1996 David Sinclair of Harvard University showed that this resveratrol can also combat the ill health effects of a high-fat ("McDonald's") diet in mammals. Mice that were given a high-fat diet as well as Resveratrol lived as long as mice that were fed a healthy balanced diet. Even more interesting is the fact that the mice were not administered Resveratrol until they were 1 year old (the equivalent of a 40-year-old human), which means that the compound is effective at later stages in life presumably after the effects of an unhealthy diet have taken a toll. According to Dr. Sinclair, the compound "improves the chances of survival by 30% on any given day."
Post-mortem examination of these "McDonald's" mice has revealed huge differences between those given Resveratrol and those who didn't receive it. First, the McDonald's mice who received none of the compound had large fatty livers (steotosis) while the ones that received Resveratrol did not. They were indistinguishable from normal livers. In addition, the cardiovascular system of the McDonald's mice where clogged and marked by atherosclerosis, while the mice given Resveratrol looked normal and healthy. Humans exhibit these same symptoms when they have a high-fat diet, so this is very promising that his research may have direct applicability.
The hypothesis is that Resveratrol activates gene pathways which are related to longevity, specifically an enzyme called SIRT1. Mice that lack SIRT1 (knockouts) have a shorter lifespan and more developmental defects compared to wild type mice. It has been postulated that SIRT1 proteins likely promote survival and stress resistance in times of adversity, and that the compound Resveratrol activates SIRT1 protein production.
Does this explain the so-called "French Paradox," where regular consumption of red wine is credited with reducing the incidence of cardiovascular disease among a people whose diet includes large amounts of saturated fats. While moderate consumption of alcoholic beverages seems to be beneficial to overall health, consumption of red wine confers the most significant benefits to cardiovascular health.
Resveratrol has been in the media a great deal over the past few years because it is a powerful antioxidant with unique health benefits we have only now discovered. Resveratrol is most naturally concentrated within red grape skins and this is why red wine has become so popular and marketed today. Red wine, offers a percentage of Resveratrol within its ingredients and consumers are taking advantage of Resveratrol this way.
You may ask is drinking grape juice can offer the same benefits with out the alcohol. This is a difficult question to answer because there are many angles to analyse. While studies say drinking 1,000 glasses of red wine a day is just enough to reap the benefits of Resveratrol, alcohol abuse can easily be created through this method of utilization. Secondly, by consuming grape juice on a regular basis it will begin to act as an antibiotic for your body. Grape juice can then combat all the free radicals within your body meant to harm your long term health.
Not everyone likes to drink wine or consume alcohol at all and because of this, many people are turning towards grape juice for their own daily diets as well as their childrens. Although fresh grape juice has higher levels of Resveratrol then red wine, you still need to drink tens of glasses of grape juice each day to gain the benefits of Resveratrol. The main problem with this is that grape juice usually contains high levels of sugar, which can in turn lead to different diseases such as obesity. This is why Resveratrol supplements are being created so we can fully take advantage of these natural health benefits.
If you choose to start reaping the benefits of Resveratrol today you may find that within 10 years there are hundreds more natural health benefits associated with Resveratrol. While studies are still underway, Resveratrol can be taken advantage of today. You do not have to wait for the approval of anyone to take advantage of what nature has provided for us. Get ahead of the masses when it comes to your health and take control of your aging process. Age gracefully and with reduced risk of illness and debilitating diseases with Resveratrol.
Resveratrol is actually a substance which had been first found in plants. It is created by the plant every time a plant comes under attack external aids that can affect its existence. Including invasion from bacteria and additionally from fungi that could stunt a plants growth or make it die. Each time a person is looking for a method to treat their cancer they will find good results with using chemical medications. On the other hand, many medications men and women decide to try to treat or avoid cancer can in fact become addictive that will have deadly unwanted side effects. Therefore, large numbers of people are trying to find all-natural treatment options to aid in cancer protection.
Resveratrol restricts and reduces cancer by subsequent actions:
Being an antioxidant However is not precisely classified as antioxidant, but resveratrol demonstrates a lot more powerful antioxidant-like feature that fights free radicals in the body. The toxins are the reason for many mutation and cell deterioration which could graduate to cancer; at the time you eradicate the toxins, you terminate one root cause of cancer.
As apoptosis inducer When theres something amiss during cell division or even a mutant cell is formulated, the cells are hot wired to kill itself (apoptosis, thats a type of suicide if you may) simply to stop it from developing into cancer. But in some instances, apoptosis wont occur and also formation of cancer is pending. Resveratrol helps stimulate apoptosis.
As cancer cells mitochondria inhibitor Resveratrol acts on mitochondria in cancer cells that obstruct its correct functioning, thus limiting the needed energy for cancer cells to multiply. This course of action also plays a role in the oncoming of apoptosis.
As chemo- and radiotherapy help It has additionally been observed that resveratrol can aid one other treatments of cancer for example chemo- and radiotherapy by safeguarding the healthy cells in opposition to their unwanted effects.
Resveratrol is often taken by those who are in various stages of cancer. Additionally, it could be taken by those who do not possess cancer, but desire to prevent the oncoming of various varieties of cancer. These resveratrol supplements are safe to take and if taken on a daily basis have been proven effective in decreasing the effect connected with cancer. These supplements are available in pill or liquid form that can be taken daily.
Resveratrol truly is known as a miracle substance, it can be taken to reduce high blood pressure and to extend life.
Resveratrol is a natural antioxidant compound found in some plants, fruit, seeds, grapes, and grape-derived products such as red wine. Resveratrol is a polyphenol that has been found to potentially improve health and well-being in laboratory studies from around the globe.
In addition, emerging laboratory research has found that resveratrol fights cellular aging. These studies also found that resveratrol activates genetic regulators of cellular longevity pathways, which may have positive effects on DNA, cellular health, and metabolism
One source of natural resveratrol is Vivix® Cellular Anti-Aging tonic is a patent-pending, powerful, and exclusive polyphenol blend with ingredients shown in laboratory research to positively impact the four key mechanisms of cellular aging:
DNA damage
Genetic regulators
Declining cellular energy production in Vitalizer, immune-system-supporting phytonutrients
Accumulation of advanced glycation end-product (AGE) proteins
In a major breakthrough, a recent clinical study genetic regulator of longevity called Nrf2 and helped turn down cellular aging. This was a randomised, placebo-controlled clinical study (i.e., the most rigorous kind). It was also an independent study performed not by Shaklee but by scientists at State University New York at Buffalo. The manuscript has been submitted to a scientific journal and is currently under review for publication.
28. Resveratrol According to research compled at the Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX 78712 by messrs Delia M. Brownson, Nicolas G. Azios, Brie K. Fuqua, Su F. Dharmawardhane, and Tom J. Mabry
Flavonoids, such as daidzein and genistein, present in dietary plants like soybean, have unique chemical properties with biological activity relevant to cancer. Many flavonoids and polyphenols, including resveratrol in red wine and epigallocatechin gallate in green tea, are known antioxidants. Some of these compounds have estrogenic (and antiestrogenic) activity and are commonly referred to as phytoestrogens. A yeast-based estrogen receptor (ER) reporter assay has been used to measure the ability of flavonoids to bind to ER and activate estrogen responsive genes. Recently, estrogenic compounds were also shown to trigger rapid, nongenomic effects. The molecular mechanisms, however, have not been completely detailed and little information exists regarding their relevance to cancer progression. As a preliminary step toward elucidating rapid phytoestrogen action on breast cancer cells, we investigated the effect of 17-ß estradiol (E2), genistein, daidzein and resveratrol on the activation status of signaling proteins that regulate cell survival and invasion, the cell properties underlying breast cancer progression. The effect of these estrogenic compounds on the activation, via phosphorylation, of Akt/protein kinase B (Akt) and focal adhesion kinase (FAK) were analyzed in ER-positive and -negative human breast cancer cell lines. E2, genistein and daidzein increased whereas resveratrol decreased both Akt and FAK phosphorylation in nonmetastatic ER-positive T47D cells. In metastatic ER-negative MDA-MB-231 cells, all estrogenic compounds tested increased Akt and FAK phosphorylation. The inhibitory action of resveratrol on cell survival and proliferation is ER dependent. Therefore, all estrogenic compounds tested, including resveratrol, may exert supplementary ER-independent nongenomic effects on cell survival and migration in breast cancer cells.
As with most research it will require comprehensive studies and controlled trials to conclusivily prove effects of long term consumtion of resveratrol.
We all want to live long, vibrant and healthy lives. At one time intervention in the aging process was regarded as science fiction however it is today within our reach due to breakthroughs in nutritional science.
Resveratrol, a substance that is abundant in red wine, and continues to make headlines for its anti-aging potential and its well-documented antioxidant and cardiovascular benefits. Resveratrol has been shown for instance from research at Harvard Medical School to increase the lifespan of yeast cells a finding that may help explain the life extending effects of the Mediterranean diet.
Resveratrol in the latest news
Researchers at Harvard Medical School made headlines when they identified
a plant molecule they believe may hold the key to slowing the human aging process. The compound, Resveratrol, is produced by grapevines and other plants in response to environmental stress.
The groundbreaking study, reported in the journal Nature, showed that Resveratrol
mimics the life-extending effects of calorie restriction and increases the lifespan of yeast cells by up to 80%. Resveratrol was found to activate certain enzymes that influence the genes that regulate aging. This research may help explain the long-established association between moderate red wine consumption and cardiovascular health and longevity.
Wide-Ranging Anti-Aging Benefits
Previous research has documented resveratrols many health benefits:
Resveratrol is a phytoestrogen, which may protect breast, prostate, and endometrial tissue, according to animal and in vitro research.
Resveratrol was found to support healthy mammary and skin tissue in mice by suppressing damaging free radicals.
Resveratrol may support healthy circulation, according to human and animal studies.
Resveratrol has been shown to reduce LDL (bad cholesterol) oxidation and to promote healthy HDL (good cholesterol) levels.
Resveratrol was found to inhibit the Cox-1 and Cox-2 enzymes, which are involved with cellular irritation and cellular growth and regeneration, according to in vitro studies. Recent research focuses on its role in suppressing Cox-2 via the action of NFkappa B, an important DNA regulating factor.
Non-Alcoholic Sources
Most publicity about resveratrol focuses on its presence in grape skins and red wine. However, this beneficial compound is found in other plants. Japanese Knotweed also known as Hu Zhang root, is a celebrated traditional Chinese herb. Peanuts and chocolate are some other sources.
Resveratrol is the compound responsible for what is commonly referred to as the French Paradox. This paradox has been noted on many news documentary programs and has increased the selling value of red wine and grape juice.
It involves the strange relationship between bad diet of French people and the amount of wine they drink which provides the evidence of a lowered risk of heart disease among the French.
Resveratrol is commonly found in red grapes and wine, as well as pine trees, peanuts and Knotweed. It has been used in Asian cultures for many years for the purposes of treating heart problems, as well as disorders of the liver.
The many benefits of resveratrol include antioxidant properties, which means it is capable of ridding the body of dangerous and harmful free radicals that might eventually lead to the development of cancer.
The compound is also thought to be capable of actually killing cancer cells that have already developed. Additionally, resveratrol is beneficial in protecting the central nervous system, regulating hormones and acting as a blood thinning agent.
Further benefits of resveratrol include reducing the risk of Alzheimers disease, especially when combined with Vitamin E and Vitamin C. Early studies indicate that resveratrol may also have uses in therapeutic treatment of post stroke care, as well as injury and trauma related to the spine and central nervous system.
Studies also indicate that resveratrol may even play a critical role in extending life spans.
Finally, it is believed that resveratrol may be crucial in preventing certain kinds of cancer, especially breast cancer, and reducing the risk of cancers spreading into bones.
Since this compound works as a blood thinning agent, individuals who are already taking anti-coagulants, should be very cautious about introducing supplemental forms of this nutrient into their daily regimen, without first speaking with their physician.
Resveratrol is regarded by some to be the elixir of life, as one drinks from this golden challenge one need to be aware of possible side effects which could occur and take sensible action.
Although Resveratrol is not known to be toxic or cause adverse effects in humans, but there have been only a few controlled clinical trials to date. A recent trial that evaluated the safety of oral resveratrol in ten subjects found a single dose up to 5 grams resulted in no serious adverse effects (103). In rats, daily oral administration of trans-resveratrol at doses up to 300 mg/kg of body weight for four weeks resulted in no apparent adverse effects (104, 105).
Pregnant and Nursing Mothers
There is no recommended safety level relating to the consumption of resveratrol supplements during pregnancy and lactation. Neither is there a safe level of alcohol consumption recommended at any stage of pregnancy however pregnant women should avoid consuming wine as a source of resveratrol at this time and manufactures suggest suspending taking resveratrol at this time.
Estrogen-sensitive Cancers
Until more is known about the estrogenic activity of resveratrol in humans, women with a history of estrogen-sensitive cancers, such as breast, ovarian, and uterine cancers, should avoid resveratrol supplements (see Estrogenic and Anti-estrogenic Activities above).
Anticoagulant and Antiplatelet Drugs
Theoretically, high intakes of resveratrol say from supplements could increase the risk of bleeding when taken with anticoagulant drugs, such as warfarin (Coumadin); antiplatelet drugs, such as clopidogrel (Plavix) and dipyridamole (Persantine); and non-steroidal anti-inflammatory drugs (NSAIDs), including aspirin, ibuprofen, and others. So users are advised to watch for this possible side affect.
Hardly a day passes without someone on the media mentioning resveratrol, many people though still do not understand what this antioxidant can have a great effect on human life.
Although resveratrol has existed in plants which have been used for generation for treating ailments it was not until it was "discovered" by a pre-WWII Japanese scientist who isolated a resin from Veratrum species plants. He had little time expand his discovery due to the war and so it was left to a doctor Serge Renaud to identify the compound we know of today as resveratrol in a bottle of French red wine.
This marked the beginning of the French pardox where he noted that although the local people consumed a fatty diet they also had a lower incidence of heart disease and the only thing that set them apart from other Western people apart from the Italians was they drunk red wine which contained resveratrol
Many studies have been carried out on the powerful anti oxidant mostly in labororatry and rodents and the like together with a few on humans. Results show that resveratrol does make the skin look and feel younger removing wringles nad turning back the clock of time. The jury is still out as to if it will physically extend a persons age as it has does in experiments on animals
Many people believe that resveratrol only naturally occurs in Red wine, which is far from the truth. Well, red wine is famous for its contributions in keeping ones heart healthy, and Resveratrol is understood to have multi-modalities of heart-tending actions.
Take for example The French Paradox? If you havent heard of it, well, it is a generally used expression to mean the direct organisation between alcohol consumption and fatty diets. You see, most French people commonly smoke and their usual diets contain high levels of saturated fat. However they are also lovers of red wine, in fact part of their daily drill, and red wine is understood to protect our bodies from cardiovascular illnesses. The secret is in their consumption of red wine which has resveratrol. Resveratrol is a phytoalexin produced by some plants to ward off pathogens like bacteria or fungi. Latest advances in technology allow Resveratrol to be synthesized chemically.
Since red wine already contains high levels of Resveratrol, what makes this cardiovascular illness prevention all the more fast is the presence of flavonoids, working hand in hand with Resveratrol.
Red wine is one of the richest sources of Resveratrol, more so than regular grape juice because of the fermentation process it undergoes. Grape skin contains the highest natural concentration of Resveratrol. Other sources of Resveratrol include peanuts, eucalyptus leaves and Eastern Knotweed with Japanese Knotweed being the primary source for supplement extracts.
Aside from that, resveratrol also helps keep cancer cells and phytoestrogen from junk food in check. In relation to this naturally is the cardiovascular system.
The heart system for the transport of nutrient elements, gases, hormones, blood cells, nitrogen waste products and so on, from and to cells in the body to keep it in homeostasis. Coronary disease in particular is the premiere cause of death in the USA, UK, and Canada and is quickly becoming a pandemic because of the nature of our daily diet consumption. Statistics indicate that coronary disease claims the life of one individual each 34 seconds in the USA alone.
Resveratrol also serves as a blood thinning agent, minimizing system damaging clots that form because of impurities in blood. This in turn helps in avoiding damage to the arteries that are commonly found in occurrence when blood clots break free and circulate.
There are many people who prefer to avoid alcohol and its side effects, and they can take concentrated supplements in liquid or pill form, as the natural resveratrol benefits only occur after a long period of time or if consumption is increased.
Resveratrol was first found in 1940 in the roots of a plant called Veratrum
grandiflorum. Later on, in 1976, resveratrol was discovered in grapes, and in
1992, resveratrol was also identified in wine, peanuts, Japanese Knotweed, yucca, and chocolate. Resveratrol is a polyphenol compound that may have health benefits on various chronic diseases. It exhibits a wide range of biological effects, including antiplatelet, anti-
inflammatory, anticancer, antimutagenic and anti fungal properties. This
compound is also believed responsible for some of the beneficial effects of
moderate red wine drinking on the cardiovascular system. One litre of red wine
contains 1.5-3 mg of resveratrol. Resveratrol also exists in grapes. Resveratrol
supplements are popular in the US and other countries.
Resveratrol is considered as a dietary phytoalexin. Phyto comes from the word
phyton which means a plant, while alexin means to defend. Phytoalexin means
plant antibiotic produced by a plant in response to the entry of a disease-
producing substance. [8]
Resveratrol Research
Arthritis
Resveratrol, one of the key ingredients in Yucca, is believed to contribute a
part of the health benefits of Yucca. Yucca schidigera Roezl. (Agavaceae) has
been traditionally used to treat a variety of diseases including arthritis and
rheumatism. Researchers demonstrated that resveratrol inhibited the
expression of VEGF, MMP-3, MMP-9 and COX-2 in human
articularchondrocytes stimulated with the pro-inflammatory cytokine IL- 1beta.
Furthermore, resveratrol suppressed apoptosis and
inflammatory signaling through its actions on the NF-kappaB pathway in
human chondrocytes. Resveratrol possessed COX-1 inhibition, COX-2
inhibitory potential and an LTB 4 formation inhibitory activity in an in vitro study.
Cytokine macrophage migration inhibitory factor as a crucial factor in the
pathogenesis of rheumatoid arthritis while resveratrol was a potent inhibitor as
the antipyretic-analgeticdrug acetaminophen.
Intra-articular injections of resveratrol on cartilage and synovium could
significantly decreased cartilage destruction in an experimental rabbit
inflammatory arthritic model.
Cancer
As early as 1997, researchers have proposed to use resveratrol as a cancer-
preventive agent. Resveratrol was shown to have anti-cancer activities in
assays representing three major stages of carcinogenesis.
Resveratrol has been shown to inhibit cancer initiation and promotion. It
acts as a selective estrogen receptor modulator (SERM) and regulates
proteins involved in DNA synthesis and cell cycle. Resveratrol also affects the
activity of transcriptional factors involved in proliferation and stress responses,
such as NF-kB, AP1 and Egr1.
Researchers from researchers at Cook County Hospital found that gastric
adenocarcinoma cells respond to resveratrol treatment with suppression of
DNA synthesis, activation of nitric oxide synthase, induction of apoptosis and
inhibition of total PKC and PKC alpha activity.
Resveratrol adds to the growth inhibitory/anticancer activity of cisplatin and
doxorubicin in vitro and protects against doxorubicin-induced cardiac toxicity
both in vitro and in mice. Researchers found that high-doses of resveratrol
triggered apoptosis in five out of six uterine cancer cell lines. Resveratrol
exhibited a variety of molecular events in etoposide-based combination
therapy in HT-29 colon cancer cells. Resveratrol also induced growth inhibition
in T47D human breast cancer cells. Researchers from China Medical
University, Taiwan, found resveratrol significantly inhibited growth factor
heregulin-beta1 (HRG-beta1)-mediated Matrix metalloproteinase (MMP-9)
expression in human breast cancer cells. Resveratrol significantly reduced the
incidence of poorly differentiated prostatic adenocarcinoma by 7.7-fold in an
animal study. A microarray gene expression study suggested that resveratrol
is a potent inhibitor of A549 lung cancer cell growth. However, a phase I study
suggests that consumption of high-dose resveratrol might be insufficient to
elicit systemic levels commensurate with cancer preventive efficacy.
http://www.zhion.com/phytonutrients/Resveratrol_Cancers.html
Cardiovascular disease
Resveratrol is a phytoestrogen, potent antioxidant, reactive oxygen species
scavenger and metal chelators. Thus, it may have benefits of protection of
the cardiovascular system against ischemic-reperfusion injury; it may also
protect and maintain the intact endothelium, exhibits antiatherosclerotic
properties inhibits the LDL oxidation, suppress the platelet aggregation and
exhibits estrogen like action.
Diabetes
In 2001, Naderali EK and co-workers from University of Liverpool found
resveratrol (5-35 micromol/l) induced concentration-dependent relaxation of
mesenteric arteries preconstricted with noradrenaline (8 micromol/l) or KCl
(125 mmol/l) from both lean and dietary-obese rats.
Hyperglycemia, a symptom of diabetes mellitus, induces hyperosmotic
responses, including apoptosis, in vascular endothelial cells and leukocytes.
Hyperosmotic shock elicits a stress response in mammalian cells, often leading
to apoptotic cell death. Moreover, resveratrol was found to attenuate high
glucose-induced apoptotic changes by virtue of its antioxidant property.
Resveratrol administration ameliorates common DM symptoms, such as body
weight loss, polyphagia, and polydipsia. In STZ-nicotinamide DM rats,
resveratrol administration significantly decreased insulin secretion and
delayed the onset of insulin resistance.
Researchers, at Boston University Medical Center, revealed inactivation of
hepatic AMP-activated protein kinase was a key event in the pathogenesis of
hyperlipidemia in diabetes (based on a study of in type 1 diabetic LDL
receptor-deficient mice). They showed that resveratrol could lower lipid levels
by activating AMP-activated protein kinase. It was about 200 times the potency
of Metformin!
http://www.zhion.com/phytonutrients/Resveratrol_Diabetes.html
Fatty Liver
The prevalence of nonalcoholic fatty liver disease is high.nonalcoholic fatty
liver disease is linked to obesity, diabetes mellitus, and hypertriglyceridemia.
Approximately 20% of patients with nonalcoholic fatty liver disease will
eventually develop cirrhosis. Resveratrol was found to decrease nonalcoholic
fatty liver disease severity in rats. This effect was mediated, at least in part, by
tumor necrosis factor alpha (TNF-alpha) inhibition and antioxidant activities.
http://www.zhion.com/phytonutrients/Resveratrol_Diabetes.html
Pancreatitis
Because microcirculation occlusion and cytokines over-production is involved
in many diseases such as acute pancreatitis, resveratrol as a platelet and
cytokines inhibitor may have benefits on acute pancreatitis.
Liver transplant
Resveratrol has been shown to have an immuno-suppressive property as well
as protective effect on hepatic under alligator rejection in a study of
Wistaria rats.
Kidney Disease
Resveratrol (RSV) has been shown to reduce ischemia-reperfusion (I/R) injury
of rat kidney both by antioxidant and anti-inflammatory mechanisms.
Sperm Production
In a study, researchers administered 20 mg/(kg . d) of trans-resveratrol for 90
days. Compared to a control group, the diameter of the seminiferous tubules
was significantly reduced from 437.5 +/- 0.1 mum in the controls to 310.9 +/-
0.1 mum. This decrease was accompanied by a significant increase in tubular
density. Sperm counts were significantly greater in the resveratrol-treated rats
than in the control group, but sperm quality did not differ.
Resveratrol is a natural substance in found in red wine, Japanese Knot weed, Cocoa, and peanuts. It provides a number of health benefits:-
Increased levels of energy and better muscle health. In the laboratory tests mice on resveratrol ran twice as far on a treadmill than mice not on resveratrol. Tests showed that wine resveratrol increased muscle tissue oxygen consumption in these lab mice and there was an increase in the number of mitochondria in their muscle tissue. What that means in laymans terms is that if you regularly take resveratrol it can effectively transform your muscles to resemble those only usually found in trained athletes. Perhaps another interesting effect may be that of the Sirtuins, enzymes which become less powerful with aging. Evidence shows that resveratrol may in fact trigger these sirtuins, therefore strengthening them and so assist in warding off degenerative disease.
Better heart health. There have been studies which reveal that red wine drinkers have approximately 50% the risk of heart disease than those that dont drink any red wine. The resveratrol is protective against cholesterol.
Improved brain and kidney health. Spanish researchers investigated the red wine health benefits by monitoring lab mice fed a high-cholesterol diet and then one which also included resveratrol. They concluded that red wine may protect the brain and kidneys against oxidative stress and high blood cholesterol.
Improved prostate health and a more regular urine flow. A University of Alabama study found a reduction in the development of prostate cancer in mice by 87%, in addition a slowing of the cancers progression, all by the mice being fed resveratrol
Improved breast health in women. Research so far, with animals, shows that resveratrol inhibits the development of esophageal, intestinal and mammary (breast) cancer. This resveratrol link to breast cancer is hugely significant because it means that resveratrol could slow or stop the progression of breast cancer, because breast cancer is usually caused by increased estrogen levels. Im sure youre aware or the importance of this as breast cancer is the 6th biggest cause of death and is the most common kind of cancer amongst women in America.
Improved cell protection. When resveratrol is added to cells, it has been found to inhibit the production of several human cancer cell lines, including those from breast, prostate, stomach, colon, pancreatic and thyroid cancers.
Antioxidant supplement. Take a proactive approach to reducing your risk by eating a balanced diet, exercising and supplementing with antioxidants like resveratrol, which science has shown to provide protection against many cancers and ailments.
Anti aging supplement. Resveratrol may be amongst the most important anti-aging supplements ever discovered. Initial research on fish and non-invertebrates that have taken resveratrol show increased life-spans of between 33%-60%. Researchers have said that adding small amounts of resveratrol to diets of middle-aged mice significantly slowed their aging and kept their hearts more healthy and when mice were given higher doses with a high-fat diet, it staved off premature death. Researchers also understand that resveratrol actually can extend life in the same way that calorie restricted diets do. This happens when the body is activated at a genetic level to produce Sirtuin 1, an enzyme involved in cellular regulation.
Resveratrol may be protective against lung cancer. Between 2000 and 2003, Dr. Chun Chao studied members aged 45 to 69 at Kaisers California Mens Study. There she identified 210 cases of lung cancer and measured the effect of beer, red wine and white wine consumption on the risk of lung cancer. With each glass of red wine consumed per month she found that there was a 2 percent lower chance of lung cancer, but there was no benefit when they drank white wine or beer. The highest risk reduction was the smokers who drank 1 2 glasses of red wine every day. In tests with mice that were given resveratrol supplements, the compound retarded lung cancer growth and also induced lung cancer cells to commit apoptosis.
Resveratrol may reduce liver disease. Resveratrol reduced the amount of fat produced in the liver of mice fed alcohol and increased the rate at which the liver fat was broken down. Heavy drinking of alcohol will cause fat to accumulate in the liver which can lead to cirrhosis, fibrosis, and other liver diseases. Previous studies show that chronic alcohol drinking inhibits the 2 proteins (AMPK and SIRT1) which are significant in the breakdown of fats in the liver. This allows fats to build-up. Fresh USA studies support the premise that the protective wine health benefits of a glass of red wine a day could actually protect against liver disease. And as we now know there is a link between the great health benefits of wine to that of wine resveratrol, which is a powerful natural polyphenol and anti fungal chemical which occurs under the skin of red wine grapes. Non-Alcoholic Fatty Liver Disease (NAFLD) which was almost totally unknown over 20 years ago, is now the most common liver disease in America, which affects in excess of 40 million adults and is expected to grow worldwide as nations become increasingly obese. For those who took red wine resveratrol (antioxidant supplement) daily reduced the odds of having suspected NAFLD by 50 per cent. By contrast, people who consumed only modest levels of beer or spirits had over four times the odds of having suspected NAFLD.
Resveratrol could reduce colon cancer risk. A recent Californian study found that low doses of freeze-dried grape powder (resveratrol powder) could actually inhibit the development of colorectal cancer. This is due to the polyphenols and synergistic effects between the grape compounds. This follows a 2006 study which found that resveratrol could reduce colon cancer risk by 67%
People have a long standing debate on how much alcohol a person should have everyday. Some people do not believe that red wine is a good source of health benefits, while other doctors and nutritionists believe it is. The resveratrol chemical is what they believe to carry the health benefits not the alcohol. While other foods such as peanuts carry resveratrol the amount is nothing compared to that in the grapes of red wine.Some of the most abundant natural sources of this would be the muscadine, labrusca, and vitis vinifera species of grapes.
The more grapes used in the fermentation process of the wine the higher the resveratrol concentration will be. Since a large quantity of grapes skin is significantly removed from the production of white wine, red wine becomes the most useful and reliable source of resveratrol. Resveratrol is a natural part of the defence system of plants, and is mainly responsible for the protection of plants against certain diseases. Thats why the antioxidant properties of resveratrol can also be made to form a part of our own defence system.
Resveratrol is used in several Japanese and Chinese medications that are used for treating allergy, fungal, lipid and other diseases. Resveratrol has been tested to drop heart diseases in humans through the use of consuming a lot of red wine.
Despite their diets which are high in saturated fat, the French have been proven to have a reduced risk of heart disease. The resveratrol in the grapes of the red wine must have had an impact on this fact. Alcohol consumption is never recommended but there is no proof of any side-effects of drinking red wine in moderation. Cancer-prevention is another benefit that is currently being researched in resveratrol.
Resveratrol is also believed to be the anti aging secret of centenarians who proliferate in cool climates and places abundant in production of grapes since this particular enzyme is said to have anti aging properties. Drinking red wine moderately can make an older person look younger and healthier. This can make older people look and feel younger.
1-2 glasses of red wine is the recommended daily dose and can reduce the risk of cardiovascular disease. Exceeding 1-2 glasses of red wine daily is not recommended because the negative effects of alcohol will outweigh the positive effects of resveratrol.
When you think of a treatment for diabetes, and you probably think of a drug or natural therapy that targets the pancreas to help normalize blood sugar levels. Resveratrol, a phytochemical found in red grapes, has been shown to have a host of health benefits -- including improving diabetes in animal studies. But, it turns out, that's not necessarily because it benefits the pancreas. Instead, scientists have made an unexpected discovery: resveratrol's anti-diabetic properties appear to be mediated through the brain.
That's the conclusion of a study conducted by scientists at the University of Texas Southwestern Medical Center in Dallas, Texas, that was just published in Endocrinology, a journal of The Endocrine Society. The researchers focused on sirtuins, a class of proteins activated by resveratrol that are thought to underlie many of the potential beneficial effects of calorie restriction, including promoting longevity and slowing down the aging process.
Early studies in mice have produced important evidence showing that when resveratrol activates sirtuins, diabetes is improved. While sirtuins are expressed virtually all over the body, until now researchers have remained in the dark about what tissues could be mediating resveratrol's beneficial effects on the disease.
"We know that sirtuins are expressed in parts of the brain known to govern glucose metabolism, so we hypothesized that the brain could be mediating resveratrol's anti-diabetic actions," said Roberto Coppari, PhD, of the University of Texas Southwestern Medical Center and co-author of the study, in a statement to the media. "To test the hypothesis, we assessed the metabolic consequences of delivering resveratrol directly into the brain of diabetic mice. We found that resveratrol did activate sirtuins in the brain of these mice which resulted in improving their high levels of blood sugar and insulin. These findings may lead to new strategies in the fight against type 2 diabetes."
Dr. Coppari and his research team discovered that long-term infusion of resveratrol into the brains of diet-induced obese and diabetic mice normalized the animals' hyperglycemia (high blood sugar) and greatly improved the rodents' hyperinsulinemia (excess levels of circulating insulin in the blood). The scientists noted in their research paper that these beneficial effects were independent of changes in the lab animals' body weight, food intake, and circulating levels of leptin (a hormone that helps regulate appetite and metabolism).
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A 30-day supply of Vivix delivers the equivalent amount of resveratrol found in 3,000 glasses of red wine, and Vivix ingredients were shown in a laboratory study to be 10x more powerful in slowing a key mechanism of aging than resveratrol alone.*
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Resveratrol has become well known for the many health benefits it provides and anti aging is one of the well known benefits due to all the media coverage about Resveratrol in the last couple years. One of the greatest reasons why Resveratrol has been an effective anti aging supplement is that it has been able to repair and renew cells because of the amazing amount of phytonutrients and antioxidants.
Resveratrol also mimics a low calorie diet, speeds up metabolism and protects against oxidative stress. Fighting off stress is actually a huge health benefit for all the damage stress can do itself. Stress been well document to cause additional strain and harm to both the body and emotions, which can then cause heart disease and other health issues.
Weight loss has been another benefit people have experience when taking Resveratrol supplements. Just having the abilities to fight off stress and aid in weight loss can help people live longer and healthier making it one of the very best anti aging supplements available along with Coq10 and Omega 3 fish oil.
Many North Americans experience a low level of health and if you feel tired all the time and experience different health issues, you may want to consider looking to the health benefits of Resveratrol. Whether you want to lose weight, reduce stress, or slow down aging while protecting yourself from other health issues it is something that can help you live healthier and enjoy a vibrant life.
In a US Department of Agriculture (USDA) laboratory at Tufts University in Boston, researchers have found that blueberries rank #1 in antioxidant activity when compared to 40 common fresh fruits and vegetables. Blueberries have the highest antioxidant capacity of all fresh fruit, and thus have the highest capacity to destroy free radicals. Blue Berries are very rich in anti oxidants like RESVERATROL, anthocyanin, vitamin C, B complex, vitamin E, vitamin A, copper, selenium, zinc and iron. They boost up your immune system and prevent infections. Medical research has also proven that resveratrol can act as an anti-inflammatory agent.
Resveratrol has antidepressant and anti-anxiety agents which contain monoamine oxidase inhibitors. Resveratrol will increase your stamina and give you a shot of energy enabling you to athletically perform better.
A University of Michigan Cardiovascular Centre study suggests that blueberries may help reduce belly fat and risk factors for cardiovascular disease and metabolic syndrome. Resveratrol will boost your metabolism and suppress your appetite aiding you in your weight loss goals. It also helps promote healthy urinary tract function, preserves vision, proper brain and heart function, and reduces the risks associated with cancer.
The findings suggest that resveratrol may contribute to the inhibition of primary tumour growth and metastasis to distant organs through the inhibition of DNA synthesis of tumour cells by resveratrol.
Harvard researchers believe theyve discovered a proverbial fountain of youth. Theyre talking about resveratrol, a powerful antioxidant found in blueberries, calling it a miracle ingredient, and the greatest discovery since antibiotics. There is evidence that resveratrol can extend lifespan. It also helps you lose weight, is anti-fungal, antiviral and acts as an anti-biotic, and helps you maintain a healthy brain. We have something that extends the life of every species its given to, said David Sinclair, a researcher at Harvard Medical School.
Remember, the deeper the colour of the Blue Berries, the more they are rich in anti oxidants and other medicinal values.
Resveratrol is a broad name of a product that is available in various purities (e.g. 5%, 10%, 20%, 50%, 99%, etc.). Pure resveratrol contains only trans-resveratrol, the beneficial substance in resveratrol. Low purity resveratrol products contain low amounts of trans-resveratrol and high amount of CIS-resveratrol and Emodin, which has no health benefits.
In 1998 Scientists found that the compound resveratrol slows age-related deterioration and functional decline of mice on a standard diet, but it did not increase longevity when started at middle age. This study, conducted and supported in part by the National Institute on Aging (NIA), part of the National Institutes of Health, was a follow-up to 2006 findings that resveratrol improves health and longevity of overweight, aged mice. The report confirms previous results suggesting the compound, found naturally in foods like grapes and nuts, may mimic, in mice, some of the effects of dietary or calorie restriction, the most effective and reproducible way found to date to alleviate age-associated disease in mammals.
The findings, published July 3, 2008, in Cell Metabolism, increase interest in resveratrol as a possible intervention for age-related declines. The authors emphasized, however, that their findings are based on research in mice, not in humans, and had no immediate and direct application to people, whose health is influenced by a variety of factors beyond those which may be represented in the animal models.
The study was a collaborative effort between the laboratories of Rafael de Cabo, Ph.D., of the Laboratory of Experimental Gerontology at the NIA; David A. Sinclair, Ph.D., of the Glenn Laboratories for Molecular Biology of Aging at Harvard Medical School; and an international group of researchers. The investigators compared mice fed a standard diet, a high-calorie diet, or an every-other-day feeding regimen with or without high- or low-dose resveratrol to study the impact of resveratrol on aging and health. In previous studies, different forms of dietary restriction, including every-other-day feeding, have been shown to improve markers of health.
"Research is attempting to understand the process of aging and to determine how interventions can influence this process. Dietary restriction has well-documented health benefits in mammals, and the study of possible mimetics of it, such as resveratrol, are of great interest," said NIA Director Richard J. Hodes, M.D. "Resveratrol has produced significant effects in animal models, now including mice, where it mimics some, but not all, consequences of caloric restriction. Its effects in humans remain to be studied."
A major finding of the study reported at that time is that resveratrol prevented age-related and obesity-related cardiovascular functional decline in the mice as determined by several parameters. Total cholesterol was significantly reduced in 22-month-old non-obese mice after 10 months of resveratrol treatment, although triglyceride levels had only a slight, non-significant trend toward a decrease. Further, the aortas of 18-month-old obese and non-obese mice treated with resveratrol functioned significantly better than untreated mice. Resveratrol also moderated inflammation in the heart.
In addition to cardiovascular function, the scientists found resveratrol to have a variety of positive effects on other age-related problems in mice:
Treated mice tended to have better bone health, as measured by thickness, volume, mineral content and density, and bending stiffness compared to the non-treated control group.
At 30 months of age, resveratrol-treated mice were found to have reduced cataract formation, a condition found to increase with age in control-group mice.
Resveratrol enhanced balance and motor coordination in aged animals. Scientists found significant improvement in performance at 21 and 24 months versus 15 months in the resveratrol-treated mice but not in the untreated mice.
Resveratrol partially mimicked the effects of dietary restriction on the gene expression profiles of liver, skeletal muscle and adipose (fatty) tissue in mice.
Along with determining the effect of resveratrol on the health of mice, scientists also studied the effect of resveratrol on longevity.
"We found that while quality of life improved with resveratrol, the compound did not significantly affect overall survival or maximum lifespan for mice on a standard diet, compared to mice on the same diet without resveratrol," said de Cabo.
Resveratrol did not have a significant effect on lifespan in animals fed standard chow, suggesting that the intervention did not affect all aspects of the basic aging process. Mice on a high-calorie diet without resveratrol lived the shortest length of time and mice on an every-other-day regimen lived the longest, regardless of resveratrol treatment. However, for mice on a high-calorie diet, mean and maximum lifespan increased for mice on resveratrol when compared with the control mice. Researchers found that resveratrols effects on longevity could be completely uncoupled from changes in body weight, meaning that mice on a high-calorie diet with resveratrol did not necessarily lose weight but did experience a longer (and healthier) life than mice on the same high-calorie diet not taking resveratrol. They speculate that improved cardiovascular health and reduced fatty changes in the liver may have contributed to the increased lifespan of resveratrol-treated mice.
Researchers still have much to learn before resveratrol can be recommended for human use. Basic questions of safety and biological effect in humans remain to be studied experimentally.
In addition to scientists from the NIA and Harvard Medical School, researchers from the following institutions collaborated in this study: New York Medical College, Valhalla, N.Y.; University of Michigan, Ann Arbor; University of Sydney in Australia; Thomas Jefferson University, Philadelphia; University of California, San Diego, La Jolla; Hospital for Special Surgery, New York, N.Y.; University of Cincinnati, Ohio; University of Texas Health Science Centre at San Antonio and Audie Murphy VA Hospital, San Antonio, Texas; Universidad Pablo de Olavide, Sevilla, Spain; Pennington Biomedical Research Centre, Baton Rouge, La.; University of Washington, Seattle; and Sirtris Pharmaceuticals of Cambridge, Mass., a company founded by Harvard University co-lead author Sinclair.
De Cabo is a scientist in the NIAs Intramural Research Program. In addition, the research was funded by grants from the NIA, the primary supporter of the work, as well as grants from the National Institute of General Medical Sciences; the National Heart, Lung, and Blood Institute; the National Institute of Child Health and Human Development; the National Eye Institute; and the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the NIH. The Ellison Medical Research Foundation, the American Heart Association, the Australian and Spanish governments and Paul F. Glenn and The Paul F. Glenn Laboratories for the Biological Mechanisms of Aging also provided support to members of the research team.
The NIA leads the federal government effort conducting and supporting research on the biomedical and social and behavioral aspects of aging and the problems of older people.
Various studies have shown that resveratrol, an ingredient found in red wine and also in the medicinal plant, Polygonum cuspidatum (Japanese Knotweed), can prolong the life of brewers yeast by 60%, worms by 15%, fruit flies by 29% and rodents by 31%.
Resveratrol studies have shown that it has multiple health benefits that help reduce the risk of many age-related degenerative diseases. Taking resveratrol may help you live longer and healthier.
Live Longer?
In early 2006, Italian researchers discovered that resveratrol can extend the life span of turquoise killifish by 50%. Killifish lives only three months when in captivity.
The results showed that adding resveratrol to the daily diet prolonged their expected life span. The fish study is interesting because fish, a vertebrate, is far above yeast, worms and fruit flies in the evolutionary tree. The study also showed resveratrol slowed the progression of fish muscular problems as they grew older.
Resveratrol Research shows its ability to activate the longevity gene helps to prolong life. Resveratrol activates the same longevity gene expressed during caloric restriction, the only proven way of extending life span.
So far, resveratrol studies showing the ability to extend life span are confined to lower organisms and fish.
Unfortunately resveratrol studies on humans will take more than 100 years to complete. Since we share many genes in common with even the simplest organisms such as bacteria and worms, it is likely that the studies in animals may have similar results in us.
Healthier life
What is also interesting about resveratrol is that it has many other beneficial health properties, such as antioxidant, anti-inflammatory, and other activities. These properties represent many of the known risks for developing different age-related degenerative diseases.
Resveratrol studies have shown that it has many other beneficial health properties such as:
Antioxidant acts against damaging free radicals
Anti-inflammatory agent
Reduces blood pressure promotes relaxation of blood vessels
Reduces menopausal symptoms mood swings, hot flushes etc on
Reduces risk of developing Alzheimers disease
Reduces risk of developing blood clot
Reduces risk of developing diabetes
Resveratrol and cancer
Cancer is, perhaps, the most dynamic area of resveratrol research. Resveratrol is the first natural medicinal to have solid evidence behind it showing that it blocks or stops many stages of cancer.
Resveratrol has been proven to fight cancer in vitro at all three stages: initiation, promotion, and progression. Resveratrol not only prevents cancer, its being proposed as an additional treatment.
The National Institutes of Health (NIH, US) has sponsored a clinical trial investigating resveratrols ability to fight colon cancer.
Benefits for heart and blood vessel health
Resveratrol is thought to underlie the French Paradox, which refers to the low levels of heart disease found in France despite a population renowned of its love of wine and fatty food.
Resveratrol has been found to exert a number of potentially cardio protective effects including:
Increases levels of high-density lipoprotein (HDL) or good cholesterol, which protects against heart disease.
Prevents low-density lipoprotein (LDL) or bad cholesterol from being oxidised by free radicals and it is the oxidised LDL that forms plaque that can lead to atherosclerosis, or hardening and thickening of the arteries.
Inhibits platelet aggregation as it prevents blood cells from sticking to each other and forming clots. These clots can become lodged in a small vessel of the heart, causing heart attack, or lodged in the vessel of the brain, causing a stroke.
Promotes vasodilatation by enhancing the production of NO (nitric oxide), which allows the blood vessels to relax, resulting in enhanced blood flow.
Alzheimers prevention
Resveratrol studies suggest that it might help prevent or ease (ameliorate) Alzheimers disease.
One of the characteristics of Alzheimers disease is the deposition of plaques in the brain. These plaques are caused by amyloid-beta peptides.
One laboratory study showed that administering resveratrol to cells decreased their secretion and cells levels of amyloid-beta peptides. Resveratrol did not inhibit the production of amyloid-beta, but instead promoted its breakdown in the cells.
Although preliminary, these findings suggest a potential role for the compound in fighting the accumulation of amyloid-beta plaques in the brains of Alzheimers sufferers.
Brain damage in stroke victims
For years, scientists have advocated drinking a glass of red wine once or twice a day to help with cardiovascular health, said Grace Sun, a professor of biochemistry and part of a husband-wife research team at University of Missouri-Columbias School of Medicine.
Our research has shown that a compound in red wine or grapes resveratrol can have a similar impact on brain health, and in some cases, may help minimise the damage to the brain when a stroke occurs.
Other benefits
Other resveratrol benefits include doubling exercise endurance and also protecting mice from ill effects of obesity.
Resveratrol enabled mice that were fed with a high-calorie, high-fat diet to live normal, active lives despite being obese the first time any compound has been shown to do that.
Resveratrol may also offer benefits in preventing or managing conditions associated with high blood sugar, such as metabolic syndrome or diabetes.
Dr David Sinclair, leader of the Harvard resveratrol study, conducted a clinical trial to evaluate resveratrols effects in controlling blood sugar in patients with diabetes.
All the above mentioned properties are very exciting because they represent many of the known risks for developing different age-related degenerative diseases.
It is important to understand that there are many other risk factors associated with diseases and that taking resveratrol may be one of the many important steps in risk reduction.
Most women and some men have always tried to improve their appearance, from fragrances, perfumes to old fashioned make-up our ancestors and forefathers took care of their own appearances and spent the time to further improve themselves.
Those days of quietly growing older have died. Most people seek to prevent growing older, in all the meanings of this: body, mind, or soul.
Lured by photographs in publications of airbrushed models who show up more youthful as well as perfect, people in todays world tend to be getting obsessive about appearance. If you look up search engines for how to look young, 13,800,000 results pop up! There is so much information online about how precisely to turn back again the hands of time with your appearance.
Creams, makeup foundation methods, medical procedures as well as face yoga exercises all people have some advice to help you appear younger. Morley Safer did an investigation titled Fountain of Youth in a Wine Rx? which examined the influence of resveratrol on anti-aging. Resveratrol is packed with antioxidants, many which studies display to be especially useful when you are combating aging. Scientific studies on animals indicated that the life expectancy on which the product has been tested, was improved and also their standard of living whenever routinely offered resveratrol in comparison with their counterparts not offered resveratrol.
Whenever any of these animals (mostly rats and mice) passed away, the study of bodily organs uncovered much more. The mice which got resveratrol not just lived more time yet on autopsy had healthier, youthful internal organs compared to those which didnt have some resveratrol.
Scientific studies on resveratrol anti-aging properties are in their beginning. I have been taking Resveratrol for some months now and am beginning to see some effects, I am losing a bit of wight and feel I have more energy.
Resveratrol has become a regular supplement for many people over the past few years. It offers protection against heart disease and aging and other related related diseases. It can also offer an excuse to drink more red wine! Resveratrol supplements have been tagged as anti-aging. Recent research and studies have weeded out some of the hype. What remains are less spectacular but valid health benefits.
Why the great Interest
Resveratrol's claim to fame was the result of trying to solve the "French Paradox". The rich high fat French cuisine accompanied by low heart disease and obesity rates among the French just didn't make sense. After isolating resveratrol from red wine, this assumption was made: The French consumed enough wine containing resveratrol to offer immunity from heart disease despite their high fat diets.
Subsequent studies have shown that the amount of resveratrol from red wine consumption may not be enough to explain the "French Paradox". But there is still nutritional merit in resveratrol along with the other foods containing it.
Those other foods include Japanese Knotweed root for teas, muscadine grapes (seeds and skins), grape juice, cocoa and dark chocolate, peanuts, blueberries, cranberries and red carrots. Their resveratrol content levels from highest to lowest are pretty much in the order listed.
Resveratrol Dosage
Even if you eat all the above foods on a regular basis you probably won't get enough resveratrol to dramatically impact your health to the level of earlier hype on inhibiting cancer, heart disease, and Alzheimer's. These foods do contain other beneficial phytonutrients and antioxidants, which do offer positive synergistic effects with resveratrol to slow aging issues.
But perhaps concentrated resveratrol supplements can meet those earlier expectations. Many of the resveratrol supplements are extracted and concentrated from the Japanese Knotweed plant and grapes. So at least they are mostly food based supplements. It seems home made tinctures made from bulk Knotweed roots would be cost effective, but for now most of the Knotweed is contracted out to supplement companies. What's left goes for top dollar, unless you have it in your back garden.
The Japanese and Chinese have benefited from resveratrol for centuries by using Knotweed for teas. But it wasn't until the 1980s that the active phytonutrient resveratrol was isolated. Resveratrol is a chemical that spermatophyte (seed producing) plants create to ward off attacking fungi and bacteria. So it's ironically logical that plants from regions with the most fungi and bacteria exposure have the highest concentrations of resveratrol! Where the plants are grown is almost as important as the type of plant grown.
This may also highlight the eminence of organic. If synthetic fertilizers, pesticides and insecticides are used to keep the plants from being attacked by fungi and bacteria, those plants probably produce less resveratrol. But the toxic poisons do get passed on to you. Peanuts, high in resveratrol, are among the most heavily sprayed plants. So it's especially important to go organic with peanuts and peanut butter.
Mice get all the breaks. Scientists continue testing the benefits of resveratrol on them.
In this one study at the University of Wisconsin-Madison, results indicate that the chemical resveratrol, commonly found in red wine, can help keep heart tissues young and delay agingand at levels lower than previously expected. In fact, researchers believe that a glass of red wine a day might provide all the resveratrol the heart needs.
Delaying the effects of aging on the heart is huge; the aging process itself apparently causes more health issues than age-related diseases. In tests on middle-aged mice [did that phrase make you smile too?], the hearts of the mice on resveratrol stayed stronger and the tissue maintained its health longer.
Resveratrol has been known for some time to offer significant health benefits, but previous studies involved levels of resveratrol found in hundreds of bottles of wine. If this latest study is correct, one or two glasses of red wine a day could actually prevent changes in heart cells that lead to aging.
Red wine-based pharmaceuticals are suddenly becoming big business, as companies aim to cash in on these findings with resveratrol supplements. Theyre already commercially available. Personally, it sounds like an answer for which there was no question, to quote a former boss. I mean, a nice glass of Cabernet versus a pill? No contest, as far as I can see.
The first and least exciting method to lengthen your life is caloric restriction. So far, this is the only method that everyone agrees works. The basic idea is that you reduce the amount of calories (food) you take in on a daily basis. How does this help you live longer? Well, when you live on just the minimum calories your body needs (and you do it consistently), your cells go into starvation mode and make themselves hardier and less prone to disease. Thats the leading theory anyway. This usually translates to a 50% longer lifespan.
The second method is to take Resveratrol. In a famous study by Harvard University, the effects of resveratrol can be clearly seen.
We report a striking transcriptional overlap of CR and resveratrol in heart, skeletal muscle and brain. Both dietary interventions inhibit gene expression profiles associated with cardiac and skeletal muscle aging, and prevent age-related cardiac dysfunction. Dietary resveratrol also mimics the effects of CR in insulin mediated glucose uptake in muscle. Gene expression profiling suggests that both CR and resveratrol may retard some aspects of aging through alterations in chromatin structure and transcription.
In mice fed a high calorie diet, but supplemented with resveratrol, they showed a significant increase in balance and motor coordination. They had a higher quality of life than the mice without the resveratrol According to scientific studies, resveratrol has been shown to lengthen the lifespans of yeast and fish by 60%.
We made a striking observation, says Sinclair. Resveratrol opposed the effects of high caloric intake in 144 out of 153 significantly altered pathways. In terms of gene expression and pathway comparison, the resveratrol fed group was more similar to the standard diet fed group than the high calorie group.In humans, high calorie diets can increase glucose and insulin levels leading to diabetes, cardiovascular disease, and non-alcoholic fatty liver disease. In the HC fed mice, researchers found biomarkers that might predict diabetes, including increased levels of insulin, glucose and insulin-like growth factor-1 (IGF-1). Conversely, the HCR fed group had significantly lower levels of these markers, paralleling the SD group.
Organ Protection: Heart and Liver
Three pathologists examined heart tissue from the SD, HC, and HCR mice, and while not knowing which organ belonged to which mouse group, they looked for subtle changes in the abundance of fatty lesions, degeneration and inflammation. On a relative scale of 0-4, the assessment produced mean scores of 1.6 for the SD group, 3.2 for the HC group, and 1.2 for the HCR group. R also activates the SIRT1 gene, that helps increase longevity.At 114 weeks, when the mice reached old age, more than half of the high calorie mice died compared to less than a third of the high calorie mice receiving resveratrol. The overweight resveratrol-treated aged mice were healthier than the overweight mice that were not given resveratrol on a number of measures. For example, the untreated high calorie mice had increased plasma levels of insulin, glucose and insulin-like growth factor (IGF) 1 markers that in humans predict the onset of diabetes when compared with their overweight counterparts who did receive resveratrol. In November 2008, researchers at the Weill Medical College of Cornell University reported that dietary supplementation with resveratrol significantly reduced plaque formation in animal brains, a component of Alzheimer and other Neurodegenerative diseases.
The third method is cloning and body part replacement. This has been used for years, in some sense. The first artificial heart was implanted in 1982. Organs from Pigs and other animals have also been used successfully, but the best replacement is from a human. One major issue with organ transplants is that sometimes the host body rejects the new organ because it sees it as a foreign invader. Cloning would solve this problem. If you need a new heart, have one custom grown for you using your own DNA. That way, when its installed, your body would accept it as part of yourself with no problems. Scientists have been able to grow individual organs, so the scenario in the movie The Island where a complete clone is kept for organ harvesting for rich people, would be avoided. However, sometime in the future, we may be able to grow a full grown clone without consciousness, so that once we can capture and transfer consciousness, would make switching bodies like putting on a new pair of running shoes and throwing out your old, worn out ones.
A fourth method is cryonics. Basically you freeze yourself. You would only use this method if you had some incurable disease in the hopes that at some point in the future, they would 1) be able to thaw you out and bring you back to life. and 2) cure whatever disease you were going to die from.
There are two main problems with this approach right now. One is that if you freeze a normal human body, the water in your blood and cells will expand during freezing and rupture your veins and tissues. When they thaw you out, youll be a mushy, leaky, bloody mess. The solution would be to replace all the fluids in your body with antifreeze, prior to freezing. Its not as crazy as it sounds. People have already successfully vitrified a rabbit kidney, then thawed it and transplanted it into a live rabbit.
The other problem is that right now, society wont let a scientist help freeze your body while you are still alive. If you had a brain tumour and knew you would be dead in a year, you would want to freeze your body before the tumour expanded throughout your brain causing massive damage. You would want to freeze your (relatively) healthy body so there would be less damage that the future doctors would have to repair. But as it stands now, you would have to wait until you died from your disease, before your body could be frozen. Maybe a change in the language of assisted suicide could help this issue. Because its not suicide, you see, its just pushing the pause button.
Yet another method is mind uploading. This is the farthest out there in terms of technology. If computers continue to follow Moores Law (computing power doubles every two years), in 50 years, we should have the means to make a computer as complex as the human brain. Then we would just have to figure out how to take a realtime scan of a persons brain, noting the precise location of every synapse and neuron. The remaining step would be to recreate that setup in silicon and if everything goes right, we would have a copy of your consciousness in a computer. Then the fun starts. You could replace your body with a robotic one and run your brain through the advanced hardware. But would you be human anymore?
For now, Ill stick to eating healthy, exercising, and taking Resveratrol.
Obesity is a developing worldwide problem so it will come as no surprise to read that much of the population is focused on weight loss. There are weight loss supplements, weight loss frozen meals, cookbooks for weight loss, not to mention companies like Weight Watchers and Slim Fast. It is also no surprise to anyone that the process of losing weight is not a lot of fun. Anyone who has ever tried to lose weight will tell you that they are always looking for the final solution to their weight problem. One possible solution to aid the ever vigilant weight loss seeker is adding resveratrol to your daily diet.
Resveratrol does not appear to directly cause weight loss. However, resveratrol exhibits several properties which will aid the hopeful dieter in achieving their weight loss goal. Resveratrol is a compound found naturally in the skin of grapes, particularly in red grapes. Red wine, grape juice made with red grapes, raspberries, blueberries, cranberries, Cocoa and peanuts contain resveratrol naturally. If you are trying to lose weight, you might not want the added calories from some of these foods, so resveratrol supplements could be helpful as part of your plan to lose weight.
Resveratrol found in supplements can boost your weight loss because resveratrol is an antioxidant. Some research surrounding antioxidants shows that antioxidants could play a role in helping your bodys metabolism to work more efficiently. If your metabolism is operating at optimum efficiency, you will be able to burn more calories, not only when you are exercising, but even when you are sitting still! If you combine a low calorie diet with increased exercise, and your metabolism is working more efficiently from antioxidants like resveratrol, you increase your chances that you will lose weight.
If your metabolism is working more efficiently, you will feel like you have more energy. The resveratrol could rev up your metabolism, so you will be more energized for exercising. If you can exercise more with the increased energy, you will be more successful in losing weight. Consuming higher amounts of resveratrol either naturally by eating grapes or by taking resveratrol supplements could help you feel more energetic.
Some research has shown that resveratrol can help stabilize the level of blood sugar. The level of sugar in your blood is not constant. After a meal, blood sugar levels are high. When you have not eaten for awhile, the level of sugar in your blood is lower. This lower level of blood sugar can trigger a feeling of hunger and result in eating. If your blood sugar levels can be stabilized, you will reduce those hunger pangs and eat less frequently. If you are not hungry, you will eat less, and if you are monitoring your portion sizes when you do eat, you will lose weight.
Resveratrol has characteristics which could help in weight loss. If you exercise and control the portions of food you eat in order to reduce caloric intake, resveratrol could help you control your appetite between meals by helping to stabilize blood sugar levels. You might get a boost to metabolism from the antioxidant food that contains resveratrol. You have nothing to lose by trying resveratrol except weight!
There are many studies concerning resveratrol and cancer elimination. Whenever scientists find some new antioxidant, they start conducting studies. As time passes, there will be other scientists with inconsistent data. Why?
Scientists use various procedures. Sometimes, their studies dont seem sound. It is actually hard to check data from one group to the close to due these differences. When scientists discover ways to make synthetic versions of naturally occurring nutrients, they choose those for their studies. They may be molecularly close and even identical, there is however no reason to believe that synthetics act in the same way that normally occurring substances do.
The majority of the synthetics are manufactured using petrochemicals, that happen to be toxic to the human body. The opinions of the researchers, themselves, affect the outcome with the studies, whether their thoughts are positive or negative.
There will always be groups that say the evidence concerning resveratrol and cancer avoidance is not yet proven. But wait , how can we actually prove similar to cancer-prevention in humans? Would we find out number of people to obtain the supplement throughout their lives, and one group to be given a placebo, and wait to check the quantity of from each group developed some type of cancer? That would be unethical.
There is simply no doubt in my mind we now have things that we can perform to avoid numerous life-threatening diseases. We know very well what causes most of them. We learn about nutrients that address those causes. Therefore now you ask , why isnt everyone healthier?
Many people do not take supplements just because they dont believe in them. They feel they will probably get all nutrients they need daily through diet alone, which is probably a false assumption.
Some people who may have learned about resveratrol and cancer prevention often pick supplements that incorporate the wrong form, which happens to be trans-resveratrol. Or they pick a supplement that dont even have an enteric coating, therefore it never be in the bloodstream. Some of us take single-ingredient supplements, which cannot provide the main benefit of a multi-nutritional supplement.
When people do choose to take a multi-nutritional supplement, they look for the lowest priced ones. lowest price often contain synthetics. E.g., the form of vitamin E usually obtained in dietary supplements is totally synthetic, based on petroleum. The vitamin D that a lot of companies use is not D3, which happens to be the only real kind of the vitamin that the body are able to use.
For that health and total well-being of ones body, it is vital to prevent synthetics regularly.
Up to now, the many studies I read about resveratrol and cancer happen to be positive. I require a multi-nutrient supplement that includes resveratrol, green tea and also other extracts that contain anti-cancer activity. Furthermore , I avoid known toxins that are contained in the environment and increase the individuals risk of cancer. Like, I only drink purified water and I mostly eat natural foods.
Besides the resveratrol and cancer benefits, it might also lower your risk of coronary disease. But only if you choose the right supplement
What is all the fuss about living until youre 120? Do you even want to live so long? The answer for me is yes! My father is approaching 100, so I am kissing the ground that this anti-aging stuff (resveratrol) was invented during my life time. Now for the honest truth; effectiveness and cost are the critical issues.
First of all, our anti-aging supplement is resveratrol. However our product comes with an extra power punch. Developed after years of research by our scientists at the Corporation, our anti-aging supplement also has a unique blend of polyphenols that fight cellular aging that adds the extra boost of power. This mixture of blends and resveratrol bumps up the volume and makes our key ingredients 10X more powerful in slowing the key mechanisms of aging than resveratrol alone. Lets take at look at the key factors in aging.
WHY WE AGE
In scientific studies, the 4 Key Reasons Why We Age
1. Each day, every cell in your body is bombarded by up to a million DNA assaults making the aging process accelerate. Our anti-aging supplement ingredients help protect and repair cellular DNA.
2. Declining Cellular Energy Production. Mitochondria in our cells create energy we cant live without. As mitochondrial efficiency decreases, cell function declines. Vivix ingredients promote mitochondrial biogenesis.
3. Genetic regulators contribute to age related cellular deterioration. Vivix ingredients positively impact genetic regulators, which help turn down cellular aging.
4. Accumulation of AGE Proteins or advanced blycation end products may be responsible for cellular damage that can compromise cell integrity and longevity. Vivix ingredients are 10X more powerful than resveratrol along at slowing AGE protein formation.
Our powerful ant-aging formula also supports
Heart Health
Brain health
Cardiovascular function
Enhanced immunity
Joint health
All natural, clinically tested key ingredients, Our powerful and potent Anti-Aging serum is not a fly by night product, lets get it on the market quick supplement. Just one of our ingredients has been referenced in over 2,000 research publications, including multiple studies conducted by Harvard University, at the National Institute on Aging, at the National Cancer Institute, and the National Institute of Environmental Health Science. Naturally safe, proven and effective and 100% guaranteed many other references are included in the blog
A 30-day supply is reasonably affordable at (about $100)(Discounts available with auto ship & membership) delivers the equivalent amount of resveratrol found in 3,000 glasses of red wine. Just one teaspoon supplies the amount of resveratrol found in 100 glasses of red wine. Shop and compare, you will discover this is the best value based on potency and price.
Biologists found in 2003 a class of chemicals that they hope will make people live longer by activating an ancient survival reflex. One of the chemicals, a natural substance known as resveratrol, is found in red wines, particularly those made in cooler climates like that of New York.
The finding could help explain the so-called French paradox, the fact that the French live as long as anyone else despite consuming fatty foods deemed threatening to the heart.
Besides the wine connection, the finding has the attraction of stemming from fundamental research in the biology of aging. However, the new chemicals have not yet been tested even in mice, let alone people, and even if they worked in humans, it would be many years before any drug based on the new findings became available.
The possible benefits could be significant. The chemicals are designed to mimic the effect of a very low-calorie diet, which is known to lengthen the life span of rodents. Scientists involved in the research say that human life spans could be extended by 30 percent if humans respond to the chemicals in the same way as rats and mice do to low calories. Even someone who started at age 50 to take one of the new chemicals could expect to gain an extra 10 years of life, said Dr. Leonard Guarente of the Massachusetts Institute of Technology, one of the pioneers of the new research.
The result was announced in Aug 2003 at a scientific conference in Arolla, a small village in the Swiss alps, by Dr. David A. Sinclair of the Harvard Medical School.
The new development aroused the enthusiasm of many biologists who study aging, because caloric restriction, the process supposedly mimicked by the chemicals, is the one intervention known for sure to increase longevity in laboratory animals.
A calorie restricted diet includes all necessary nutrients but has some 30 percent fewer calories than usual. The diet extends the life span of rodents by 30 to 50 percent, and even if it is started later has a benefit proportionate to the remaining life span. Scientists hope, but do not yet know, that the same will be true in people.
A similar mechanism exists in simpler forms of life, making biologists believe that they are looking at an ancient strategy, formed early in evolution and built into all animals. The strategy allows an organism, when food is scarce, to live longer, postpone reproduction and start breeding when conditions improve.
Even if caloric restriction did extend people's life spans, the current epidemic of obesity suggests how hard it would be for most people to stick with a diet containing 30 percent fewer calories than generally recommended.
Biologists have therefore been hoping to find some chemical or drug that would mimic caloric restriction in people by activating the same genetic circuitry as a reduced-calorie diet does and give the loss without the pain.
Dr. Sinclair and his chief co-author, Dr. Konrad T. Howitz, of Biomol Research Laboratories in Plymouth Meeting, Pa., say they have succeeded in finding a class of drugs that mimic caloric restriction in two standard laboratory organisms yeast and fruit flies. Both mice and humans have counterpart genes that are assumed to work in a similar way, though that remains to be proved.
In an interview from Arolla, Switzerland, where he presented his findings, Dr. Sinclair said, "I've been waiting for this all my life," adding, "I like to be cautious, but even as a scientist, it is looking extremely promising."
So far, Dr. Sinclair and his colleagues have shown that resveratrol prolongs life span only in yeast, a fungus, by 70 percent. But a colleague, Dr. Mark Tatar of Brown University, has shown in a report yet to be published that the compound has similar effects in fruit flies.
Despite the years of testing to prove that resveratrol has any effect in people, many of the scientists involved in the research have already started drinking red wine.
"One glass of red wine a day is a good recommendation. That's what I do now," Dr. Sinclair said, adding he hoped the finding would not lead people to drink in excess. "One glass of wine is enough," he said. However, resveratrol is unstable on exposure to the air and "goes off within a day of popping the cork," he said.
Dr. Tatar, asked if he had changed his drinking habits, said, "No, I have always preferred red wine to white."
Health authorities have not yet had time to make a detailed evaluation of the research. Dr. David Finkelstein, the project officer at the National Institute of Aging, which financed the study, said that he would not advise anyone to start drinking red wine. "At this point, we have no indication that there will be a benefit in people," he said, adding that the calories in a glass of wine would lead to weight gain.
Dr. Toren Finkel, the head of cardiovascular research at the National Heart, Lung and Blood Institute, said that "I would be cautious in sending out the message that one glass of wine a day will make you live 10 years longer." "The concentration of resveratrol in different wine differs," he said. "As a drug, it is not ready for prime time." But he acknowledged that the concept of a drug that mimicked caloric restriction "is a great idea.".
Resveratrol is synthesized by plants in response to stress, like a lack of nutrients or contracting a fungal infection. It exists in the skin of both red and white grapes but is found in amounts 10 times higher in red wine because of differences in the manufacturing processes.
According to the Oxford Companion to Wine, Pinot Noir tends to have high levels of the resveratrol, while Cabernet Sauvignon has lower levels. "Wines produced in cooler regions or areas with greater disease pressure, such as Burgundy and New York, often have more resveratrol," the book says, whereas wines from drier climates like California or Australia have less.
Besides resveratrol, another class of chemical found to mimic caloric restriction is that of the flavones, found abundantly in olive oil, Dr. Howitz said.
The enthusiasm scientists are showing for the discovery, despite its preliminary nature, stems in part from a train of fundamental discoveries stretching back a decade. In 1991, Dr. Guarente decided to study the basis of aging, then considered an unpromising field of research. He spent four years searching for strains of yeast, a common laboratory organism, that lived longer than others. By 1997, he and Dr. Sinclair, who worked in his laboratory at the time, had discovered the reason for the new strains' longevity. It centred on a gene called sir2, for silent information regulator.
Dr. Guarente next found that when yeast live longer because of starvation, sir2 is the gene that mediates the response. His research then started to fuse with longstanding work on caloric restriction as he and others showed that starvation is sensed by sir2, which triggers the cellular changes that lead to increased life span.
What Dr. Sinclair and Dr. Howitz did was to take the human version of sirtuin, the enzyme produced by the sir2 gene, and devise a test to tell when the enzyme was activated. They then screened a large batch of likely chemicals to see if any made the enzyme more active. Their screen produced two active chemicals, both of a similar chemical structure and known as polyphenols. That led them to expand the search to more polyphenols. The most active compound in the second screen was resveratrol. Dr. Sinclair said he was amazed "that in an unbiased screen we pulled out something already associated with health benefits."
Much attention has been paid to resveratrol in the last few years because it is a candidate for explaining the apparent innocuousness of the French diet despite its artery-weakening ingredients. Epidemiological studies point to red wine as containing some beneficial antidote, but it is not yet certain whether alcohol, or resveratrol, or both, are the active ingredients.
Why should chemicals like resveratrol play a role both in the French paradox and in caloric restriction? Dr. Sinclair believes the chemicals are produced by plants in response to stresses like starvation and that browsing animals may have evolved to make use of the chemicals as a signal of hard times ahead. Other scientists said this idea was possible but not particularly plausible.
Most people across the world are quite familiar with resveratrol information due to the various celebrity endorsements and exclusive media coverage. Found in red wine, Japanese Knotweed and red grape skins, this natural phytoalexine has a lot of benefits. Reported benefits include energy levels enhancement, memory improvement and reduction in heart problems, joint problems and cancer. Cell vitality is enhanced by resveratrol due to the presence of the enzyme sirtuins which is a well known antioxidant.
Though it was first found in red wine producing muscadine grape skins, today you can get concentrated resveratrol amounts in resveratrol supplements. Its a well known fact for many years that moderate amounts of red wine are quite beneficial on many counts. Most supplements also have grape seed extracts. Hence, red wine, grape juice and resveratrol supplement intake is the best way to get the benefits of resveratrol.
The potency of various sources is different. Resveratrol supplements which are made from varied natural resources are the best way to get the required amount of resveratrol. Though red wine or grape juice is great for health, the quantity of resveratrol found in them is hardly sufficient to meet your needs as compared to the concentrated supplement form.
If you read about resveratrol, you will be amazed to know the various benefits of resveratrol like neutralizing free radicals, toxins, reducing fat in the blood, enhancing the immune system and the stamina. Its also good for preventing aging, cholesterol level control and making the immune system strong along with weight loss. Resveratrol has millions of benefits and almost all parts of the body and its functions are benefited from this compound.
The antioxidant characteristics also aid in reducing aging and related signs. Being an anti inflammatory, it also aids in reducing and alleviating pains and aches. Besides its also great in enhancing the healthy cell growth and regeneration in teeth, bones, hair and skin.
Resveratrol became an instant hit when it featured on Oprah with Dr. Oz who educated the public about its benefits. Most people started inquiring about resveratrol after they saw 60 minutes and its health advantages. Lab results on animals have indicated that life expectancy can be enhanced by 30% in the animals. However, research for the human benefits is still ongoing. Most researches have concluded that smaller doses are less effective than larger doses.
Laboratory researches indicate that red grape juice or red wine will not give the required amount of resveratrol though this goes against the French paradox. Nevertheless, if you have read the resveratrol information and intend to check on its benefits, then taking supplements is the best and the easiest ways to get the benefits of resveratrol since it is in concentrated form.
Resveratrol supplements are the latest anti-aging fad. Aging means breaking down, but broken things can be fixed. Aging is characterized by a progressive deterioration of physiological functions and metabolic processes.
The healthy reputation of dietary antioxidants just got more support, with one type turning in a spectacular anti-aging performance. Research studies continue to find more interesting benefits from this red wine compound, including potential anti-cancer and anti-aging activity. As to its anti-aging potential, resveratrol activates a cells survival defence enzyme, which prolongs the time cells have to repair their broken DNA.
Newspapers, magazines and TV over the last few years have been filled with news of the anti-aging, antioxidant and seemingly miraculous properties of red wine. Wine lovers are probably already aware that red wine contains a powerful antioxidant: resveratrol. antioxidant Resveratrol appears to work as a powerful antioxidant helping quench free radical damage in the body, but also has a unique mechanism of action that may prove to have significant life extension properties.
Antioxidant resveratrol action is very important for the heart because it can reduce the blood pressure by opening the arteries hence increasing the blood flow through them. Antioxidants slow down cell damage and the progression of degenerative diseases such as heart disease, diabetes, cancer, Alzheimers and Parkinsons. It can also improve the organ, eye, skin, teeth and gum health.
The primary health component of wine that researchers have uncovered is called resveratrol. Resveratrol is also found in a number of other foods and berries, such as peanuts and blueberries but grapes, particularly wine making grapes such as Muscadine, are the clear winner.
Resveratrol maintains cell viability and exerts an anti-oxidative action by enhancing the intracellular free-radical scavenger glutathione. Resveratrol is an active polyphenol found in red wine that has anti cancer effects. Resveratrol is known to fight cancer tumour growth. Resveratrol protects heart tissue from cancer chemotherapy drug. Resveratrol is known to be protective against oxidative cardiovascular disorders.
Red wine contains tannins and resveratrol, substances which could explain the drinks anti-cancer properties. Consumption of red wine is associated with a slight but statistically significant reduction in the development of lung cancer, as reported in the journal Thorax. Red wine has been shown, in some experiments, to be more effective than other alcoholic beverages in decreasing some of the risk factors of coronary heart disease. Many believe that the proven benefits of red wine explain the French Paradox in which the French have lower rates of heart disease yet consume a high fat diet.
Resveratrol contains the powerful red wine antioxidant, resveratrol. It is being heralded by scientists and researchers as an anti-aging miracle drug that can help ward off the effects of age-related diseases such as cancer, heart disease, strokes, obesity, diabetes and Alzheimers.
Resveratrol will help you lose weight, increase your energy levels and make you feel & look great.
Scientists from Scotland and Singapore have unraveled a mystery that has perplexed scientists since red wine was first discovered to have health benefits: how does resveratrol control inflammation? A research pare was published In the Federation of American Societies For Experimental Biology published in 2009 The FASEB Journal, not only explains resveratrols one-two punch on inflammation, but also show how itor a derivativecan be used to treat potentially deadly inflammatory disease, such as appendicitis, peritonitis, and systemic sepsis.
Strong acute inflammatory diseases such as sepsis are very difficult to treat and many die every day due to lack of treatment, said Alirio Melendez, senior lecturer on the faculty of medicine at Glasgow Biomedical Research Centre in Scotland and one of the researchers involved in the work. Moreover, many survivors of sepsis develop a very low quality of life due to the damage that inflammation causes to several internal organs. The ultimate goal of our study was to identify a potential novel therapy to help in the treatment of strong acute inflammatory diseases.
In this study, researchers administered an inflammatory agent to two groups of mice. One group was pretreated with resveratrol and the other group was not. The mice that were not pretreated with resveratrol experienced a strong inflammatory response, simulating disease in humans, while the group pretreated with resveratrol was protected from the inflammation. The scientists then examined the tissues of the mice to determine exactly how resveratrol was able to protect the mice from inflammation. They found that resveratrol used a one-two punch to stop inflammation in the mice by preventing the body from creating two different molecules known to trigger inflammation, sphingosine kinase and phospholipase D. This finding suggests that resveratrol may be harnessable as a treatment for inflammatory diseases and may also lead to entirely new resveratrol-based drugs that are even more effective.
The therapeutic potential of red wine has been bottled up for thousands of years, said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal, and now that scientists have uncorked its secrets, they find that studies of how resveratrol works can lead to new treatments for life-threatening inflammation
Source: Federation of American Societies for Experimental Biology
When you think of a treatment for diabetes, you will probably consider a drug or natural therapy that targets the pancreas to help normalize blood sugar levels. Resveratrol, a phytochemical found in red grapes, has been shown to have a host of health benefits -- including improving diabetes in animal studies. But, it turns out, that's not necessarily because it benefits the pancreas. Instead, scientists have made an unexpected discovery: resveratrol's anti-diabetic properties appear to be mediated through the brain.
That's the conclusion of a study conducted in 2009 by scientists at the University of Texas Southwestern Medical Center in Dallas, Texas, that was published in Endocrinology, a journal of The Endocrine Society. The researchers focused on sirtuins, a class of proteins activated by resveratrol that are thought to underlie many of the potential beneficial effects of calorie restriction, including promoting longevity and slowing down the aging process.
Early studies in mice have produced important evidence showing that when resveratrol activates sirtuins, diabetes is improved. While sirtuins are expressed virtually all over the body, until now researchers have remained in the dark about what tissues could be mediating resveratrol's beneficial effects on the disease.
"We know that sirtuins are expressed in parts of the brain known to govern glucose metabolism, so we hypothesized that the brain could be mediating resveratrol's anti-diabetic actions," said Roberto Coppari, PhD, of the University of Texas Southwestern Medical Center and co-author of the study, in a statement to the media. "To test the hypothesis, we assessed the metabolic consequences of delivering resveratrol directly into the brain of diabetic mice. We found that resveratrol did activate sirtuins in the brain of these mice which resulted in improving their high levels of blood sugar and insulin. These findings may lead to new strategies in the fight against type 2 diabetes."
Dr. Coppari and his research team found that long-term infusion of resveratrol into the brains of diet-induced obese and diabetic mice normalized the animals' hyperglycemia (high blood sugar) and greatly improved the rodents' hyperinsulinemia (excess levels of circulating insulin in the blood). The scientists noted in their research paper that these beneficial effects were independent of changes in the lab animals' body weight, food intake, and circulating levels of leptin (a hormone that helps regulate appetite and metabolism).
Resveratrol -- which is found in red wine, red grapes and grape juice, red carrots and Japanese Knotweed -- has been found to promote health in a remarkable number of ways. In addition to fighting diabetes and preventing heart disease, it can help maintain a healthy weight, keep cholesterol in balance and even support increased longevity.
Everyone is beginning to become concerned about long term health as fast food and high fat diets are creating overweight populations so what can you do about it to increase your life span?
Your body possesses a gene(Nrf2) which fights high fat diets and extends life, the question is how to activate it and one solution offered as a result of a study carries out some 18 months ago is to take Vivix an Anti Aging Supplement with Antioxidant Nutrition that activates the Nrf2 anti-aging gene and fights high fat diets and stressful lives demonstrates the effectiveness of Vivix, an anti-cellular aging tonic.
Dr. Chaney Vivix study and Nrf2
At their August 2009 global conference in St. Louis Missouri Shaklee released some results from one of their key clinical studies on Vivix. This was a randomised, placebo controlled clinical study, the most rigorous kind of clinical study. It was also an independent study performed not by Shaklee, but by scientists at State University of New York at Buffalo.
In short, this was the real deal! In this study, a group of volunteers consumed a 910 calorie breakfast from Burger King. One half of the group took Vivix immediately after breakfast and the other half took a placebo. For the group consuming Vivix a key genetic regulator of longevity called Nrf2 (pronounced Nerf 2) increased dramatically within the first 3 hours after the meal. For the placebo group Nrf2 levels actually declined.
If you are feeling a bit under whelmed at the moment, its probably because this is the kind of study that needs a bit of additional explanation before you can fully appreciate it. Lets start with the breakfast, which I have somewhat jokingly referred to as the breakfast of champions.
You see that Burger King breakfast is loaded with the wrong kinds of fat saturated fat & trans fat. Thats the kind of fat that clogs your arteries. Not only does it clog your arteries, but it also causes your arteries to contract dramatically right after the meal. If those arteries are already clogged from previous high fat meals You guessed it It can trigger a heart attack or stroke.
If youre lucky it could mean a trip to the emergency room. But, the most frequent symptom of heart disease is sudden death often triggered by that fat laden Happy Meal, If youll pardon the mixed metaphor And it isnt just Burger King. Almost any fast food meal will do.
Now that I have your attention, lets talk about the protective effects of antioxidants.
In fact, you may have heard about previous clinical studies showing that supplementation with vitamin E or other antioxidants immediately after the Happy Meal can prevent that narrowing of the arteries and perhaps save you from that trip to the emergency room.
You might be asking What does that have to do with Nrf2 and Vivix? Be patient, Im getting there. You see when we are young; a Happy Meal will trigger an increase in Nrf2 which in turn increases production of our bodys own antioxidant defence mechanisms. Nrf2 also triggers our detoxification pathways so that we can get rid of all of the artificial food additives and preservatives in that Happy Meal.
Nrf2 triggers our immune balance pathways (high fat meals depress the immune system and can also cause inflammatory and auto immune responses). Finally, Nrf2 triggers our anti-stress pathways (high fat meals trigger cortisol production, which can accelerate the aging process) and much, much more.
But when we get older, Nrf2 is no longer triggered by those high fat meals and we lose our natural protective mechanisms. When that happens the aging process, and our risk of heart attack or stroke, is increased by every high fat meal that we consume.
By now you are probably starting to understand why the ability of Vivix to activate the Nrf2 gene is such a big deal. But, I dont want you to think of Vivix as simply an antidote to a bad diet. You see Vivix turns on Nrf2 whether you are consuming a high fat meal or not.
Just think how much more beneficial it will be to keep your natural antioxidant defence mechanisms, your detoxification systems, your immune system, and your anti-stress systems in tip top shape without wasting those resources having to compensate for the effects of a bad diet.
So let me summarize what this study shows:
Vivix activates the Nrf2 gene, which is a master regulator of longevity.
This shows that the dosage of resveratrol and ellagic acid in Vivix is appropriate
That those beneficial polyphenols get into your bloodstream (they are bio available) and that they have their intended anti- aging benefits.
In short the study shows that Vivix works in real people like you & me.
Nrf2, in turn, activates the bodys antioxidant defence mechanisms, detoxification mechanisms, immune balancing mechanisms and anti-stress mechanisms. These are all mechanisms that slow down cellular aging and reduce the risk of degenerative diseases.
Vivix can reduce the damage caused by a high fat diet, but will be even more effective at slowing the aging process if used along with a good diet and a lifestyle that includes weight control and exercise. The study actually shows much more than this, but Shaklee cant release the other data until the manuscript has been accepted for publication. So stay tuned for even more exciting results in the future.
Resveratrol is a chemical compound found in certain plants. It is called a phytoalexin because plants naturally produce it as an antibiotic substance to fight both bacteria and fungi. Plants containing resveratrol include the grapes and skins of grapes that produce wine, raspberries, mulberries, blueberries and cranberries. Resveratrol can also be found in peanuts, certain pine trees and in Japanese Knotweed.
Many believe that resveratrol may have anti-aging properties, which has caused the substance, usually derived from Japanese Knotweed, to be marketed as a nutritional supplement. So far, studies conducted on mice have provided the only evidence for claims that resveratrol may lead to longer life.
One of the initial reasons that resveratrol was considered as potentially beneficial was observation of the French lifestyle. Though the French tend to consume a diet higher in fats than in many other countries, they have an unexpectedly low incidence of heart disease. Many believe that the lower levels of heart disease are due to frequent consumption of red wine. Although it has been shown that red wine has anti-coagulating effects, many feel that resveratrol may also play a role.
It should be stated that the amount of resveratrol in red wine is relatively minimal. Probably the best common food source if one wants to consume resveratrol in its natural state is peanuts. Peanuts have significantly higher resveratrol content than do any berries or grapes that produce the chemical.
Preliminary studies suggest that resveratrol might be an excellent antioxidant, may extend exercise tolerance, and may help reduce memory loss. There is some evidence to support the claim that it may increase the ability to fight retro viruses like HIV and herpes simplex.
Since it is also an anti-aging drug, it has already been marketed as a nutritional supplement. This may be a bit premature since not all negative impacts have been studied. There is some evidence in mice studies to suggest that resveratrol might act like an estrogen in the body and actually contribute to more cases of breast cancer.
However, the nutritional supplement of resveratrol contains tiny amounts, compared to what can be naturally derived from food. Some suggest that when resveratrol is consumed in food, it may actually leave the body much more quickly than the chemical supplement version would. As well, resveratrol supplements are at much lower doses than those used in most mouse studies, so effects might be minimized.
Still resveratrol remains an interesting plant compound that deserves further study. The Food and Drug Administration has registered it as an investigational drug, so it is likely to receive more study. Some evidence certainly exists to suggest that resveratrol may prove of great benefit to humans.
Resveratrol supplements have become easily obtainable in the USA and around the world. Resveratrol is a substance which was first discovered in plants such as Japanese Knotweed. It is created by the plant whenever a plant comes under external attack which might destroy it. Including invasion from bacteria and additionally from fungi that could stunt a plants growth or make it die. Each time a person is looking for a method to assist in cancer treatment,they will find good results with using chemical medications. On the other hand, many medications that people take to treat or avoid cancer can in fact become addictive that will have deadly unwanted side effects. Therefore, large numbers of people are trying to find all-natural treatment options to aid in cancer protection.
Resveratrol restricts and treats cancer becuase:
It is an antioxidant However is not precisely classified as antioxidant, but resveratrol demonstrates a lot more powerful antioxidant-like feature that fights free radicals in the body. The toxins are the reason for many mutation and cell deterioration which could graduate to cancer; at the time you eradicate the toxins, you terminate one root cause of cancer.
As apoptosis inducer When theres something amiss during cell division or even a mutant cell is formulated, the cells are hot wired to kill itself (apoptosis, thats a type of suicide if you may) simply to stop it from developing into cancer. But in some instances, apoptosis wont occur and also formation of cancer is pending. Resveratrol helps stimulate apoptosis.
As cancer cells mitochondria inhibitor Resveratrol acts on mitochondria in cancer cells that obstruct its correct functioning, thus limiting the needed energy for cancer cells to multiply. This course of action also plays a role in the oncoming of apoptosis.
As chemotherapy and radiotherapy help It has additionally been observed that resveratrol can aid one other treatments of cancer for example chemotherapy and radiotherapy by safeguarding the healthy cells in opposition to their unwanted effects.
Resveratrol is often taken by those who are in various stages of cancer. Additionally, they could be taken as a preventative measure, to prevent the oncoming of various varieties of cancer. These supplements have become safe to take and if taken on a daily basis have been proven effective in decreasing the advancement of cancer. These supplements can be found in two distinct forms. You will find basic Resveratrol supplements that are available in pill form or liquid form that can be taken daily. If youre searching for an option to chemical cancer medications you should consider the use of Resveratrol.
Resveratrol truly is known as a miracle substance that has clinically been tested, approved, and proven to decrease a persons probability of acquiring cancer. Moreover, it can be taken to reduce high blood pressure and to prolong an individuals life. This supplement is available in the pill variety as well as in liquid form. It really is reliable enough to consume dally and could even be placed in foods as well as in drinks. It tones up an individuals immunity process and can additionally avoid certain types of cancer from being created within you.
Anti-oxidants are important for body functions as the combat free radicals, which occur naturally as a result of normal biochemical reactions in the body. For example, burning oxygen for energy or for even simple immune system responses generate free radicals. Free-radical-generating substances can also be found in various foods we eat (especially oil fried foods), the drugs and medicines we take, the air we breathe and the water we drink.
As free radicals react with the various cellular structures, they produce cell damage, which accumulates, causing problems and sometimes cell death. Numerous studies have led to the accepted scientific fact that increased production of free radicals causes or accelerates cellular injury and also leads to disease. Free radicals are also one of the fundamental reasons we age. In fact, oxygen can be considered the ultimate paradox of life in that it is absolutely necessary for life but it is also the number one cause of free radical production which ages and ultimately costs us our lives.
Fortunately, although it is impossible to prevent all free radical damage, there is a way to eliminate a significant amount of damage. The answer lies in the simple consumption of antioxidants. Antioxidants, also known as free radical scavengers, are compounds that either reduce the formation of free radicals or react with and neutralize them.
There are numerous antioxidants available for use today in speeding the repair process. Resveratrol vitamin C, cacao, beta carotene, vitamin E, glutathione, acai, grape seed extract and superoxide dismutase are among the most popular, but there are hundreds more anti-oxidants than these sold in the local nutrition store.
Resveratrol is a natural, polyphenol compound that is being proven to have anti-aging, antioxidant, anti-inflammatory, anticancer, anti fungal and anticoagulant properties among many other positive effects.
Today, its nearly impossible to open up a magazine, newspaper or watch a TV health related show and not see a story on resveratrol. The positive effects of resveratrol have been discussed on many popular TV shows after scientists discovered that it may lengthen life due to the fact that it is part of a group of compounds that affect sirtuins which are proteins that control aging.
Resveratrol quickly became the lead story on 60 Minutes and was advocated by Barbara Walters on her talk show. Additionally, resveratrol was featured on Fox News, on The Today Show, and most importantly by Dr. Mehmet Oz on the Oprah Winfrey Show.
Resveratrol has become known as the red wine miracle extract which is interesting since resveratrol is actually produced in a wide variety of plants in response to fighting invading fungus or viruses. Discovered first in 1940 in the roots of a plant called Veratrum Grandiflorum, resveratrol was later identified in grapes (1976) and in wine (1992). There are a great many other plants that contain resveratrol, with the richest source being the Japanese Knotweed plant.
Today, animal and human studies are beginning to accumulate, demonstrating the powerful impact that resveratrol may have on arthritis. Human studies are showing multiple effect pathways leading medical researchers to believe that resveratrol might be the single most important nutrient for controlling arthritis and its negative effects. Similarly powerful results are being obtained by cancer researchers and other medical scientists studying a wide variety of disorders including diabetes, pancreatitis, kidney, and liver disease.
Resveratrol is non-toxic. However, it may interact and lessen the effect of many cardiac drugs such as statins, erectile dysfunction drugs and others. If you are under a doctors care and on daily medication, you should check with your doctor before beginning resveratrol supplements.
The quality of Resveratrol-based supplements is not the same. Many products use only 8%, 20% or 50% purity ingredients. If the label doesnt list the purity, you dont know what youre getting. The best Resveratrol is from polygonum cuspidatim, or Japanese Knotweed, and is at least 98% pure trans-Resveratrol. A water-ethanol only extraction yields low purity. To get to 98%, more expensive extraction processes are required.
Plants, when stressed by parasites, various infections, ultraviolet radiation, or injury, synthesize specialized polyphenol compounds called phytoalexins.
Resveratrol is a potent phytoalexin, was originally identified in 1940 from the white hellebore lily. The most concentrated known natural source is red wine, and the Asian medicinal plant polygonum cuspidatum (Giant Knotweed). Resveratrol, together with other bioactive ingredients in these plants, has been used as a botanical dietary supplement in herbal formulations for thousands of years in traditional Chinese, Japanese, and Indian medicine for their health producing effects.
In the human diet the greatest source of Resveratrol and associated polyphenols comes from the skins of red grapes. Resveratrol acts as the plants antibiotic or fungicide to ward off attacks, particularly from various fungi. During wine making, the Resveratrol is concentrated. The type of grape, climate, and soil are all factors that influence the level of Resveratrol found in red wine. The longer the red grape skin is in contact with the wine and juice, the higher the Resveratrol content. Resveratrol itself is an off-white powder that, chemically, is found in two forms, depending on the structure of the molecule. Trans-Resveratrol is the more active form (as compared to cis-Resveratrol), preferred for use in supplements. It is relatively stable if protected from light, oxygen, and a high pH environment. If exposed to light, it will rapidly convert to the less stable form, and lose much of its biological effect. Dried red grape skins yield approximately 92 mg of resveratrol from 1 kg of grape skins, which is approximately a 10,000:1 ratio.
Resveratrol supplements from polygonum cuspidatum are available commercially in several concentrations. The lower purity 10%, 25%, or 50% extract usually contains large quantities of emodin, which can have unpleasant side effects.
Resveratrol is successful chemical produced by plants to combat diseases that environment throws at them. In short, they choose resveratrol to live longer why do you think Japanese Knotweed is obnoxiously long-living. Among the many known resveratrol positive aspects is being able to help people age gracefully. Resveratrol is known as a polyphenol antioxidant thats been verified technically to have benefits for the human body in preventing and treating, in big enough doses, terminal sicknesses for example, cancer.
History
Although it was first discovered in 1940 in the roots of the white hellebore and soon after from Japanese Knotweed. Scientists worldwide, whether they are from Japan, England, USA etc. have all been researching the properties of how it operates and in what way it could be reproduced to be a part of the medications industry. So powerful are the healing benefits. When certain plants like grapes, mulberries, peanuts etc., produced a substance called resveratrol to protect from pathogen attack, interest was developed to research for this substance whether it could be implemented for human also against pathogen attack. To the extent the studies commendable. Yes, resveratrol is an excellent antibiotic antioxidant.
About Resveratrol
Resveratrol occurs naturally in peanuts, grape juice and red wine and laboratory experiments discovered that mice fed a high fat diet coupled with resveratrol supplements show no sign of fatty livers or insulin resistance, that happens to be a natural for those who have high fat diets. Furthermore, resveratrol has been proven to support higher energy levels in your body. These incredible benefits happen to be named the origin of this French paradox wherein French people drink wine within their each meal. Afterwards, most likely it was discovered that French people are less vulnerable to coronary disease.
Drinking a glass of wine regularly is likewise as taking a .5% of resveratrol dosage. Though this test was only carried out on mice, the supplement could be taken by humans safely. Both concentrated doses and supplemental doses might be great causes of various health advantages. Eating a high fat meal every day can eventually develop levels of cholesterol in your body and decline the health. Resveratrol has been proven to assist improve all-around health even with high fat diet. This can be because of the fact that the benefits provided by resveratrol are exactly like the features about reducing the calories. Resveratrol keeps your sensitive skin along with the heart healthy and stop the operation of aging. This natural antioxidant can be a vital key in delaying growing older and develop a congestion to prevent diseases.
Other resveratrol benefits are said for being protection against cancer. In reality it may have confirmed to be an up and coming new cancer treatment since it is competent to stop cancer in every its stages of growth. There are several advantages of this metabolite but another couple which are good for me and you, besides a good defence from terminal disease, is it is especially beneficial in controlling energy throughout the body rendering it good for anyone who is with diabetes type 2 and in addition it fights aging. So thats best part for anyone.
Even though we all have the urge to stay young, trim and healthy, we have not been able to reverse the aging process. It has not been possible to find a long lasting solution that is effective in controlling the aging process even though we have some times met with success
Red wine has a property to control age in human beings. The compound, resveratrol, is an anti-oxidant that controls freed radicals that corrode our body system. some people dislike consuming red wine regularly because it contains alcohol Now, scientists have been able to isolate resveratrol and provide it as a raw component that may be consumed without any + known contra indications. It has also been shown to have anti-aging properties that are beneficial and do not carry any side effects
Antioxidants help people to keep fit and increase their energy levels. Metabolism releases free radicals, which if controlled, helps us to remain young. The effect is that a person is able to sleep better and it also results in overall health development. The component that is responsible for this is resveratrol and now it is available as a commercially available supplement called Vivix. Vivix Cellular Anti-Aging* Tonic is a revolutionary breakthrough in the fight against cellular aging. Developed after years of research by Shaklee Corporation, the number one natural nutrition company in the U.S., Vivix is the world best anti-aging supplement.
Resveratrol is an ingredient which is found in red wine and several types of foods such as chocolate and Japanese Knotweed. Its benefits have been featured on television shows such as 60 minutes. So if youre not aware of the benefits of Resveratrol which provides us with comprehensive weight loss and skin care heres complete information regarding it.
Resveratrol hasnt grown in popularity overnight like some other products, which boast about their beneficial advantages with persuasive advertising with all due respect. However, Resveratrol has been backed up and testified by big names like Oprah and Barbara Walters. Even Dr. Oz has talked about the benefits of Resveratrol and they all cant be wrong. So all in all what youve got is a product which will eventually lead you to success.
Resveratrol has many benefits such as anti aging and anti cancer capabilities whenever taken as a supplement along your diet. Research has also proved that Resveratrol boosts a significant amount of performance for athletes, and it increases their endurance levels.
According to research, Resveratrol has played a part in being responsible for the so called French paradox. Despite the fact that French people consume an ever increasing quantity of saturated fat in their daily food diets. This includes, about three times more butter than regular users as well as four times the amount of pork other people eat yet their average rate of heart disease is comparatively lower. This may be a cause for the excessive consumption of red wine consumed by the French, which of course, contains Resveratrol.
Researchers at the University of Cornwell have stated that if you supplement your diet by taking Resveratrol, the plaque formation within your brain will tend to reduce. By a reduction of plaques within the human brain, you can lower your chances of been afflicted with the Alzheimers disease.
Apart from the benefits of Resveratrol stated above, there are many more stunning advantages this element provides us human with.
To start with Resveratrol lowers down the risk of heart disease.
Resveratrol decreases cholesterol levels.
Resveratrol quickens up the metabolic rate which helps you reduce your weight faster.
Resveratrol increases your sexual desires.
Resveratrol helps protect you from catching on to the Alzheimers disease.
In Conclusion
Resveratrol is a natural component found in seeds and grapes, therefore drinks such as red wine could be a great source of consuming it. You can also find this substance in peanut butter. All in all, with all of promotions that boast reports about improving your health, Resveratrol is undeniably amongst the best antioxidant supplement available. To utilize all of its benefits, dont forget to add Resveratrol in your daily diet program.
Lately, you may have seen lots of information about inflammation, not just inflammation but silent inflammation. Its been a topic in countless newspaper articles and TV news reports. So whats all the fuss about?
Silent Inflammation is inflammation that you cant feel and whats more, average Americans and Europeans are leading a lifestyle that promotes this inflammation. We breathe polluted air, we dont get enough sun, we stress about bills, the economy, we dont always get enough sleep or exercise and especially we dont always eat what we should. Some of the most critical nutrients are missing completely and its only getting worse. The nations number one killer, heart disease is not related to dietary fat, but to inflammation and oxidation. For these reasons and many others supplementation is an integral part of our lifestyle. With a little help from Dr. Sears and Mark Sisson lets explore a supplement that will help all of us ..
Grapeseed Extract What does it do: Grapeseed extract is a potent supplement derived from grape seeds, I know you wouldnt of thought that from the name, particularly those of red grapes. Inside each whole grape seed are varying amounts of polyphenols, certain types of which are known antioxidants the same antioxidants found in green tea, bark, and some fruits and berries. Polyphenols vary in structure and effectiveness, and different types of grapes contain different types of antioxidants. What youre looking for is the length of the chain in each polyphenol. Antioxidants, as youre probably well aware, fight free radicals, reduce oxidation, and lower Inflammation.
Studies Studies have suggested that polyphenols in Grapeseed extract may reduce oxidation and free radical damage, promoting improved cardiovascular health and reducing the chance of heart failure . Another study shows that, by reducing lipid oxidation and the resultant inflammation of the arteries, polyphenols extracted from grape seeds may be able to reduce the risk of heart disease in patients supplementing with Grapeseed extract. Grapeseed extract may also have cancer-fighting properties: in a lab study, resveratrol, an antioxidant common to grape seeds, was shown to cause isolated cancer cells to induce aposptosis, or cellular suicide. In mice, Grapeseed polyphenols applied topically to dermal wounds promoted accelerated healing, and experiments on rats showed that Grapeseed extract, when given with calcium supplements, increased bone density and structural strength (PDF). And finally, a recent study suggested that Grapeseed extracts antioxidant effects decreased tumours and reduced the malignancy of existing papillomas.
Why You Need It Oxidative stress and free radical damage are some of the more insidious dangers to our health, and Grapeseed extract polyphenols, according to multiple studies, reduce their deleterious effects on our bodies. As more and more information comes out suggesting that one of the biggest killers in these counties, heart disease, isnt caused by dietary fat, but rather by inflammation and oxidation, it becomes clear that a supplement with proven antioxidant and anti-inflammatory properties might be a key player in the fight against cardiovascular disease. Getting enough resveratrol and polyphenols from red wine could be a rather expensive habit. Supplements are more effective cheaper and better for your liver.
Research suggests that drinking the occasional glass of red wine may help men to reduce their risk of developing lung cancer.
Research scientist Chun Chao investigated the relationship between lung cancer risk and beer, red wine, white wine, and liquor consumption in men. Adjustments were made for factors affecting lung cancer risk, such as age, race/ethnicity, education, income, body mass index, history of chronic obstructive pulmonary disease or emphysema, and smoking history.
"An antioxidant component (resveratrol) in red wine may be protective of lung cancer, particularly among smokers," said Chun Chao, Ph.D., a research scientist at Kaiser Permanente Department of Research and Evaluation in Pasadena, California.
Chao analysed data collected through the California Men's Health Study, which linked clinical data from California's health system with self-reported data from 84,170 men aged 45 to 69 years. Researchers obtained demographics and lifestyle data from surveys computed between 2000 and 2003, and identified 210 cases of lung cancer.
The results showed that lung cancer risk dropped by approximately 2% for every glass of red wine a man drunk each month. Results also revealed that drinking red wine dramatically reduced the risk of lung cancer in smokers male smokers who drank one to two glasses of red wine each day were found to be 60% less likely to develop lung cancer than other smokers who did not drink red wine. However, Chao warns that male smokers who drink one to two glasses of red wine each day are still more likely to develop lung cancer than non-smokers.
Consumption of white wine, beer, or liquor, was not found to have a significant effect upon lung cancer risk.
Chao said their findings should not be construed to recommend heavy alcohol consumption.
Because wine is an alcoholic beverage, it has always had a bad reputation and supposedly did not have any health benefits. Things were usually made worse in numerous social implications; but in countries like France, Italy, Spain and the other countries on the Mediterranean wine has been part of their culture for centuries. Wine has become an important part of their cultures and considered almost necessary to have it at every meal.
Then scientists started to closely examine wine to learn how it affected health. The research began on a very small scale and grew from that point. Then the French Paradox was announced. From that point on, the research grew at an amazing rate until almost every country on earth was involved in some form of wine investigation. A team of researchers from Harvard University published a report detailing the eight best things to do to fight or prevent heart disease. But this shocked some people to find wine consumption or alcohol was on the list of how to prevent heart disease. The shocking information the researchers were telling the world was that moderate intake of alcohol does improve cardiovascular health. It must be realized the key to successfully improving cardiac health is the MODERATE CONSUMPTION OF ALCOHOL. You will not help yourself if you have to drink a bottle of wine or a case of beer a day. That type of behaviour will not help you improve your heart health.
The Harvard Researchers did not specify exactly what alcoholic beverages they meant. Other scientific studies that followed defined the most effective alcoholic beverage as red wine. They also pointed out that red wine gives the consumer the greatest benefit. Additional studies made its clear that red wine is the most beneficial and healthy form of alcohol. Cardioprotective properties are considered due mostly to the antioxidants found in the grape skin and seeds of the various red grapes used to produce the red wine. Pinot Noir is considered the best red wine as it usually has the most resveratrol and that is what gives the wine its healthy attribute.
Antioxidants are the major contributors to improving heart health. First, they reduce the levels of bad cholesterol in the body. Second, they build up the high-density lipoprotein or good cholesterol, and lastly, they reduce blood-clotting. Reducing blood clotting has a very positive effect because it lessens the chances of a stroke. Another benefit of a glass of wine with a meal is that it can increase a persons lipids and that is a very good thing.
Red wines benefits go beyond contributing to cardiovascular health. When the research became serious, it was discovered that there were a number of flavonoids in the grape skin and seeds. It took several years from the time resveratrol was first discovered before the research grew to todays intensity. Animal studies with mice found resveratrol improved cardiac function and gene activity related to aging, and it also revealed that low doses of resveratrol can retard certain aspects of the aging process. The research went on to show its effect was stronger on the heart than in the brain and muscles. But it did stop some age-related changes in other tissues in the human body.
Caloric restriction has also brought about an important discovery as resveratrol stimulates the sirtuin gene in much of the same manner as it would if the body was experiencing caloric restriction. But, the tissues do not suffer any loss of nutrition. This retards aging and acts to extend life in a number of life forms. Scientific data from other studies has shown that animals on a diet where the caloric-intake is greatly reduced have also lived longer lives than animals with normal diets.
Here is a short list of how resveratrol works to overcome the deadly diseases:
Fights Cancer
Inhibits the growth of tumours
Promotes formation of nerve cells
Treats Alzheimers Disease and Parkinsons Disease
. Heart Disease
Stroke Risk
Effect of Radiation on the body
Cellular Level dysfunction
Free Radicals & Dangerous Toxins
And it increases
Metabolic Rate for Fat Burning for weight loss
Fights Neuroblastoma Cancer
Fights Prostrate Cancer
In closing, I have to say that red wine has many health benefits, but a person cannot drink enough wine to make them healthy and overcome the major diseases. If a person wants a strong program of health support, they will have to work to learn as much as they can about resveratrol as a supplement and limit their consumption of red wine to a single glass of wine per day.
DISCLAIMER: I am not a Doctor and do not give medical advice; this is a news report and cannot substitute for the advice of a medical professional.
My mission is to educate as many people as I can about Resveratrol. I believe resveratrol supplements are showing amazing promise in the research being conducted in such areas as diabetes, heart disease, cancer, obesity and also the brain.
Red Wine Slows Aging. , heres an excerpt from the Times:
Red wine may be much more potent than was thought in extending human lifespan, researchers say in a new report that is likely to give impetus to the rapidly growing search for longevity drugs.
The study is based on dosing mice with resveratrol, an ingredient of some red wines.
Resveratrols effects in mice have been tested, mostly at doses far higher than the minuscule amounts in red wine. One of the more spectacular results was obtained lin 2008 by Dr. John Auwerx of the Institute of Genetics and Molecular and Cellular Biology in Illkirch, France. He showed that resveratrol could turn plain vanilla, couch-potato mice into champion athletes, making them run twice as far on a treadmill before collapsing.
Another report states that resveratrol may be effective in mice and people in much lower doses than previously thought necessary. In earlier studies, like Dr. Auwerxs of mice on treadmills, the animals were fed such large amounts of resveratrol that to gain equivalent dosages people would have to drink more than 100 bottles of red wine a day.
The Wisconsin scientists used a dose on mice equivalent to just 35 bottles a day. But red wine contains many other resveratrol-like compounds that may also be beneficial. Taking these into account, as well as mices higher metabolic rate, a mere four, five-ounce glasses of wine starts getting close to the amount of resveratrol they found effective
While we love the idea of drinking 100 bottles of red wine a day, its a little impractical. but there are other solutions such as taking a supplement like VIVIX -A Revolutionary Breakthrough in Cellular Anti-Aging
Vivix Cellular Anti-Aging* Tonic is a revolutionary breakthrough in the fight against cellular aging. Developed after years of research by Shaklee Corporation, the number one natural nutrition company in the U.S., Vivix is the world best anti-aging supplement. In laboratory studies, Vivix ingredients have been shown to impact the four key mechanisms of cellular aging.*
A 30 day supply of Vivix delivers the equivalent amount of resveratrol found in 3,000 glasses of red wine, and Vivix ingredients are 10x more powerful in slowing a key mechanism of aging than resveratrol*.
All natural. Patent pending. Clinically tested key ingredients. Exclusive.
Wouldnt it be great if we could eat anything we wanted to and not absorb the saturated fat and cholesterol? Well, let me give you a bit of good news. Resveratrol inhibits the secretion of bile in your intestines . Let me explain why that is such good news. Bile is needed for the absorption of fat and cholesterol. If bile is not being secreted, you are not going to absorb very much of the fat and cholesterol you eat. Isnt that just wonderful! This one action of resveratrol could decrease the cholesterol levels of many people.
Lets say you produce a lot of cholesterol even without eating saturated fat and cholesterol. One theory of how atherosclerotic plaque begins is that LDLs (your bad cholesterol) are oxidized, become toxic, and cause injury to the cells in the wall of the artery. An immune response occurs as a result of the injury and causes a build-up or plaque in the area. Resveratrol has been shown to inhibit LDL oxidation and resulting toxicity in cells
What if you already have plaque build-up in your arteries? A heart attack is often caused by a blood clot traveling in an artery and getting stuck in an area where the atherosclerotic plaque has narrowed it. The interruption of blood flow in the artery is what causes the heart attack. The blood-thinning effects of aspirin is why doctors may advise their patients to take one each day. This is also one of the reasons why fish oil is good for your heart. The omega-3 fatty acids in the fish oil help to thin the blood. Resveratrol from grapes is a winner in this area, too, because it significantly decreases blood clotting activities . In addition to inhibiting blood clotting, resveratrol dilates the blood vessels and increases blood flow. This effect was demonstrated when male patients who already had coronary heart disease were given a red grape extract mixed in water . So, resveratrol has several effects that help to prevent a heart attack.
Rat studies have shown that even when a heart attack is occurring, resveratrol reduces the size of the heart attack and extent of injury and significantly preserves heart function . Let me reiterate this, WHILE a heart attack is occurring, resveratrol is still at work. These studies seem to indicate that if you are at risk for a heart attack, resveratrol could save your life.
How Can Resveratrol Affect Cancer Risk?
Resveratrol from grapes has protected against all three stages of cancer development (initiation, promotion, & progression) in skin cancer in mice . Initiation is when a carcinogen invades your cells, promotion is when something causes the cancer to become active, and progression is when the cancer is growing. The initiation stage may occur years before promotion and progression. Even if you are not in the habit of eating grapes or drinking grape juice or wine at the time a carcinogen invades your body, resveratrol may still be able to inhibit cancer growth if you start eating grapes or drinking grape juice later.
Resveratrol has demonstrated antitumor activities in breast , multiple myeloma, lymphoma , leukemia , prostate , ovarian , uterine , colon , colorectal , and pancreatic cancer cells in a variety of ways. In leukemia cells, resveratrol worked synergistically with chemotherapy and was even able to kill drug-resistant colon cancer cells .
Other Resveratrol benefits
We have already learned about the beneficial effects of resveratrol during a heart attack, but it has many of the same types of benefits for stroke. A study of rats pretreated with resveratrol has shown that this phyto decreases the magnitude of a stroke and prevents motor impairment associated with stroke . If you are at risk for stroke but drink grape juice or eat grapes, your risk of a severe stroke with motor impairment may be reduced.
Resveratrol has suppressive effects of oxidative stress and pro-inflammatory responses associated with several neurodegenerative diseases such as microaglia , Parkinsons disease , Huntingtons disease , and even Alzheimers disease and dementia . This phyto reduces the motor and cognitive impairment of Huntingtons disease in rodents . More so, it improves performance records in behavior tests and cognitive ability in mice with Alzheimers . These studies suggest that resveratrol has therapeutic potential in at least some neurodegenerative diseases.
Resveratrol appears to be of benefit for some inflammatory gastrointestinal problems. Viral-induced gastroenteritis (inflammation of the stomach) is alleviated when mice are supplemented with grape juice . It is also able to reduce the damage caused from chronic colitis and helps to rebuild normal colon cells in rats .
How about reducing complications of diabetes? Diabetes causes oxidative damage to the nervous system which often results diabetic neuropathy (effects nerves and feeling all over the body), but resveratrol significantly reduces this oxidation in rats . It may be a potent neuroprotective agent. Likewise, resveratrol decreases the oxidative stress associated with diabetic nephropathy (abnormal kidney function) . Even in non-diabetic acute kidney failure, it helps to restore kidney function in rats .
These studies are simply a sampling of all the good things in your body that resveratrol may do. It may also be beneficial to help prevent damaging effects of high blood pressure (32) and protect against cataracts (33) and age-related macular degeneration (34).
A few years ago , the USFDA sent letters to several companies asking them to explain their claims about the efficiency of some alternative medicines in fighting cancer and they still monitor the situation.
Though there still doesnt exist a panacea for treating the disease, some promising reports have been published which have raised hopes vis-a-vis the power of naturals in arresting the disease.
How wine helps
Wine, or rather a constituent of the red wine called resveratrol could aid in cancer prevention. The ingredient is actually a part of red grapes from which the red wine is derived.
The researchers at the University of Nebraska Medical Center have found that it works by inhibiting abnormal cell growth. Abnormal cell growth is a prime characteristic of many forms of breast cancers. Consequently, the wines powers could be harnessed to possibly prevent breast cancers.
In fact resveratrol is also sold as a dietary supplement, but its effectiveness in suppressing abnormal cell growth has come to light only recently.
A natural substance to the rescue
Cancers can sometimes be quite problematic to treat, as they can stop responding to cancer drugs, or even become resistant to them. But a natural substance argyrin has been found to destroy the unwanted tumor cells. This discovery has been published in the journal Cancer Cell, and the research was conducted at the Helmholtz Centre for Infection Research.
While, research on naturals has shown promise, an advancement has been registered in conventional medicine as well. For instance a compound called STF-62247 discovered by the Stanford University researchers has been found to selectively damage cancer cells only, rather than target healthy cells too. Since cancer drugs can sometimes harm healthy cell too, this research published in the journal Cancer Cell, is perhaps just the first step towards developing effective cancer therapy with minimal side effects.
So till the time the science of cancer drugs with less side effects is perfected, the promise of naturals in treating cancer is welcome news for sure.
Research carried out by scientists at the Peninsula Medical School in the South West of England found that resveratrol, a compound present naturally in grape skin, can protect against the cellular damage to blood vessels caused by high production of glucose in diabetes, according to a paper published in the science journal Diabetes, Obesity and Metabolism in Sept 2008
The elevated levels of glucose that circulate in the blood of patients with diabetes causes micro- and macrovascular complications by damaging mitochondria, the tiny power plants within cells responsible for generating energy. When they are damaged they can leak electrons and make highly damaging free radicals.
Complications that can result when this happen include nephropathy (kidney disease), heart disease and retinopathy (which if left untreated can lead to blindness).
Resveratrol stops the damage by helping cells make protective enzymes to prevent the leakage of electrons and the production of toxic free radicals.
As well as being naturally present in grape skins, resveratrol is also present in seeds, peanuts and red wine.
Dr. Matt Whiteman, Principal Investigator and Senior Lecturer at the Institute of Biomedical and Clinical Science, Peninsula Medical School, commented: Resveratrols antioxidant effects in the test tube are well documented but our research shows the link between high levels of glucose, its damaging effect on cell structure, and the ability of resveratrol of protect against and mend that damage.
He added: Resveratrol or related compounds could be used to block the damaging effect of glucose which in turn might fight the often life threatening complications that accompany diabetes. It could well be the basis of effective diet-based therapies for the prevention of vascular damage caused by hyperglycemia in the future.
The Peninsula Medical School is a joint entity of the University of Exeter, the University of Plymouth and the NHS in the South West of England, and a partner of the Combined Universities in Cornwall. The Peninsula Medical School has created for itself an excellent national and international reputation for groundbreaking research in the areas of diabetes and obesity, neurological disease, child development and aging, clinical education and health technology assessment.
Source: Andrew Gould
The Peninsula College of Medicine and Dentistry
Its true. Time is a friend to no one. As you get older, you start seeing wrinkles on your face, a loss in libido, and a lack of energy that you may have had earlier in life, and thats depressing for anyone.
Once you hit your mid thirties, you start not looking like the young beauty you once did, and you begin to just give up on yourself and being active.
Often, well look back on the way we were and how we looked, and think about what wed give to have that back.
But who said we have to grow old graciously; why do we have to be older to be wiser?
Studies say that you dont. Resveratrol, a chemical recently introduced, celebrated by many and supported by substantial research, is the fountain of youth for our cells, our bodies and is available now.
Celebrities like Oprah Winfrey and Barbara Walters have espoused the benefits of resveratrol, and news programs around the world are talking about it as if its the next best thing.
Resveratrol is the powerful antioxidant found in red wine which if consumed in moderation is lauded for its benefits to your heart; it also might be the good-health and youthful secret of the French.
Will resveratrol help make you younger? Though still in its early stages, the research is astonishing.
And those who study Resveratrol are confident that the research will confirm the hypothesis; you will look, feel and act younger by using resveratrol.
Below is just one testimonial BACK, SCIATIC, SHOULDER PAIN
I am so excited to share with you what has happened to me since I started on Vivix. I need to give you some history to understand my story. 35 years ago I cracked my tailbone when I fell off a snow tube. I have had trouble with my tailbone off & on ever since. Two years ago I started on my weight loss program & cracked my tailbone again while exercising. This time it affected my sciatic nerve. I was in terrible pain. It hurt from my waist clear down to my toes. The chiropractor also told me that my lower disk was deteriorating. I have never experienced pain that intense! I had a lot of trouble sleeping at night. When I sat I had a shooting pain go down my leg. It would go numb if I sat too long.
During this time I lost 40# with Cinch and I know that helped. I tried to stay as active as possible & used a lot of Shaklee food supplements. Over time it got a little better but I still had trouble sleeping at night.
In April I changed health clubs and tried a new exercise machine. I knew I was in trouble when I started the exercise. I immediately felt a terrible pain in my lower back and my sciatic nerve was "HOT" again! I slowed down on my exercising a little but didn't stop. Nights were the worst. My lower back felt like it was going to break in two. It was very hard to get out of bed. When I finally got out I was very stiff & it took a couple steps to get moving. I looked like an old lady. I started taking Advil to help relieve the pain so I could get some sleep at night.
Then in June I was pulling in the boat anchor & hurt my shoulders. It hurt really deep in my shoulder muscles. I use to sleep on my side with my arm under my pillow. I couldn't sleep on my side due to my sciatic nerve pain & now due to my shoulders. I only got a couple hours of sleep a night due to the pain so the Advil increased. I was very discouraged because I didn't know how much longer I could deal with the pain & lack of sleep. This happened daily until I was introduced to Vivix.
I started on Vivix on 8-9-08. About 2 wks later I noticed that the weights at the health club didn't seem as heavy and I wasn't as tired after my workouts. Then on 9-8-08 I noticed I slept a little better. It continued each night & my pain got a little less. On 9-11-08 I woke up on my side with my arm under my pillow! I could hardly believe it. I finally told my husband what had been happening since Sept. 8th. I didn't want to tell anyone for a week just to make sure this wasn't a fluke. The back breaking pain is gone! My sciatic nerve pain is gone! My shoulder pain is almost gone but I can still sleep on my side. I am sleeping again at night! I would never have believed that this could have happened just by adding Vivix! I haven't had Advil since the 8th. Thank you Shaklee!!! My husband & I both have Vivix on autoship because we don't want to run out. I just ordered another box of Vivix to keep on hand "just in case". This is an incredible product!
Jim has noticed more energy & clarity of thought since he's been on Vivix.
Suzanne Flemming
The resveratrol in grapes has long been heralded for its heart-healthy properties. But the same compound may also help reduce symptoms of osteoarthritis and rheumatoid arthritis, writes Joseph Maroon, MD, in his book The Longevity Factor.
The Latest News
No one is suggesting that resveratrol will ever replace pain pills. But results from several early studies show that the compound could someday have a place in joint care. In fact, in a recent study, researchers found that injections of resveratrol helped soothe inflamed joints in animals. And while its not clear how much dietary resveratrol would be needed to help arthritis, grapes and grape juice have lots of other health-promoting qualities, so adding them to your diet certainly cant hurt.
How It Works
Resveratrol stops inflammation the same way aspirin and nonsteroidal anti-inflammatory drugs do by inhibiting the molecular switch that turns inflammation on and off in the body.
Many doctors in the field are recommending its use over other methods these days. However, there are several pharmaceutical companies working on their methods through FDA trials. If youve been around you know that locating an unbiased Resveratrol review is pretty hard to do. That leaves you wanting more testimonials and additional proof.
Starting with the dawn of time, science has been fighting hard for a supplement to delay the process of aging. Resveratrol antioxidant benefits were first discovered from medical studies which concluded that people from Okinawa and Sardinia have both the largest number of people living to age 100 and some of the lowest numbers in cancer related deaths. In fact Okinawans hardly have a case of cancer to report on. Thus there has been an intense research on the potentiality of pure resveratrol as an anti aging agent. The product, if consumed regularly for some days, can give you an ultimate makeover, both in term of looks as well as feel.
Do you want to know which is the best pure resveratrol? Aside from just how many live into their hundreds, obviously having the ability to avoid cancer is one way of reaching such ripe old ages, yet scientists are still unsure of why this is. Resveratrol is believed to trigger the action of Sirtuin hormone in the body.Okinawans also use pure resveratrol for other medicinal treatments including the treatment of allergic and inflammatory disorders as well as offering lipid atherosclerosis medication and liver ailments to assist in the recovery of Hepatitis B.
In short this supplement improves your overall health, well being and resistance to weakening diseases.
Ever wondered: "What the heck are the best pure resveratrol supplements out there and which deliver the required dosage for the resveratrol pills daily?" Of the many brands featured, some trans resveratrol products were not recommended by reviews whilst others were favored highly. Low concentration pure source naturals resveratrol is found in a number of pure products. Why dont you take a look around the Net for pure resv customer reviews?
You will find that there is a lot of talk about resveratrol on abc. Maybe that was a bad example because you have to weigh the circumstances. Yes, absolutely, it is an all natural substance that is non toxic. The second anti-aging supplement geared towards taking care of your skin.
While the mice that were supplied with resveratrol supplements displayed a potential weight loss consequence, this does not guarantee that the same effect is absolute in humans. This may be the most common way, but this isnt the best idea. Nutritionists believe that with resveratrol included in ones diet, there is a great potential for weight loss. Pure resveratrol supplements are becoming extremely popular and can be found in most retail stores and online. This supplement is concocted from the magic drug pure resveratrol. Words cant describe it properly. In case you are not aware, tripeptinon and resveratrol as its also known is a fungi which grows naturally in many fruit and vegetables to help protect plants from dangerous microbe bacterias.
All this comes as welcome news as America and the west have some of the worst artery related illness statistics due to a staple diet rich in fat and carbs coupled with little exercise. It is my turn to allow something that explains away the problems with wholesale resveratrol so well. All results are attained from 3 years of animal testing and 7 year study observations on communities who consume Resveratrol on a daily basis. Reports however that you can now buy "pure resveratrol over the counter or online to naturally cleanse and scrub your arteries without any exercise is a plus!. Nowadays, people look to anti-aging supplements to help fight back the rigors of growing older, but how do you know what does and doesnt work? So what are the real benefits?
The consensus is, people should be including some form of this compound into their daily lives. The effectiveness of most of these drugs and techniques is limited, but measurable.
We are facing a mis-match in longevity versus durability; so how do you extend the warranty on your frame? Two thirds of all 65 year olds who have ever lived-in the history of mankind-are alive right now. From the AMA News, April 27, indulging in four unhealthy behaviors may age individuals by 12 years: smoking, excess alcohol, poor diet, and inactivity.
Anti-aging and performance drugs: the search for the fountain of youth
There are mainstream examples of treatment for menopause with which we are all familiar such as hormone replacement therapy for postmenopausal women. For both women and men, treatment of adult onset diabetes and thyroid replacement are common and well accepted. What about manopause? The Hormone Replacement Therapy (HRT) for anti-aging offers new frontiers for clinical studies and treatment.
Resveratrol and Sirt Protein Activators
Testosterone
DHEA
Human Growth Hormone
Protandim
SARMs
Cryogenic Preservation of Adult Stem cells
While space doesnt allow for an in depth analysis of all the above, let me share with you what is emerging as the best of practice.
Resveratrol is behind the French Paradox as to why French women dont get fat; they drink organic red wine. Resveratrol activates the Sirtuin 1 Gene thereby improving mitochondrial function. The drug form SRT 501 is being tested in type 2 Diabetes and a cancer trial is planned. The key is activation of Sirtuin. The problem is that the amount of Resveratrol in red wine is small; one would have to consume 2,000 glasses of red wine a day to reach h the size of the dose currently under study in mice. So where do you get some and how do you get enough? Buyers beware, as a food substance there is no FDA control. In an analysis by Consumer Labs in November, 2007, where 13 supplements were analyzed, there were very mixed results as to the claimed concentration of Resveratrol and cost. While studies are short term and no one knows the long-term effects on humans or the correct dose, it is a very exciting area of research so talk to your doctor.
Testosterone is much maligned but an effective performance enhancer in athletes and fairly well studied in older adults but less publicized yet very promising. 20% 0f men age 60 and 70% of men age 70 are hypogonadal. Accompanying the decline in sexual activity is the decline in muscle mass, an increased risk of falls, an increased risk of fracture and an increased risk of depression. Testosterone testing is controversial as total testosterone is different than that, bioavailable . Supplementation thus should be based on laboratory testing as well as clinical scoring; improvement in cognitive, verbal, visual memory, and mood as well as libido. Supplementation may be provided via IM injection, transdermal patches, transdermal gels, and oral routes. Selective Androgen Receptor Modulators (SARMS) is a way to limit unwanted side effects of testosterone. Obviously, discuss the usage with your physician and fully understand the implications on the PSA level, and HDH/LDL ratio but it is the real deal for the aging male
Here are my conclusions. , no drug can prolong your life though this may not be far off (resveratrol). There is promise with hormone replacement therapy for improving quality of life although safer in men. Follow the progress of scientific outcome studies. Mature males should be screened for testosterone levels, women for estrogen levels and all for thyroid and vitamin D. At menopause and manopause, there should be bone mineral density screening to avoid fracture and aggressive intervention if osteopenic. Your exercise training should be a balance of endurance and resistance.
Red wine, in moderation, has long been thought of as healthy for your heart. The alcohol and certain substances in red wine called antioxidants may help prevent heart disease by increasing levels of good cholesterol and protecting against artery damage.
The news about red wine might sound great if you enjoy a glass of red wine with your evening meal, however doctors are wary of encouraging anyone to start drinking alcohol. Thats because too much alcohol can have many harmful effects on your body.
Doctors do agree that something in red wine appears to help your heart, though its unclear just exactly what that something is until now. Researchers have found that antioxidants, such as flavonoids and resveratrol, have promising heart-healthy benefits.
How is red wine heart healthy?
The studies supporting red wine suggest antioxidants in red wine called polyphenols help protect the lining of blood vessels in your heart. These antioxidants come in two main forms: flavonoids and nonflavonoids.
Flavonoids. These antioxidants are found in a variety of foods, including oranges, grape juice, apples, onions, tea and cocoa. Other types of alcohol, such as white wine and beer, contain small amounts, too, but red wine has higher levels.
Nonflavonoids. These antioxidants found in red wine have recently been of particular interest because they appear to help prevent arteries from becoming clogged with fatty blockages. However, these studies mostly involved mice not humans. Resveratrol is the nonflavonoid thats received the most attention from researchers.
Resveratrol in red wine
Resveratrol might be a key ingredient in red wine that helps prevent damage to blood vessels, reduces bad cholesterol and prevents blood clots. The research in mice given resveratrol has indicated that the antioxidant might also help protect them from obesity and diabetes, both of which are strong risk factors for heart disease.
Resveratrol in grapes and other foods
The resveratrol in red wine comes from the skin of grapes used to make wine. The resveratrol in the grape skins are turned into a usable form when the grapes are fermented. That is why resveratrol is found in red wine not white. Simply eating grapes, or drinking grape juice, has been suggested as one way to get resveratrol without drinking alcohol but has been proven as false.
How does alcohol help the heart?
Various studies have shown that moderate amounts of all types of alcohol benefit your heart, not just alcohol found in red wine. Its thought that alcohol:
Raises high-density lipoprotein (HDL) cholesterol, the good cholesterol
Reduces the formation of blood clots
Helps prevent artery damage caused by high levels of low-density lipoprotein (LDL) cholesterol, the bad cholesterol
Red wines potential heart-health benefits look promising. Those who drink moderate amounts of alcohol, including red wine, seem to have a lower risk of heart disease.
Neither the American Heart Association or the National Heart, Lung, and Blood Institute recommend that you start drinking alcohol just to prevent heart disease. Alcohol can be addictive and is associated with other health issues.
Drinking too much increases your risk of high blood pressure, high triglycerides, liver damage, obesity, certain types of cancer, accidents and other problems. In addition, even small amounts of alcohol can cause cardiomyopathy weakened heart muscle causing symptoms of heart failure in some people. If you have heart failure or a weak heart, you should avoid alcohol completely. If you take aspirin daily, you should avoid or limit alcohol, depending on your doctors advice. You also shouldnt drink alcohol if youre pregnant. If you have questions about the benefits and risks of alcohol, talk to your doctor about specific recommendations for you.
Research from the American Journal of Clinical Nutrition indicates that resveratrol has a powerful effect on our metabolism and our ability to effectively lose weight. This is great news for the millions of Americans who are overweight or obese and need help dropping pounds to reduce their risk of heart disease, stroke, diabetes and many types of cancer.
Its important to understand that nutrients can assist with healthy weight loss, but are not a substitute for a well balanced, reduced calorie diet and regular exercise. Nutrients such as Resveratrol work at the cellular level to burn fat by increasing metabolism, preventing new fat cells from forming and reducing body inflammation.
Resveratrol has evolved as a powerful protective mechanism to certain plants, providing them with defenses against natural enemies. Best known as the key ingredient behind the French Paradox, whereby people eating a relatively unhealthy diet are protected against heart disease and cancer, resveratrol has now been shown to inhibit the production of new fat cells.
This works at the genetic level, as resveratrol triggers a special anti-aging gene known as Sirt1. When Sirt1 is positively expressed by eating a healthy reduced calorie diet, a cascade of survival mechanisms kick in which have evolved to keep up alive in lean times. Research demonstrates that resveratrol can mimic the effect of eating a low calorie diet and spring the Sirt1 gene into action, halting new fat cells from forming. Resveratrol is a powerful tool to compliment your healthy dietary lifestyle. Its recommended to supplement with 50 to 100 mg daily.
Healthy weight loss is difficult for 95% of those who have tried in vain, but failed. Eating a well-balanced, reduced calorie diet and physical activity are prerequisites to lose weight, yet many people need something more. New science is providing an answer. Resveratrol may be the trigger to stimulate metabolism and reduce inflammation naturally, leading to permanent weight loss and a new lease on life.
A 2008study shows an antioxidant found in red wine destroys cancer cells from the inside and enhances the effectiveness of radiation and chemotherapy cancer treatments.
Researchers say the antioxidant found in grape skins, known as resveratrol, appears to work by targeting the cancer cells energy source from within and crippling it. When combined with radiation, treatment with resveratrol prior to radiation also induced cell death, an important goal of cancer treatment.
The researchers note that although resveratrol might reduce pancreatic cancers resistance to chemotherapy, the impact of red wine consumption on chemotherapy remains unclear.
Researcher Paul Okunieff, MD, chief of radiation oncology at the University of Rochester Medical Center, says red wine consumption during chemotherapy or radiation treatment has not been well studied, but its not prohibited. Okunieff says if a cancer patient already drinks red wine moderately, most physicians wouldnt tell the patient to give it up. But perhaps a better choice might be to drink as much red or purple grape juice, which also contains resveratrol, as desired.
Antioxidant research is very active and very seductive right now, Okunieff says in a news release. The challenge lies in finding the right concentration and how it works inside the cell. In this case, weve discovered an important part of that equation. Resveratrol seems to have a therapeutic gain by making tumor cells more sensitive to radiation and making normal tissue less sensitive.
In the study, published in Advances in Experimental Medicine and Biology, researchers examined the effects of a 50 microgram/milliliter dose of resveratrol on pancreatic cancer cells alone and in combination with radiation treatment. By comparison, the resveratrol concentration in red wine can be as high as 30 micrograms/milliliter.
The results showed that resveratrol had a variety of potentially valuable anti-cancer effects, including:
* Making the cancer cells more sensitive to chemotherapy by hampering proteins that resist treatment
* Triggering cancer cell death (apoptosis)
* Injuring the cancer cells energy source and decreasing its potential to function
While additional studies are needed, this research indicates that resveratrol has a promising future as part of the treatment for cancer, Okunieff said.
Anti-aging to many of us signifies looking and feeling more youthful, longer! It also indicates elevated energy, dealing with an unhealthy way of life, dropping weight by improving your metabolic process, enhancing your complexion, decreasing your cholesterol, and a lot more.
Many also associate aging with the common conditions and effects of aging such as heart disease, diabetes, cancer, Alzheimers, Parkinsons, low bone density, high blood pressure and more.
Did a person realize that a person have an anti-aging gene in your body? Doctors refer to it as Gene 31 and it CAN be stimulated! But unfortunately for us all, Gene 31 is not very effective in our bodies. The great news is, that Gene 31 is packed full of so many benefits that IF consistently productive in our bodies, it might considerably change our life nearly instantly. We can summarize the main, basic functions of Gene 31 in humans to fixing DNA and controlling certain bad genes. It is these bad genes that can cause the proper functioning of cells to be destroyed, which usually can lead to the beginning of numerous conditions individuals suffer as they age.
Once stimulated, this particular amazing anti-aging gene 31 plays a critical role in fighting numerous of the conditions of getting older. Aside from typical illnesses of growing old, Gene 31 can additionally be effective in decreasing cholesterol, blood pressure, and helping in weight loss!
Scientists have discovered that Resveratrol Vitamins, a effective antioxidant discovered in plants, certain nuts, and in heavy levels in the skins of red grapes will activate Gene 31.
Resveratrol is made naturally by plants to protect against unwanted attacking organisms in the plants cells. Resveratrol Vitamins can additionally assist maintain cells in our entire body safe from free radicals.
Additional recently available studies claim that Resveratrol can improve the performance of the brain and heart, and improve the life-span of the cells in our bodies. Numerous nutritionists and health professionals recommend Resveratrol for individuals with a bad immune system or who are recovering from an illness. Others prescribe it as an anti-inflammatory.
What doctors are mainly focusing on is increasing the human lifespan by activating the bodys natural, genetic defenses against illnesses utilizing Resveratrol Vitamins.
The reality that Resveratrol is found in high concentration in grapes may explain the reality that French people usually have a fattier diet than Americans, yet they have less health issues than Americans. Especially, the number of heart attacks among Europeans in general in contrast to Americans is staggeringly lower.
This particular interesting finding is why people say red wine is good for your heart. As the 60 Minutes program reported in January 2009, scientists believe that the Resveratrol in red wine may do actually much more than just maintain the heart healthy. In high concentrations they really feel it could significantly extend life by preventing a number of age related illnesses.
Lab studies discovered that a 150 lb person would have to take in 750 1,000 bottles of red wine every day to get enough Resveratrol necessary to accomplish the results these studies are looking for. Luckily, these days, you can get the effects of massive quantities of red wine in one easy daily dose of Resveratrol Vitamins
According to studies carried out at the Laboratories of Retinal Cell Biology,* and Corneal Cell Biology,{ddagger} and the Department of Ophthalmology,{dagger} Keio University School of Medicine, Tokyo; the Department of Ophthalmology,§ Hokkaido University Graduate School of Medicine, Sapporo; and the Department of Molecular Genetics,¶ Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
Light damage to the retina accelerates retinal degeneration in human diseases and rodent models. Recently, the polyphenolic phytoalexin resveratrol has been shown to exert various bioactivities in addition to its classical antioxidant property. In the present study, we investigated the effect of resveratrol on light-induced retinal degeneration together with its underlying molecular mechanisms. BALB/c mice with light exposure (5000-lux white light for 3 hours) were orally pretreated with resveratrol at a dose of 50 mg/kg for 5 days. Retinal damage was evaluated by TdT-mediated dUTP nick-end labeling, outer nuclear layer morphometry, and electroretinography. Administration of resveratrol to mice with light exposure led to a significant suppression of light-induced pathological parameters, including TdT-mediated dUTP nick-end labeling-positive retinal cells, outer nuclear layer thinning, and electroretinography changes.
To clarify the underlying molecular mechanisms, the nuclear translocation of activator protein1 subunit c-fos was evaluated by enzyme-linked immunosorbent assay, and the retinal activity of sirtuin 1 was measured by deacetylase fluorometric assay. Retinal activator protein-1 activation, up-regulated following light exposure, was significantly reduced by application of resveratrol. In parallel, retinal sirtuin 1 activity, reduced in animals with light damage, was significantly augmented by resveratrol treatment. Our data suggest the potential use of resveratrol as a therapeutic agent to prevent retinal degeneration related to light damage.
Most People are very busy and have not time to take care of their health. This unhealthy lifestyles has had some serious effects on people. Many people have health issues like high BP and cholesterol This has also had an effect on their physical appearance, due to quick aging. Nobody wants this to happen. Thats why they resort to taking all sorts of un prescribed anti aging creams which later leads to some serious side effects. This can be avoided by consuming natural supplements such as resveratrol grape juice. These supplements are made from red or purple grapes and are really beneficial for the body.
Red or purple grape products prevents heart problems by soothing the blood vessels permitting free flow of blood. This is the effect of antioxidants found in the skin and seeds of grapes .Especially purple grapes. The most important antioxidant know as resveratrol is found in the seeds and skin of grapes, these help in stimulating your cells and are as effective as red wine.
Having red wine or resveratrol grape juice maintains your good cholesterol (HD) because it contains antioxidant such as flavonoids. Tests conducted recently by researchers concluded that the skin and seeds of grapes gives a lot of to the heart such as:
Maintaining a Healthy blood pressure
Protects the blood vessels
It helps in thinning of blood
Helps in maintaining low-density lipoprotein (LD), or bad cholesterol
These results on resveratrol grape juice extract are good news for Individual who want the cardiovascular benefits of red wine. Resveratrol Grape juice can also be drunk in the form of supplements which contain prescribed amounts of resveratrol which is useful for date to date activities. These supplements are also available in the form of pills.
It has been proven clinically by Research centers that when resveratrol grape juice is consumed as a supplement, its potency increases. This is because of the combination of many vital nutrients like Vitamin C and E along with other minerals like Calcium and Phosphorus. These healthy supplements offer some good health profits.
Some of the Profits of Resveratrol Supplements are:
Prevents Diabetes
Provides energy boost and helps the manage calories
Prevents wrinkles
Out of the different resveratrol supplements the resveratrol grape juice is an amazing supplement that offers good amount of resveratrol to your body. This helps in maintaining a refreshing experience throughout the day. However these supplements do have some side effects if consumed in excessive quantities. E.g.; It has some side effects on Women who are sensitive to estrogen and who consumes resveratrol grape juice without consulting a doctor.
Resveratrol grape juice is not recommended for children, pregnant women and nursing mothers. It can affect children with growth problem. Also due to the blood thinning properties of resveratrol, people taking anti-coagulant drugs (such as Coumadin or Plavix) should not use resveratrol grape juice without consulting a physician.
Resveratrol is a class of polyphenolic compounds called stilbenes. The compound is naturally created by vines, Japanese Knotweed, pine trees, and other plants to fight against stress, injury and fungal injection. Resveratrol is also found in food sources such as grapes, blueberries, peanuts and cranberries. Red wine contains Resveratrol Supplements and has many health benefits in moderation.
Many years ago scientists dissected the components of red wine to see why it had certain health benefits. Unfortunately the Resveratrol supplement was tossed to the side as a toxicant. Scientist still didnt understand what made French people so healthy. This is when the phrase The French Paradox was coined. The French people smoked, drank wine, ate fatty foods and still had a much lower rate of heart disease, cardiovascular disease, and obesity than the U.S.
In the early 90s scientists discovered that red grape skin contained the Resveratrol supplement and could be the answer to the French Paradox. Resveratrol Supplements have many health benefits and could add additional years to your life. Studies have shown that Resveratrol helps prevent damage to blood vessels, reduces bad cholesterol, slows down aging, reduces inflammation, fights off free radicals and helps cardiovascular health.
When this discovery was made many product manufactures jumped at the opportunity to manufacturer their own Resveratrol Supplements. The problem is not all Resveratrol supplements are created equal. The extraction process must be performed properly to insure the Resveratrol Supplements are pure enough to produce results. Resveratrol is vulnerable to light and oxygen and should be stored away from the sun light in a cool and dry location to protect its potency.
This Anti Aging Miracle known as Resveratrol has been featured on Oprah with Dr. OZ, 60 Minutes, MSNBC, Fox News, and CBS and other programs. This could very well be the answer to living longer, healthier lives.
Red wine is being touted as a health drink nowadays. Aside from being a great drink with your favorite meats, be that beef, chicken or even fish, researchers and scientists are now finding new and amazing things about red wine which has been around for thousands of years.
The compound, naturally present in red wine and grapes, that has been grabbing headlines lately is Resveratrol. Resveratrol has been subjected to a lot of studies lately. One study being done with animal subjects, specifically that of middle-aged lab mice, has seen Resveratrol influencing the genes responsible for aging. These genes are responsible for the rate of cells growing old. These preliminary findings are encouraging for it appears that the aging process had been slowed for these animal subjects.
The same study also found that Resveratrol seems to protect the cardiac muscles. In addition, the compound, in lower doses, induced a calorie-restricting effect on the lab mice.
For Us Humans:
We would have to drink at least 200-300 glasses of red wine a day to achieve the same effect that impacted the lab mice, which is not practical and very unhealthy especially for people who are on an alcohol restricted diet or are forbidden to drink alcohol due to their age, or other considerations.
There is great news for us who want to get great health benefits, like weight loss and younger skin, from red wine without the alcohol. The compound Resveratrol, naturally-occurring in red wine, is now readily available in concentrated form.
As with all supplements, taking this is not and never a substitute, but a supplement for leading a healthy lifestyle, which is reducing or eliminating risk factors for serious diseases like eating food heavy with saturated fat, tobacco use, lack of exercise and excessive alcohol consumption.
Daily intakes of resveratrol a compound from red wine may improve the metabolic profile of people with obesity, according to a new study from Denmark.
Writing in the International Journal of Obesity, researchers from Aarhus University report that resveratrol changed the production of certain compounds called adipokines from human fat cells, and produced an anti-inflammatory effect.
The study is reported to be the first to in vitro suggest resveratrol has anti-inflammatory effects on adipokine expression and secretion in human fat tissue.
Small interfering molecules such as resveratrol are in this matter hypothesized to possess beneficial effects and might improve the metabolic profile in human obesity, wrote the researchers, before adding that the results need to be replicated in vivo.
Resveratrols rosy potential
Resveratrol, a powerful polyphenol and anti-fungal chemical, is often touted as the bioactive compound in grapes and red wine, and has particularly been associated with the so-called 'French Paradox'. The phrase, coined in 1992 by Dr Serge Renaud from Bordeaux University, describes the low incidence of heart disease and obesity among the French, despite their relatively high-fat diet and levels of wine consumption.
Interest in resveratrol exploded in 2003 when research from David Sinclair and his team from Harvard reported that resveratrol was able to increase the lifespan of yeast cells. The research, published in Nature, was greeted with international media fanfare and ignited flames of hope for an anti-aging pill.
According to Sinclairs findings, resveratrol could activate a gene called sirtuin1 (Sirt1 the yeast equivalent was Sir2), which is also activated during calorie restriction in various species, including monkeys.
Since then studies in nematode worms, fruit flies, fish, and mice have linked resveratrol to longer lives. Other studies with only resveratrol have reported anti-cancer effects, anti-inflammatory effects, cardiovascular benefits, anti-diabetes potential, energy endurance enhancement, and protection against Alzheimers.
Metabolic syndrome
The new study sought to investigate if resveratrols anti-inflammatory benefits extended to the low-grade inflammatory state associated with obesity. This is characterized by abnormal levels of circulating proinflammatory factors and an abnormal production of bioactive factors/adipcytokines from the adipose tissue, explained the researchers, and these adipocytokines are suggested to have direct implications for the development of the metabolic syndrome.
Led by Jen Olholm from the Department of Endocrinology at Aarhus University Hospital, the researchers examined the effects of resveratrol (Cayman Chemical) on levels of adipcytokines particularly interleukin 1beta (IL-1B) in human adipose tissue explants.
When human fat cells were exposed to IL-1B, the researchers noted increases in the secretion of pro-inflammatory compounds, including IL6, IL8, MCP-1. However, when the cells were simultaneously exposed to resveratrol, a 16 to 36 percent reduction in the expression of these cytokines was observed.
From human cell to human being
Our results show that the compound ameliorates the proinflammatory response in human adipose tissue and increases adiponectin expression changes, which is hypothetically beneficial, as adipose tissue from obese individuals with metabolic syndrome, expresses lower adiponectin levels and higher levels of proinflammatory adipokines, wrote the researchers.
We are aware that it is difficult to compare in vitro incubations and in vivo conditions, and especially it is difficult to know whether the concentrations used in our study are a meaningful in a clinical setting.
It is known that orally administrated resveratrol is rapidly absorbed and then quickly metabolized, but the local concentration of resveratrol in different tissue compartments are unknown and it is also not known if glucuronidated resveratrol can be locally de-glucuronidated and thus reach a higher local concentration.
However, the concentration used in our in vitro experiments (50 mM) is similar to most other reports on resveratrol effects in different cell types, they added.
Source: International Journal of Obesity
Volume 34, Pages 1546-1553; doi:10.1038/ijo.2010.98
Anti-inflammatory effect of resveratrol on adipokine expression and secretion in human adipose tissue explants
Authors: J. Olholm, S.K. Paulsen, K.B. Cullberg, B. Richelsen, S.B. Pedersen
When you buy your favorite resveratrol supplement, or any different Resveratrol supplement actually, you need to consider whether you are serious about extending your life span as Resveratrol alone wont extend the years.
Clinical tests are tough to prove when it comes to longevity explaining why only animal testing has been carried out on this suspected anti-aging anti-oxidant. Three years of study was carried out on mice, where briefly mice that were fed resveratrol daily were reported to live an extra 26% 32% longer than mice without a resveratrol medication.
Resveratrol also demonstrated in these trials the ability to copy the results of calorie limitation and indoctrinate the activation of the life-extending enzyme offering the body the power to shield your system from oxidative cell damage which is vital if you need to lengthen your life span.
In Okinawa, this is home to the biggest male centenarian population, and here resveratrol is consumed via their staple root vegetable Knotweed which is a part of most local recipes in Okinawa. Unfortunately, it is very tough to get your hands on natural organic Knotweed as most is imported which involves freezing and preserving techniques which damage its overall nutrition.
This is why if you are looking to buy Resveratrol supplements, you may observe that their ingredients contain French full wine grape and giant Knotweed root and rhizome extracts, but with a higher concentration than both these communities will consume each day.
Doctors advise that taking 20mg to 50mg a day is enough for Resveratrol supplements to potentially pack a punch and deliver longevity benefits. This is still up for debate, additionally it depends on how much you weigh and overall health, so buy resveratrol with this in mind...
There continues to be lot of focus on resveratrol and its apparent health benefits and given some well watched television coverage, an increased demand for it but do we understand what the substance really is and why there is such a fuss?
Resveratrol is a substance produced by some plants when they are threatened by infection from a fungus or bacteria. It is anti-microbial, which helps to fight infection by acting as a toxin to the attacking bacterial or fungal cells. Resveratrol exists in two forms, the cis type and the trans type, the trans type being the one which shows great promise as a health supplement.
There are many different sources of resveratrol, it is present in the red wine grapes and the wine made from them, it is present also in peanuts, blueberries, chocolate, Japanese Knotweed and a variety of other foods. Its presence in red wine varies a lot with the grape variety and where it was grown. It is thought by some to be the reason for the French Paradox , the seeming ability of Mediterranean people to consume diets high in fat without suffering the ill effects.
Experiments on laboratory animals have shown several health benefits. In a famous experiment, mice given a high fat diet and resveratrol supplements had a much lower risk of death than those given the high fat diet without the resveratrol. The mice were found to have approximately normal levels of insulin and blood glucose though their cholesterol levels were high. Interestingly the anti-aging effects seen in mice appear to have been mainly in older mice rather than in mice given resveratrol supplements from an earlier age.
Life extending properties were also shown when an Italian team of scientists conducting experiments on fish found that resveratrol could extend their life span considerably. This was the first demonstration in such a vertebrate, other tests to that point having been on fruit flies and worms.
Resveratrol shows anti-cancer properties too for some forms of cancer. Experiments on lab mice show success with skin cancers and test tube experiments show resveratrol fights other cancers such as colon and breast cancer.
A challenge for scientists is working out a reliable method of getting the right dose of resveratrol actively fighting cancer effectively. This challenge arises because resveratrol needs to be preserved for long enough in the body to reach the bloodstream without being broken down. One promising looking delivery method is taking resveratrol in a form which allows it to be absorbed from the mouth directly into the bloodstream. Various methods of delivery are now under investigation from mouthwashes to lozenges and even gum..
Scientific studies have shown several health benefits, as well as several weight loss benefits, linked to the consumption of resveratrol. Resveratrol, commonly found in red grapes, red wines, blueberries, Cocoa, and peanuts, is known scientifically as a phytoalexin. Phytoalexins are a plants defense against negative external stimulus, be it an invading insect, fungus, or other toxin. Resveratrol is made up of extremely concentrated levels of antioxidants, giving the resveratrol weight loss benefits while simultaneously acting to boost the immune system.
Resveratrol Weight Loss Benefits
Regulate blood sugar, insulin, and glucose levels
Increase Metabolism
Naturally Boost Testosterone To Promote Lean Muscle Mass
Resveratrol Health Benefits
High Antioxidant Levels Protect Overall Immune System
Protects Brain From Neurodegeneration Disorders Such As Alzheimers Disease
Helps Prevent Heart And Kidney Diseases
Resveratrol is an amazing supplement, providing several health and weight loss benefits.
If resveratrol is so good for you just where can can you find it, below is a list of the main sources
Red Wine - For years, weve heard about all the wonderful health benefits of drinking wine, specifically red wine, but only recently have we been able to attribute these benefits to Resveratrol. The average glass of red wine contains between 750 micrograms and 1 milligram of active Resveratrol. Red Wine is a great source for Resveratrol since it is the most abundant liquid source currently available. When a person drinks a glass of red wine, they usually consume it over many smaller sips. Since Resveratrol is best absorbed through the lining of the mouth, these smaller sips allow for faster absorption into the bloodstream. Studies suggest consuming two 4-6oz glasses of Red Wine per day to support healthy cholesterol levels, decrease the risk of heart attacks, lower the risk of heart disease and even possibly protect the body from certain forms of cancer.
Japanese Knotweed - This is the most popular source used in Resveratrol supplements and the best source for standardized Trans-Resveratrol. The Japanese Knotweed is actually an invasive weed that is practically impossible to kill. It is native to China, Japan and Korea, and has now made its way to the United States and Europe. It is considered an invasive plant species and can be found in over 39 states and in 6 provinces in Canada. Researchers are currently trying to the determine the relation between Resveratrol and the Japanese Knotweed. invincible nature. Known as Fallopia japonica, Polygonum cuspidatum, and Reynoutria japonica, the Japanese Knotweed can be made into a tea, or even chewed on (tastes like rhubarb) and is available in powder form with Trans-Resveratrol standardization of 10%, 25%, 50%, 98, 99%.
Peanuts - Since many people suffer from Peanut allergies, this is a source that is rarely discussed. Resveratrol can be found in Peanuts, and products that use Peanuts (Peanut Butter, Boiled Peanuts, Peanut Spreads). One cup of Peanuts contains a fraction of Resveratrol compared to Red Wine (approximately 25 micrograms - 50 micrograms) and Peanut Butter contains approximately half the Resveratrol of Peanuts alone. While they are not the best source of Resveratrol, Peanuts are a great source of health fatty acids (Omega-3s), and recent research has shown that consuming one and a half ounces of Peanuts (approximately 45 peanuts) fives days per week can even help to lower the risk of heart disease as much as 50%.
Chocolate - This is one that 99% of people will be glad to see on this list. Researchers have tested a variety of different chocolate products, including: cocoa powders, baking chocolates, dark chocolates, semi-sweet baking chips, milk chocolates and chocolate syrups to determine the presence and quantity of Resveratrol in each. Gram for gram, cocoa powder had the highest average amount of Resveratrol, followed by baking chocolates, dark chocolates, semi-sweet chips, milk chocolate and lastly, our favorite chocolate syrup. The study found that cocoa powder, baking chocolate and dark chocolate contained on average 14 micrograms to 19 micrograms of resveratrol per serving.
Blueberries / Cranberries Blueberries and cranberries contain about 10% of the Resveratrol of grapes. The total amount of resveratrol contained in each varies greatly by region, climate, and variety of berry. Since the Resveratrol content of these berries is so low, theyre rarely used as a source for Resveratrol supplementation. They are however a great source for many other antioxidants and phytonutrients and provide a wide array of benefits.
Supplements In recent years, Resveratrol Supplements have been taking the world by storm. In order to replicate the benefits of Resveratrol shown in clinical studies (usually done on mice), a human must consume far more Resveratrol per day than what can be attained from normal eating alone. It was this gap in dosages that has lead to the increase in Resveratrol Supplements as the primary means to ingest Resveratrol. With so many Resveratrol products currently available, it can be very difficult to decide which products are the best.
Numerous studies have found a link between drinking alcohol in moderation and living a longer life. The common interpretation is that the drink itself is behind the results, that either a balanced amount of alcohol or the polyphenols found in red wine provide health benefits.
But a new study asks whether its the drinks or the persons medical history thats responsible. A team at the University of Texas found that past behavior versus current lifestyle decisions may help explain why moderate drinking is so beneficial later in life, compared to abstention or heavy drinking.
In research slated to be published in the November 2010 issue of Alcoholism: Clinical & Experimental Research, lead researcher Dr. Charles Holahan of the University of Texas at Austin and colleagues looked at outpatient data from 1,142 men and 682 women, aged 55 to 65 years, and followed them for 20 years, recording causes of death and other data. At the end they found that, compared to moderate drinkers, patients who abstained from alcohol had more than double the estimated mortality risk, while heavy drinkers and light drinkers had a 70 percent and a 23 percent higher mortality risk, respectively.
A large portion of the subjects who abstain from drinking admitted to prior problems with alcohol and/or poorer health habits. Lifetime moderate drinkers, they found, use alcohol less as a coping agent and more as a social lubricant. They also tend to exercise more often and had lower rates of obesity.
Our findings are consistent with an interpretation that an important part of the survival effect for moderate drinking among older adults is explained by confounding factors associated with alcohol abstention, they say in the text. Alcohol consumption of one or two drinks per day does not appear to increase the risk of cognitive impairment or decline in older adults.
But what of studies that find wine drinkers enjoy an extra benefit, presumably because of antioxidant compounds such as polyphenols found in red wine? The theory that polyphenols provide wines benefits has led to a growing supplement industry, with shops selling resveratrol and other polyphenols in pill form.
A recent Dutch study looked at the chemical components found in grapes and found little to support claims that polyphenols such as resveratrol provide cardiovascular benefits when acting alone. Grapes and wine contain high amounts of polyphenols, but the effects of these have hardly been investigated in isolation, write the researchers from Unilever Research and Development in the August issue of the Journal of Nutrition.
The research team examined 35 healthy males. The men ate low-fat diets and some took daily doses of capsules containing 800 mg of grape polyphenols. The others took a placebo.
Looking at blood flow, an indicator of heart health and overall longevity, the team found that the cardiovascular health of the men did not improve with either the antioxidant capsules or the substitute pills. The scientists write that the polyphenol treatment had no major impact on blood flow.
But they expressed doubt over whether their findings relate to wine drinking. Please keep in mind that we tested only the effect of grape polyphenols provided as supplements, says lead author Linda A. J. van Mierlo. Wine also contains other substances, such as alcohol.
It may be that the sum of components in wine is stronger than any part. But further research is needed on whether the answer is wine or lifestyle.
Almost 70 percent of Americans have some sort of heart disease but that doesnt mean surgery should be your first response.
It might surprise you to learn that nearly 85 percent of coronary bypass surgeries are done unnecessarily, says THB panel expert Dr. Al Sears. Thats why Im always on the look out for credible and actionable alternative heart information.
And you can learn about a major credible and actionable alternative right now. Small lifestyle changes can help you beat the odds and enjoy better heart health.
Antioxidants are your first step to protecting or even restoring your heart health. Leading doctors are proclaiming the power of antioxidants and there are dozens of studies that prove they promote good heart health. One landmark study even shows that a specific antioxidant may reverse one of the most lethal forms of heart disease.
What Are Antioxidants?
Antioxidants are powerful tools that fight heart disease. But to understand why you need them, you have to understand what oxidation means. It is a natural process which occurs during normal cell function.
Cells are damaged during oxidation and turn into free radicals. That starts a chain reaction which harms more cells and ends in disease. Those free radicals can lead to heart disease. Antioxidants fight free radicals.
Studies prove antioxidants neutralize free radicals, says Dr. A. J. Matthews. He specializes in damage caused by oxidation and runs a surgery in California.
Oxidation produces free radicals. These are unstable molecules that bind to healthy cells, says Dr Al Sears. This damages their delicate machinery, even killing them. He notes that our bodies make our own antioxidants and also consume external antioxidants. This is how our bodies protect us from free radical damage.
However, we produce fewer antioxidants as we age. This speeds cell death and facilitates aging, says Dr. Sears. Thats why its so important to consume the antioxidants we need. Resveratrol is a plant enzyme. Studies show that it thins blood, which reduces the risk of heart attack. Research also shows that it is an anti-inflammatory.
A British study revealed its second powerful heart benefit. Resveratrol possesses anti-inflammatory properties, confirms study author Dr. Mark Birrell.
Dr. Birrell is a lead researcher at Imperial College, London. He says that resveratrol will lead to new therapies for the treatment of chronic inflammation.
Inflammation is becoming a hot topic with visionary doctors who believe treating it may help us defeat heart disease.
Inflammation is not a fancy medical term, says Dr. Dwight Lundell. It is just as you think swelling, redness, and pain produced as a reaction to injury.
Dr. Lundell has performed over 5,000 heart surgeries. He became convinced of one thing during his 25 years as a cardiac surgeon: inflammation is the cause of heart disease.
There was more to inflammation than suspected. It wasnt just a side effect. It was the culprit; the cause of cardiac arrest.
The good news, according to Dr. Lundell, is that inflammation is easily treated without medication.
Treating inflammation is all about simple lifestyle changes and eating the right foods to cool the fire. Studies show that resveratrol will help you do just that. And the best part is that its easy to find. Resveratrol is naturally abundant in grapes, berries, chocolate and Japanese Knotweed..
Resveratrol Product
A revolutionary product called Vivix has been introduced and this brand is once again at the forefront of scientific research. Shaklee Independent Distributors represent scientists who have designed a way to create a unique blend of ingredients to fight cellular aging.
What sets Vivix apart is the unique blends of ingredients and the science behind those formulations. With this new tonic, scientists took the formidable research on resveratrol to a whole new level.
By combining key ingredients with resveratrol, this tonic can impact all four of the mechanisms of aging that occur at the cellular level. No other company or brand has a product like this.
Lets look at how the tonic affects these mechanisms of cellular aging:
Protects and repairs cellular DNA
Positively impacts genetic regulators which help fight cellular aging
Promotes mitochondrial biogenesis, which helps increase the power production within the cells
Reduces the formation of AGE proteins that can gradually clog up your cells
While specific scientific detail may be hard for many of us to understand, that is why we have always enjoyed the benefit of having a team of highly qualified scientists behind this brand. This has resulted in more than 50 years of uniquely effective products based on solid science and research. We continue to use these products because they work!
To learn more and get the breakdown of the science behind this anti-aging tonic, Click here. There is an MD Resource box there for medical professionals as well.
The release of this new tonic is truly a revolutionary breakthrough because it harnesses the power of a unique polyphenol blend to impact the aging process. The special blend of ingredients promote cellular longevity, increase cellular energy, fight free radicals, and promote good health and well being. In addition, the ingredients support heart health, brain health, cardiovascular function, joint health and enhance immunity.
Resveratrol has long been considered a powerful bioflavonoid due to its strong antioxidant potential. It is derived from the skin of red grapes often used for wine, and is the reason that red wine shows such positive health benefits, including blood pressure lowering effects, anti-carcinogenic activity, and benefits to heart and brain health. But in recent years, the benefits of resveratrol have been shown to be even more impressive. In study, this nutrient has been shown to activate a gene known as the siRT1 enzyme, an enzyme that is otherwise activated by a calorie-restricted diet (we have known for years that lab animals and people who consistently restrict their caloric intake live longer). In short, this enzyme has been associated with an increase in an ability to survive physical adversity and an increase in longevity. Furthermore, when the siRT1 enzyme is activated, you are less likely to have adverse wear and tear events so that the years you live remain high quality.
It is believed that resveratrol and its activation of siRT1 results in the stimulation and production of cellular mitochondria. Mitochondria are considered the powerhouses of our cells; they are responsible for the production of energy needed to fuel our bodies. This increase in the production of cellular energy results in a boosted metabolic rate, one typically associated with younger age.
Another possible benefit (if the living longer part doesnt appeal to you!) includes weight control: scientists noted that in mice, resveratrol inhibited pre-fat cells from increasing and prevented them from converting into mature fat cells. Resveratrol also reduced the production of certain messengers in the body called cytokines. These messengers are related to the development of obesity-related disorders such as diabetes and clogged coronary arteries. In addition, the reduction of these cytokines decreases inflammation and might prove through future study to be useful in the control of joint pain and other inflammatory disease. Due to the activation of siRT1, it is probable that resveratrol can also result in increased endurance, prevention of heart disease, and possibly also prevention of Alzheimers, diabetes, and cancer.
The activation of a longevity gene seems to be something out of the pages of a science fiction book, but it seems that we just might be on the right path. We are sure to see positive and negative studies at this point, and we will likely learn more about proper isolation, dosing, and bioavailability. Pharmaceutical companies are actively working to develop a patented form of resveratrol, but the trans-isomer (the active version most often studied at this point) is readily available, and it is questionable whether the pharmaceutical version will truly have any benefit over the naturally isolated form.
Want to get all of the benefits of resveratrol through your red wine? Good luck: to get the 125-250 mg per day that has shown these amazing benefits, you would have to drink around 200 glasses per day (I am not recommending this!). At some point, Resveratrol will find its way into our high quality multiple vitamins so that individual supplementation wont be necessary, but it is not in most of them yet, so it requires some supplementation. Have your integrative physician suggest a locally available version. Make sure that you find a standardized extract of the trans-isomer, a form shown to be more active and the one that is the most researched. Resveratrol has been shown to be clinically safe even at very high doses although these doses arent necessary. There have been some clinical side effects reported including nausea and malaise. As with all supplementation, I believe it is best to talk with your general practitioner or integrative physician prior to beginning anything new, but with the incredible research being produced on resveratrol, this is worth consideration by you and your doctor.
At the end of the day, if we do find that benefits have been over-touted, we will simply have been, in effect, supplementing a very high quality antioxidant (with additional benefits that I did not even delve into here!). An easy addition to your supplement regime that just might extend the length and quality of your life? That makes resveratrol a single nutrient definitely worth consideration.
Resveratrol: The science surrounding resveratrol is so compelling that it is fast becoming one of our all-time favorite antioxidants, and we believe one that shows real promise of health benefits.
Resveratrol, an antioxidant found in grape skins (and red wine), berries, cocoa and peanuts has been called the modern-day fountain of youth for a very compelling reason: it appears to slow down aging and even increase the life span of human cells.· Much of the well-deserved fanfare surrounding resveratrol has centered on its role in enhancing longevity, but new research is expanding this focus and showing this potent antioxidant may influence many aspects of your health, including that of your brain.
Resveratrol is unique among antioxidants because it can cross the blood-brain barrier to help protect your brain and nervous system.
Resveratrol may help to boost brain and heart health, while slowing down the aging process through its ability to modify inflammation in your body. Chronic inflammation is not beneficial, and in fact has been linked to numerous chronic diseases including heart disease.
Resveratrol also seems to produce many similar benefits as exercise, including lowering insulin levels, which is a key to fighting disease and staying young.
Are you Feeling lethargic? No pep in your step? Afraid your aging too fast?
You see, scientist have been researching the aging process and theyve discovered that 2 foods tower
over all others when it comes to fighting and reversing premature aging. In fact, these foods have been studied extensively by
Harvard scientists for their many healing properties and proven to
deliver real results.
OK so what are the secrets
1. Super Anti-Aging Food: RED WINE
(Who doesnt love a gloss of red wine, now it doesnt mean that chugging a bunch of red wine will wind back the clock! Really, theres one primary ingredient in red wine that makes you more youthful and vibrant. That ingredient is called Resveratrol.
In a review study conducted by Harvard University - which released their findings in the Nutrition and Metabolism Journal on January 3, 2006 they found that Resveratrol can extend the life expectancy of every organism that, so far, its been fed to, including yeast, worms,
and fruit flies.
In their own words, The wonder substance seems to work in the same way as does drastic calorie cutting. Dramatic
reduction of calories has been shown to increase the life span.
There are many Resveratrol supplements out there on the market but the scientists recommend you be wary and find a
quality brand that truly delivers on its promises, such as Vivix
2. Super Anti-Aging Food #2: DARK CHOCOLATE
Yes I said chocolate But that doesnt mean you can eat chocolate bars all day! The real benefit of chocolate comes from the extremely high
level of antioxidants found inside the active components.
In fact, a Harvard study reviewed 136 scientific articles published between 1996 and 2005 on chocolate and its,ingredients.
Their analysis found that eating 50 grams of dark chocolate per day may reduce the risk of heart disease by 10.5 percent. In addition, eating dark chocolate may lower the risk of dying from heart disease by 19 percent.
Plus, dark chocolate contains antioxidants universally praised for their ability to fight off free radical damage (which causes aging) and make you look and feel younger. And no substance contains higher concentrations than pure cocoa extract, which incidentally is another source of resveratrol.
In the September 24, 2008 edition of the Journal of Agricultural and Food Chemistry, scientists report that cocoa powder, baking chocolate and dark chocolate all have significant levels of resveratrol, a naturally occurring antioxidant.
This study shows that the levels of resveratrol found in cocoa and chocolate products is second to red wine among known sources of resveratrol and forms yet another important link between the antioxidants found in cocoa and dark chocolate to other foods, says David Stuart, PhD, Director of Natural Product Science at The Hershey Company who partnered with Planta Analytica to conduct this study.
Researchers reported online in Circulation: Journal of the American Heart Association in 2009 that exercise (specifically endurance exercise) may slow telomere shortening. Telomeres are little DNA structures found on the end of chromosomes. Think of them like the caps at the end of shoelaces. They protect the ends of the chromosomes from genetically unraveling, which could lead to disease. As we get older, cells divide, telomeres shorten with each division, and eventually cells die. Some research has linked shortened telomeres to higher rates of death from heart disease and infections, cognitive dysfunction, and certain cancers.
This study compared telomere length in white blood cells of middle-aged lifelong runners, healthy middle-aged people who did not exercise, and younger distance runners. Theres no surprise, the researchers found the exercisers had less loss of telomere length than the non-exercisers. The exercisers also had substantially higher amounts of proteins that help preserve telomeres.
This information reaffirms a study published last year that involved 2,400 twins. Researchers split the twins up, one group exercised, one group was sedentary. The twins that exercised had longer telomeres. One the flip side, a couple of other studies have shown an association between smoking and obesity and shorter telomeres.
In relation to diet, preliminary research has shown Resveratroll increased the life span of the animals in the studies, likely due to its affect on telomeres. Resveratrol is found in the skin of red grapes and is a constituent of red wine. Its produced by the plant in response to attack by bacteria or fungi. Note: bromelain enhances resveratrol absorption, while quercitin competes with it (and wins).
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The subject of polyphenols when initially tackled by the industry several years ago used the French paradox as the marketing tool and focused by and large on grape seed and skin extracts, or red wine powder. However, science and innovation have created a thriving market segment now dominated by serious contenders for market share such as DSM and Seppic.
Polyphenols are now being sourced from not only grape, but green tea, nuts, green coffee, cacao, apple, soya, and even seaweed with each marketed using a unique story regarding benefit to the consumer. Not only is the source of polyphenols becoming increasingly diverse, but in my view the most exciting industry development is the identification, isolation and extraction of the beneficial molecule from the extract itself. Awareness and availability of ingredients such as resveratrol, quercetin, rosemarinic acid, caffeic acid, gallic acid is increasing and inclusion of these ingredients within a suppliers portfolio is becoming more prevalent.
Resveratrol is naturally found in grapes and red wine, mulberries, peanuts and Japanese Knotweed, although it is debatable whether the levels at which it occurs naturally can provide a health benefit when consumed at typical daily levels driving the need for highly purified products. Resveratrol has been shown to protect tissues and cells from oxidation damage, has protective cardiovascular effects, and has potential neuroprotective properties. Vivix Cellular Anti-Aging* Tonic which is a revolutionary breakthrough in the fight against cellular aging. Developed after years of research by Shaklee Corporation, the number one natural nutrition company in the U.S., Vivix is the world best anti-aging supplement. In laboratory studies, Vivix ingredients have been shown to impact the four key mechanisms of cellular aging.*
A 30 day supply of Vivix delivers the equivalent amount of resveratrol found in 3,000 glasses of red wine, and Vivix ingredients are 10x more powerful in slowing a key mechanism of aging than resveratrol*.
As well as companies actively investing in manufacturing, other companies are entering the market via alliances and distribution agreements. For example, earlier this year A.Holliday in the USA agreed exclusive distribution rights outside of North America for their Teawell 95 product with Tate & Lyle. Teawell 95 is a 95% concentration of the bioactive green tea component, epigallocatechin gallate.
Different approaches to market entry are broadening the supplier base across the regions, as well as the ingredients available all supporting growth of the market and raising product awareness. This market segment continues to thrive despite the gloom of the past two years, with companies continuing to invest in new product development. As with other nutraceutical ingredients, strong drivers, such as aging populations, are supporting the health and wellbeing industry and those companies active in this sector have been rewarded by better performance when compared to other manufacturing industries.
Past research have shown that the sirtuin activator resveratrol extends the health span of mice and increases exercise tolerance. Resveratrol occurs naturally in several plants, most famously the skins of red grapes and Japanese Knotweed; unfortunately for the would be life-extensionist, a human would have to consume upwards of 1000 bottles of red wine in order to approach the dose of resveratrol used in the rodent studies. What we needed was an orally bioavailable, clinically useful drug with the same specificity but much higher activity.
In 2007, a collaboration between the pharmaceutical company Sirtris and the research group of David Sinclair (who co-founded Sirtris, and whose lab was responsible for the observation that resveratrol extends the life span of mice eating an unhealthy diet) resulted in the development of sirtuin activators that are a thousand times more efficacious than resveratrol . While longevity data is not yet forthcoming, the compounds do have a significant influence on glucose homeostasis, and are being touted as a potential prophylactic or therapy against type II diabetes:
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
Calorie restriction extends life span and produces a metabolic profile desirable for treating diseases of aging such as type 2 diabetes. SIRT1, an NAD+-dependent deacetylase, is a principal modulator of pathways downstream of calorie restriction that produce beneficial effects on glucose homeostasis and insulin sensitivity. Resveratrol, a polyphenolic SIRT1 activator, mimics the anti-aging effects of calorie restriction in lower organisms and in mice fed a high-fat diet ameliorates insulin resistance, increases mitochondrial content, and prolongs survival. Here we describe the identification and characterization of small molecule activators of SIRT1 that are structurally unrelated to, and 1,000-fold more potent than, resveratrol. These compounds bind to the SIRT1 enzymepeptide substrate complex at an allosteric site amino-terminal to the catalytic domain and lower the Michaelis constant for acetylated substrates. In diet-induced obese and genetically obese mice, these compounds improve insulin sensitivity, lower plasma glucose, and increase mitochondrial capacity. In Zucker fa/fa rats, hyperinsulinaemic-euglycaemic clamp studies demonstrate that SIRT1 activators improve whole-body glucose homeostasis and insulin sensitivity in adipose tissue, skeletal muscle and liver. Thus, SIRT1 activation is a promising new therapeutic approach for treating diseases of aging such as type 2 diabetes.
Standard qualifications: humans and mice have quite different metabolic needs, and it remains to be seen whether the drugs will work in humans. Its also important to keep in mind that the effect of long-term systemic sirtuin activation is unknown, and may even be harmful in certain key tissues (like the brain).
The work represents the culmination of a huge amount of progress in a relatively short time: in less than 15 years, the sirtuin story has evolved from basic biology in the simplest model organisms, through exhaustive (though essential) testing in larger animals, into a source of potential therapies for a major human disease.
Furthermore, for the first time we have a clearly defined path toward the regulatory approval and widespread use of a compound that could be used as a frank anti-aging drug. There are significant practical barriers to testing a longevity-enhancement therapy, not least of which is the time scale of the necessary studies. There are also institutional barriers: despite the inefficiency of treating every disease of aging separately, theres still major reluctance on the part of funding and regulatory agencies to see aging as a disease per se (though even over my relatively short career in biogerontology, I have seen this changing for the better).
But a drug for which a clear clinical indication existed, shown to be efficacious against a widely acknowledged disease, could pass over regulatory hurdles and enter the clinic much more smoothly. Since clinicians could point to a specific short-term benefit of the drug, public acceptance (sometimes curiously hard to achieve in discussions of explicit longevity enhancement) might also come more readily. (One question: in advertisements, would the manufacturer have to warn patients that the drugs may slow aging and extend the life span?)
In this blog, I am going to talk about some on the red wine cholesterol benefits, as well as telling you what causes them and how you can experience the same sort of benefits using additions that do not contain alcohol.
During the Nineties, a strange phenomena was observed known as theFrench Paradox. This anomaly was that though the French eat a diet which is very high in saturated fats, theyve a comparatively low incidence of heart illnesses. In other words, though eating things that should have resulted in a lot of conditions like coronaries and strokes, they have an exceedingly low occurrence of these sicknesses when compared to other countries like the united states. This showed clearly that there should be something that the French are doing or eating that is good at fighting these conditions. The Italians also are known to live longer lives than average.
Theres a well known connection linking ldl cholesterol and cardiovascular sicknesses, which is why the French cholesterol levels were checked. It was surprising to discover that, though you might expect their cholesterol levels to be really high, they were really within normal limits. How was it that they manage that?
Research concluded that the reason why their cholesterol levels are so small is because they consumed lots of red wine. These red wine cholesterol advantages had not been suspected during the past, and initially scientists were unable to say why it was that red wine had these advantages. Through in depth research they have uncovered substances which occur in red wine regarded as plant sterols, the strongest of which was resveratrol. Resveratrol comes from grapes, and is present in red wine simply because red wine is created with the flesh and skin on the grapes.
Studies have shown that ingesting tiny quantity of red wine every day might have a big benefit for the heart procedure. Reductions in the occurrences of illness have been noted to reach to about 30%. This will be considered proof belonging to the efficacy of red wine in fighting cholesterol.
Sadly, drinking high amounts of alcohol can cause different poor health results. For instance, in France there is a high incidence of liver disease which is due to the high consumption of alcohol. As it is not wise to trade one thats for another, its a good idea to learn how to get the red wine cholesterol benefits without the side effects of alcohol.
This is why the researchers have been experimenting with resveratrol extracts, and theyve found that when extracted and concentrated straight from the grape sources, resveratrol is much more effective. They have found that when is fed to mice and other small animals it extends their lives by 30 to 60%. As well as expanding life span, it reduces cholesterol, and helps to stop illnesses from forming. Many of these sicknesses often associated with old age, so resveratrol has been shown to be efficacious in preventing these diseases and works effectively as an anti-aging agent.
As you can see, the most effective way to get red wine cholesterol benefits is to take a supplement containing a high concentration of resveratrol. There are quite a few different products for sale on the market right now, and a few of them are much better than others. The one I recommend you try is Vivix because it contains high concentration. A 30 day supply of Vivix delivers the equivalent amount of resveratrol found in 3,000 glasses of red wine, and Vivix ingredients are 10x more powerful in slowing a key mechanism of aging than resveratrol.
Anti-aging means slowing, forestalling or reversing the aging process and since recorded history, the human race as asked for the spring of youth. In the 21 century we have proved that at the cellular level, reversing aging is attainable. Scientists accept that random damage occurring within cells and among cellular molecules are answerable for many age-implicated changes we see in our bodies. Cellular damage through oxidizing agents, illness, genetics, etc, is what causes getting older. Theres overwhelming evidence that resveratrol can extend the lives of cells and mend cell damage, so helping us live longer and feel better. Scientists have discovered Resveratrol is a naturally occurring phenol anti-fungal agent found in grapes and other plants.
In a state Institute of aging conducted a study on calorific intake and resveratrol. The scientists compared two groups of overweight mice on a fatty diet. One group was given a high dose of resveratrol. The overweight mice receiving resveratrol were more healthy and lived longer than the other oversized group. In a follow-up study, scientists found that, when started at middle age, resveratrol slowed age-implicated health Problems in mice on the standard diet. For more information about this actual study visit the national Institute of Health web page.
Age defying therapy is a latterly new medical discipline which aims for the very best quality of health for people during the latter stages of their lives. Proponents of anti-aging care say it is possible to slow or reverse the aging process with medical and systematic interventions. Preventative measures like nourishment, additions and hormonal and cell based treatments can increase longevity and living a good life.
We have all heard about how the French and Italians have low rates of coronary disease and other sickness even though they eat high fat meals. Research has concluded it is because they consume red wine, which is made from grapes, thus they consume exaggerated levels of resveratrol that repairs and protect cells. Scientists have concluded that there are four cellular anti-ageing mechanisms that we encounter each day theyre :
1.Damaging assaults to our DNA Genetic regulation
2.Control over the balance between damage and repair of cells, including whether a cell lives or dies
3.Mitochodria efficiency - Every cell of the body contains many tiny organelles called mitochondria
3.The energy of each living cell, and the way in which that cells energy decreases as we grow older Cellular damage that will compromise cell integrity and longevity
Research has found that we can influence the biological mechanism of cells to repair, replace or improve the current cell. For instance, a cell may replace itself with a weaker cell because it does not have the right nutritional foods available ; thus degeneration of the cell starts. A cell can replace itself with the cell of the same strength, although this is not a degeneration of the cell it implies that the cell remains the same and does not improve. But with right nourishment either by food or additions, a cell can replace itself with a stronger cell, this replacement with a better cell is called regeneration and the essential nature of what cellular contra-aging is about.
Revolutionary products are entering the main line as they hit the market. Eventually, analysts have been looking at the naturally source ingredients that may benefit us, just like they have of our many ancestors of the past. These products are made of naturally source ingredients that really do help with the cellular aging of your skin.
You have heard of the natural component that is present in Red Wine that provides a spread of health advantages to people who consume it on a consistent basis? Well, the ingredient is called Resveratrol. Analysts have finally studies organic ingredients that have been around for many years. There had to be a reason explaining why all our ancestors never experienced the sort of sicknesses and issues that are being experienced in todays society.
Researchers years to start looking in the right direction, we are just glad that they did. Because of this, these "old" ingredients are being incorporated into products that offer consumers great benefits. And, one product, Vivix particularly comes in a supplement form that contain concentrated resveratrol the equivalent of drinking 100 glasses of red wine per serving.
Resveratrol a natural compound found in red wine, grapes, blueberries, peanuts and other plants has been found to promote longevity and health in a variety of ways. For example, scientists have found evidence it prevents heart disease, helps keep weight under control, normalizes cholesterol levels and may prevent diabetes. Now theres another benefit to add to this remarkable list of benefits: it could prevent some of the top causes of blindness.
Vision researchers at Washington University School of Medicine in St. Louis have documented that resveratrol stops out-of-control blood vessel growth (angiogenesis) in the eye. This discovery means resveratrol could preserve vision in three major blinding eye diseases: age-related macular degeneration (the leading cause of blindness in Americans over 50); diabetic retinopathy, which causes vision loss in about 20 percent of people with diabetes; and retinopathy of prematurity which occurs when premature babies experience an obstruction of blood flow into the retina a condition that blinds 50,000 infants each year.
A great deal of research has identified resveratrol as an anti-aging compound, and given our interest in age-related eye disease, we wanted to find out whether there was a link, Washington University retina specialist Rajendra S. Apte, MD, PhD, the studys senior investigator, said in a statement to the media. There were reports on resveratrols effects on blood vessels in other parts of the body, but there was no evidence that it had any effects within the eye.
So Dr. Aptes research team decided to test resveratrol on mice that develop abnormal blood vessels in the retina after laser treatment. Their findings, published in the July issue of the American Journal of Pathology, showed that when the rodents were given resveratrol, the phytochemical prevented the growth of abnormal blood vessels. In fact, abnormal blood vessels that already existed actually began to disappear.
When the scientists examined cells of the animals blood vessels in the lab, they found a new pathway known as a eukaryotic elongation factor-2 kinase (eEF2) regulated pathway that is behind resveratrols eye-protective power.
We have identified a novel pathway that could become a new target for therapies. And we believe the pathway may be involved both in age-related eye disease and in other diseases where angiogenesis plays a destructive role, Dr. Apte stated. This could potentially be a preventive therapy in high-risk patients. And because it worked on existing, abnormal blood vessels in the animals, it may be a therapy that can be started after angiogenesis already is causing damage.
Whats more, the resveratrol-mediated pathway Dr. Aptes laboratory has identified may be active not only in several blindness-causing eye diseases, but in cancers and atherosclerosis, as well. That means it might be possible to use resveratrol to not only protect and improve eyesight but to prevent cardiovascular disease and some types of malignancies, too, according to Dr. Apte.
Any discussion on an antioxidant should begin with explaining why they are important so if you already know about free radicals then skip to the next paragraph or you can continue on here for a refresher. Oxygen is necessary for life but, unfortunately, oxygen also causes chemical reactions within the body that generate free radicals. Free radicals are molecules that are missing electrons and are therefore unstable. In order to stabilize themselves, they must steal electrons from other molecules in the body which causes something called oxidative stress. Oxidative Stress is very damaging to the bodily tissues and causes wrinkles, muscle loss and a whole host of degenerative diseases. Oxidative stress is an ongoing process that cannot be stopped (because we need oxygen in order to live) and if left unchecked, it will eventually cause the tissues to breakdown so much that death will ensue. Luckily for us, we have discovered that antioxidants help to slow this process and that is why antioxidants are praised so highly and are considered so important.
Resveratrol or trans-resveratrol is in the polyphenol category of antioxidants and is produced in the skin and seeds of purple or red grapes as their natural means of inhibiting mold growth. It has also been found in Cocoa Powder, baking chocolate and Dark Chocolate products with cocoa powder containing the highest of those three but not more than red wine. Resveratrol is also produced by raspberries, mulberries and peanuts but at lower levels. Muscadine Grapes are known to have the highest levels of Resveratrol because their skins are thicker than most grapes and they also contain more seeds than most other varieties.
Resveratrol is an alcohol soluble compound which explains why Red Wine is known for its antioxidant power. Red wine contains anywhere from 1.5 to 3 milligrams (1500-3000 micrograms) of Resveratrol per litre while grape skins and seeds can yield 50 to 100 micrograms per gram making red wine a much more concentrated form of Resveratrol. Unfortunately for most of us, drinking any more than one glass of red wine per day actually offsets the benefits of Resveratrol and increases your risk of disease. Also, some red wine may not contain any Resveratrol at all unless the grapes were grown in damp/moldy areas or the grower refused to use fungicides since Resveratrol is the plants defense against fungus and mold.
So what is so special about Resveratrol?
This powerful antioxidant is thought to fight Alzheimers Disease and other brain disorders due to its very special ability to cross the blood brain barrier. Because it can cross this barrier, it is able to protect the brain and nervous system from oxidative stress and the diseases that come from it.
Resveratrol is also know to switch on a gene called SIRT1 within our bodies that can increase longevity or life span up to 70% (about 50 years) and is known to fight the signs of aging along with increasing your fat burning potential. It has been shown to help your liver metabolise fat and then helps to break down stored fat contained in your white adipose tissue.
It can also help to fight Cancer and Heart Disease while lowering blood pressure, raising good cholesterol, preserving red blood cells, protecting your body against fungal infections, assisting your anti-inflammatory response and helping to prevent blood clots that lead to stroke. In addition to all that, it has also been shown to protect the liver and pancreas, reduce cataracts, improve coordination, encourage bone health, reduce disk deterioration, protect joints, guard against Parkinsons disease, improve erectile performance and help to regulate cell health while protecting against adverse cell changes.
Recent studies have even shown that Resveratrol can help to reduce and possibly even reverse the effects of alcohol induced fatty liver disease. Alcohol induced fatty liver disease occurs when the liver becomes damaged from alcohol abuse and cannot break down fat efficiently. Since the liver is unable to break down fat, the fat starts to build up within the liver eventually causing liver diseases like cirrhosis or fibrosis which can lead to total liver failure if left untreated. Our livers contain two proteins called SIRT1 and AMPK which are vital for breaking down fat in the liver but alcohol abuse tends to inhibit the ability of these proteins to do their job. Resveratrol has been shown to increase levels of these two proteins and their ability to breakdown fat. In addition to this, the higher levels and increased activity of SIRT1 and AMPK helped to decrease levels of proteins that are involved with the build up of liver fat and also increased levels of a hormone called adiponectin which metabolises fat so not only does it help to break down existing fat but it also helps to metabolise fat more efficiently.
Growers have even found that coating their crops with trans-resveratrol can help to prevent mold, yeast, aging and microbial related spoilage.
If you chose to eat dark chocolate for the antioxidant benefits of Resveratrol then choosing a chocolate with the highest percentage of cacao will usually reap more benefits since it is the cocoa powder which contains the compound. 6.7 grams of chocolate a day, which is less than half a candy bar a week, provides the most benefit so dont think this gives you free reign to gorge yourself on chocolate.
Its been previously discussed how Resveratrol is found in red wine. Well, red wine is famous for its contributions in keeping ones heart healthy, and Resveratrol is understood to have multi-modalities of heart-tending actions.
If you haven't heard ofThe French Paradox? well, it is a generally used expression to mean the direct organisation between alcohol consumption and fatty diets. See, most French people smoke and their diets contain high levels of saturated fat. However they are also lovers of red wine, in fact it part of their daily life, and red wine is understood to protect our bodies from cardiovascular illnesses. The secret is in their consumption of red wine which has resveratrol. Resveratrol is a phytoalexin produced by some plants to ward off pathogens like bacteria or fungi. Latest advances in technology allow Resveratrol to be synthesized chemically.
Since red wine already contains high levels of Resveratrol, what makes this cardiovascular illness prevention all the more fast is the presence of flavonoids, working hand in hand with Resveratrol.
Red wine contains more Resveratrol than regular grape juice because of the fermentation process it undergoes. Grape skin contains the highest natural concentration of Resveratrol. Other sources of Resveratrol include peanuts, eucalyptus leaves and Eastern knotweed with Japanease knotweed being the primary source for supplement extracts. Aside from that, it also helps keep cancer cells and phytoestrogen from junk food in check. In relation to this naturally is the cardiovascular system.
The heart system for the transport of nutrient elements, gases, hormones, blood cells, nitrogen waste products and so on, from and to cells in the body to keep it in homeostasis. Coronary disease in particular is the premiere cause of death in the united states, England, Canada and Wales and is quickly becoming a pandemic because of the nature of our daily diet consumption. Statistics indicate that coronary disease claims the life of one individual each 34 seconds in the USA alone.
Apart from better muscled function, resveratrol also serves as a blood thinning agent, minimizing system damaging clots that form because of impurities in blood. This in turn helps in avoiding damage to the arteries that are commonly found in occurrence when blood clots break free and circulate.Resveratrol is indeed a wonderful discovery in the sector of medication. Neither will it benefit if you overcompensate your existing diet with a bigger dose. Everything in life is best in small doses and this includes the most delicious food, and the best medication.
There is a big difference in cardio health protection among alcohol drinkers. The answers quite simple : liquors and lagers dont contain as much Resveratrol as wine, especially red wine. Also, liquors and beers are harmful to the stomach tract ; they abuse our livers and kidneys when not taken carefully.
A large amount of people still associate the presence of Resveratrol with other alcoholic drinks ( not just wine ). And thats the reason why the more current pills and capsules developed to concentrate Resveratrol were flooded with information on how Resveratrol originally comes from grapevines and not from the alcohol content.
Resveratrol diet supplements have been becoming increasingly popular since they were broadcast on 60 minutes|one hour in January 2009. Why have they become so popular and what are they able to do for you?
Resveratrol is a polyphenol antioxidant that is attained from beans, berries and some peanuts. Almost all of the resveratrol diet supplements that are made today come from the Japanese knotweed. They have been used in Japan and China for many decades as a treatment for a range of conditions such as heart and liver sicknesses, inflammation, lethargy, infections and for weight loss.
Scientists have studied resveratrol at length and have found that it has many health benefits.
Resveratrol diet supplement is perhaps most typically renowned for its anti aging properties. They do this on more than one front.
1. It turns on vitalitygenes called sirtuins. Sirtuins help insulate our cells from decaying and also helps with restoring imperfect cells.
2. The antioxidant forestalls the development of free radicals that damage our cells and also eradicates free radicals that do develop.
Another way that resveratrol diet supplements can benefit our health is by decreasing our weight.
Those longevity genes called sirtuins can help in other ways apart from anti-aging. When resveratrol turns on the sirtuins, it is activating the same gene that burn calories, in a similar way as fasting. When fasting happens, our cells start to burn off the excess fat in our body. This burning of fat in itself uses extra energy and more weight is lost.
The other major disease that resveratrol is being investigated for is cancer, in which it seems it has potential to prevent different cancers in many ways. Although these are some encouraging results the analysis is at an early stage.
Because resveratrol dietary supplements can protect our cells and therefore lengthen their life, this could have a follow-on effect of shielding our bodies from lots of other infirmities such as heart problems, neurological grouses, Alzheimers, rheumatoid arthritis and can improve energy levels, immune system and breathing Problems.
Resveratrol is a totally natural product and has a low degree of complications. Its true potential still has to be revealed but it certainly has made a good start.
The three best natural sources of resveratrol are red wine, Japanese knotweed and peanuts. There are some other resveratrol supplement sources but all of them derive their resveratrol from one of the above three.
Red wine is brim-full of resveratrol, well not full per se. In fact, its not like you could evaporate the wine and have a pile of resveratrol sitting there. But the best thing about wine is the way you sip it. Usually, you pour some in your wine glass and sip at it. And then once its in your mouth, it really sits there for a second before swallowing it. What makes this great is that resveratrol is best absorbed in the mouth. This extra second gives the resveratrol an opportunity to get soaked up into the blood straight away. So even if theres not tons of resveratrol in wine, it is getting absorbed far better than additions and other sources.
A more obscure source of resveratrol is Japanese Knotweed. This is obscure if youve not had exposure to it, but to some people theres nothing obscure about it. It just so happens Japanese Knotweed is one of those invasive weeds that you can not kill. In fact its listed as an invasive plant by more than 13 states of the USA. But what makes it invasive is also what makes it good. Because it can grow anywhere, resveratrol supplement makers use it as their resveratrol source. It just so happens, that its also quite edible and is used in the North East as a substitute for rhubarb.
Finally, on our list of three most important sources of resveratrol, is peanuts. Yes, the kind that grown in the ground. Peanuts are a fine source of resveratrol. While you may think they are greasy and unhealthy, were you aware that people who continually ate peanuts had a lower body fat index than the remainder of us? So the next time youre sat at the bar, ask for some peanuts so you can fill good about being there.
There is a long standing debate on how much alcohol a person should have everyday. Some people do not believe that red wine is a good source of health benefits, while other doctors and nutritionists believe it is. Resveratrol which is found in red wine is a case in point, it is also found in other foods such as peanuts however the amount is nothing compared to that in the grapes of red wine.Some of the most abundant natural sources of resveratrol are the muscadine, labrusca, and vitis vinifera species of grapes.
The more grapes used in the fermentation process of the wine the higher the resveratrol concentration will be. Since a large quantity of grapes skin is significantly removed from the production of white wine, the red wine becomes the most useful and reliable source of resveratrol. Resveratrol is a natural part of the defence system of plants, and is mainly responsible for the protection of plants against certain diseases. Thats why the antioxidant properties of resveratrol can also be made to form a part of our own defence system.
Resveratrol which is harvested from Japanese knotweed is used in several Japanese and Chinese medications that are used for treating allergy, fungal, lipid and other diseases. Resveratrol has been proved to reduce the onset of heart diseases in humans through the use of consuming a lot of red wine.
Despite their diets which are high in saturated fat, the French have been proven to have a reduced risk of heart disease. The resveratrol in the grapes of the red wine must have had an impact on this fact. Alcohol consumption is never recommended but there is no proof of any side-effects of drinking red wine in moderation. Cancer-prevention is another benefit that is currently being researched in resveratrol.
Resveratrol is also believed to be the anti-aging secret of centenarians who proliferate in cool climates and places where grapes are grown since this particular enzyme is said to have anti aging properties. Drinking red wine moderately can make an older person look younger and healthier. This can make older people look and feel younger.
1-2 glasses of red wine is the recommended daily dose and can reduce the risk of cardiovascular disease. Exceeding 1-2 glasses of red wine daily is not recommended because the negative effects of alcohol will outweigh the positive effects of resveratrol. There are however alternatives sold as supplements which can provided higher dosages of resveratrol without the need to consume alcohol.
Most people have heard about how drinking one glass of red wine each day has been medically proved to lead to a healthier you, but why is this? The answer lies in an ingredient called resveratrol which not only helps to keep your heart healthy, but also aids in burning calories a benefit which explains why so many people have replaced their regular dinnertime beverage with a glass of red wine resveratrol.
When plants come under attack by certain bacteria and/or fungi, they produce an antibiotic known as resveratrol. These antibiotics also known as phytoalexins are found in many plants such as blueberries, cranberries, raspberries, and one of the highest natural resveratrol producers: peanuts. Red grapes and the skins of red grapes also contain large quantities of this substance which are what red wine resveratrol is made from. So it is to obtain the health benefits of the resveratrol found in red wine by consuming just one glass every night.
What is not so well-known is that this insight was first observed by examining the French culture in connection to their overall health. Researchers documented that the normal French diet is composed of foods with high fat contents like cheese and creams, and that the French also drank red wine when they ate. And so it was surprising to learn that even though they regularly ate this type of diet, the rate of heart disease in France was among the lowest worldwide, and resveratrol has been assumed to be the cause of their consistent health.
While resveratrol has been proven to stimulate an assortment of positive effects on a persons health, weight loss is one of the most popular points of focus. Being a powerful antioxidant, resveratrol aids in the blockage of fat build-up within the body as well as calorie control, and can even hamper the development of diabetes. And as if these benefits werent already impressive, red wine resveratrol has also been shown to protect against heart disease, subdue inflammation, and yield some results with regards to anti-aging. You can also obtain resveratrol in the form of pills and other supplements, but in order to get the most out of this powerful antioxidant, its a good idea to integrate fresh nuts and berries into your diet.
Solid scientific evidence has yet proves without a doubt the power of resveratrol, but for people who have experienced the healing effects firsthand, as well as the preliminary studies carried out, this antioxidant has become a benefit to the health and fitness arena. One glass of wine each night could very well prompt your ultimate health and well-being.
104. Resveratrol The medical world is really intrigued with resveratrol a specific antioxidant chemical which exists in plants and foods with red skins, some nuts and chocolate . This has stirred up a debate worldwide regarding the truth behind Resveratrol. Nobody is actually aware of the exact dosage of intake of Resveratrol Capsules that is recommend for humans as most studies have been done on rodents. Resveratrol reviews are being carried out by print as well as electronic media constantly. Many doctors are also in a dilemma as to whether they should prescribe this wonder supplement to their patients.
The quest for eternal youth is an intrinsic attribute in any human being. So when people discover a supplement which will help them in this cause they naturally become very excited. Resveratrol has shown to enhance performance in athletes. Skin of grapes, berries, lot of herbs, peanuts, and even Japanese knotweed posses this amazing antioxidant.
Because there are numerous sources from which Resveratrol can be derived. Many companies have introduced their own Resveratrol supplements to cater to this frantic demand of Resveratrol supplements, especially in the U.S. Markets have been flooded with all these supplements. So one needs to make a careful review of all the Resveratrol supplements available and then chose accordingly. Only genuine products from reliable companies should be purchased.
Resveratrol provides a diverse range of benefits. It reduces the chances of heart attack, strokes, brain cell degeneration and protects a person from the harmful effects of toxins and radiation on the body. It enhances the buildup of muscle mass thereby increasing the stamina and energy levels. It posseses anti-inflammatory and anti-carcinogenic properties. It is extremely beneficial in the prevention and treatment of diabetes and brain diseases such as Alzheimers disease in aged people. The quality and the tenure of life is improved and extended significantly with the intake of Resveratrol supplements.
Resveratrol supplements and also benefit your pets
Most of the supplements available in the USA contain extracts of the root of Japanese knotweed, a medicinal plant used in Asia to treat inflammation, heart and liver conditions, and skin and lipid problems. The actual effect of Resveratrol supplements is still not conclusively proved. One should keep in mind that professional medical guidance and consultation is advisable before taking any of these supplements.
Resveratrol is a naturally occurring compound present in various fruits and plants. Grapes, red wine and peanuts are most commonly known sources of Resveratrol. Red Wine is often considered an important part of the diet.
Red wine contains this natural compound which has a number of benefits for us to be healthy. Drinking red wine (that contains Resveratrol) can reduce the risk of a heart attack as it cleans the blood vessels. Natural resveratrol is an antioxidant, and can slow down aging of cells in your body. Cancer and cardiac diseases can help be prevented by Resveratrol because of its anti-mutant and anti oxidant properties.
When you consume Resveratrol, you tend to live a healthier and less risky life. the majority of studies have been carried out on mice and other organisms, and the experiments have shown successful results. There are no side effects present, and this is because of Resveratrol being a natural compound. It does not harm your body, even if taken in large amounts. However the health supplementary pills that use Resveratrol as the main ingredient in them all come with a dosage. It is good to follow the dosage properly for the best results, it is generally not recommended for children.
Researchers are very optimistic about the good effects of Resveratrol for healthier living.
New research published in the journal Nature reveals that pancreatic cancer takes 20 years to grow to the point where it is diagnosed by conventional medical doctors. This was determined by sequencing the DNA of cancer tumor cells from deceased patients. Because cancer mutations occur in growing tumors at a known rate, scientists were able to map the timing of the development of full-blown pancreatic cancer tumors.
So this means you have twenty years to change your eating habits such as reducing sugar intake, because cancer tumors rely on sugar to grow. Previous research also suggests that the antioxidant resveratrol, which naturally occurs in grape skins, can weaken pancreatic cancer cells and increase their vulnerability to chemotherapy.
"Resveratrol seems to have a therapeutic gain by making tumor cells more sensitive to radiation and making normal tissue less sensitive," said lead researcher Paul Okunieff, chief of radiation oncology at the University of Rochester Medical Center.
In a study published in the journal Advances in Experimental Medicine and Biology,Okunieff and colleagues treated a group of pancreatic cancer cells with 50 mg of resveratrol, then iodized them to simulate the action of chemotherapy. Another group of cancer cells was iodized without undergoing any resveratrol treatment.
Pancreatic cancer has long been known to be particularly resistant to chemotherapy. The researchers discovered that because the pancreas is continually producing digestive enzymes and pumping them into the duodenum, these enzymes actually flush away chemotherapy chemicals before they can have much impact.
But in pancreatic cancer cells that had been treated with resveratrol, the cell membrane proteins responsible for this flushing had their functioning hampered. In addition to becoming more sensitive to chemotherapy, the cells also became more likely to undergo programmed death (apoptosis) due to the increased production of reactive oxygen species.
While the reason for the decreased pumping action was not clear, it may have been a side effect of yet a third observed effect of resveratrol treatment: The mitochondria of the cancer cells was damaged, with its membranes depolarized. Because mitochondria are the energy source of the cell, damaged mitochondria hampers the cell's general ability to function, including its ability to flush out chemotherapy drugs.
As a naturally occurring ingredient of red wine, resveratrol has drawn much attention from researchers investigating whether it might be responsible for wine's well-documented health benefits. Like all antioxidants, resveratrol is known to remove free radicals from the blood. Free radicals are known to be linked with cancer, inflammation related to cardiovascular disease, and the effects of aging.
A number of studies have suggested that the resveratrol has anti-cancer benefits, from preventing the development of skin cancer in mice exposed to ultraviolet radiation to reducing the risk of esophageal or colorectal tumors in mice and rats exposed to carcinogens. It has also been shown to induce apoptosis in human fat cells under certain specific circumstances.
"Antioxidant research is very active and very seductive right now," Okunieff said. "The challenge lies in finding the right concentration and how it works inside the cell."
The highest concentrations of resveratrol are found in grape skins. Peanuts contain about half as much resveratrol as grapes, while blueberries and bilberries contain only about 10 percent as much.
While the resveratrol content of wine varies widely depending on the variety of grape, when and where it was grown, and how long it was fermented, the high level tends to be 30 mg per ml. This is lower than the dose used in the current study. But Okunieff said that higher doses should be safe as long as they are taken under a doctor's supervision.
"While additional studies are needed, this research indicated that resveratrol has a promising future as part of the treatment for cancer," he said.
Approximately 33,000 new cases of pancreatic cancer are diagnosed in the United States every year. Patients have a very low rate of survival, in part due to the disease's resistance to chemotherapy.
Resveratrol is the protective bioactive nutrient found most commonly in the skin of red grapes, peanuts and cacao. Resveratrol provides a protective barrier against disease and fungus in plants which is also beneficial to human health. A wealth of information exists to support the function of resveratrol for brain rejuvenation, cardiovascular repair as well as influencing the metabolism of fat leading to natural weight loss.
Resveratrol Can Help Prevent Heart Disease
Proanthocyanadins from the grape family have long been associated with heart health, and resveratrol now takes its deserved place at the top of the cardiovascular friendly nutrients list. The lining of the cells within the artery are known as the endothelium, and are very sensitive to dietary abuse caused by hydrogenated fats, excess sugar, cortisol and insulin. Damage to the endothelium leads to high blood pressure as well as micro cracks which are filled with foamy plaque, increasing the risk of heart attack.
The results of a peer reviewed study published in the online journal PLoS One, resveratrol was found to be a natural anti-aging agent and exhibited many of the same characteristics as calories restriction. This natural defense nutrient is able to act at the genetic level to influence genes which promote cardiac dysfunction and glucose metabolism. In addition to assisting weight loss goals, resveratrol can help to prevent heart disease, stroke and diabetes.
Resveratrol Can Inhibit Brain Deterioration
One of the most important functions attributed to resveratrol is the activation of the anti-aging gene known as SIRT1. Previously, calorie restriction was the only known mechanism thought to positively influence this critical gene, but recent research demonstrates that resveratrol is also able to accomplish this longevity function. Since resveratrol is able to cross the blood-brain barrier, it is able to improve brain plasticity by generating new neural networks.
Resveratrol has been shown to reduce the normal rate of neurodegeneration while preventing memory impairment. Further, resveratrol has been shown to increase brain oxygenation which relates to increased memory capacity and improved cognition. Researchers are exploring the possibility that this amazing nutrient may play a role in the prevention of certain dementia, including Alzheimers disease.
Resveratrol helps with Weight Loss
Resveratrol has been shown to halt the formation of baby fat cells, thus providing an effective tool for the millions of people looking for a natural weight loss aide. Researchers demonstrated that fat cells make SIRT1 in direct proportion to the amount of resveratrol they are exposed to. SIRT1 halts the formation of immature fat cells which as they grow, contribute to the accumulation of dangerous abdominal fat.
Resveratrol also lowers levels of systemic inflammation which is implicated in many afflictions including heart disease, diabetes, cancer and Alzheimers, and inhibits the release of body fat from storage. Studies underscore the importance of resveratrol as an important tool in the fight against obesity, and show that it can provide favorable metabolic stability to assist weight loss.
Its rare when one specific nutritional compound is attributed with the potential to lower the risk of multiple disease processes and assist weight loss. Resveratrol continues to fill the promise of cardiovascular and neurological health as it directly influences the anti-aging SIRT1 gene, and provides support in the battle against obesity. Health conscious individuals will use this critical nutrient in a never ending battle to provide an edge against time, aging and cellular deterioration.
108. Resveratrol Resveratrol boosts blood movement to your brain
The effective antioxidant resveratrol is also recognized to encourage vasodilation, or the widening of the blood vessel which will boost blood movement. Not too long ago, a group from Northumbria University in UK published a report of their study on how the orally taken resveratrol would affect the human mental faculties, previous studies have mostly been carried out on rodents.
Their research concentrated on two areas the effect of resveratrol on cognitive performance, and the variation of blood stream to the mental faculties.
They gave each a group of 22 adults a placebos or a dose of trans-resveratrol(250 or 500 mg) in counterbalanced order on separate days. Following 45 minutes resting absorption period, the participants had to carry out a selection of cognitive duties. These tasks would activate the frontal cortex, i.e., portion of the mind that handles the larger level thinking, planning, and objective formulation.
By monitoring the total concentration of hemoglobin, they identified that there was a dose-dependent increased in blood stream to the mental faculties. Furthermore, the increase in deoxygenated hemoglobin following each doses of resveratrol suggested the presence of enhanced oxygen extraction. They then concluded that getting resveratrol did not impact the cognitive function. However, it could modulate the blood movement in the single doses of orally administered resveratrol.
The study group was small however accuracy of results were tested for consistency by using randomized, double-blind, and placebo-controlled to guard against placebo results or experimenter bias and It was a crossover study simply to compare the final results of two remedies on the identical group of patients.
The benefit from this research, can be better understood when you consider what Dr. Rosenfeld mentioned lately on his Sunday Housecall show on Fox News
For many years, hospital information revealed that more than 2 million visits to the hospital emergency room in the USA are the result of falls every single year, and the percentage of falls increases with age. Dr. Rosenfeld also added the chance of dying is much higher after one of these falls. Then he pointed out that the reduction of blood flow to the brain as a single of the factors that causes falls in the aged.
The doctor mentioned the final results of a UK research, that taking resveratrol every day will enhance blood movement to the mental faculties of the elderly. That in turn will help reduce the chance of falls.
Dr. Rosenfeld has mention before on his program that he is a regular user of resveratrol
109. Resveratrol Resveratrol antioxidant and brain disease
It is believed that oxidative damage to brain cells may be part of the process that leads to both Alzheimers disease and Mild Cognitive Impairment (MCI), so using Antioxidants to Prevent MCI and Alzheimers Disease makes sense. Antioxidant supplements such as resveratrol could be important weapons in the war on these forms of dementia that lead to cognitive and memory changes. One early study that examined 442 elderly patients in Basel, Switzerland, found a direct correlation between the blood levels of two common antioxidants (beta-carotene and vitamin C) and memory retention.9 Another study reported on the reduced risk of Alzheimers in people who took antioxidant supplements. The results of the study should come as no surprise, and unequivocally showed that, in the authors own words, use of vitamin E and vitamin C supplements in combination is associated with reduced prevalence and incidence of Alzheimers disease. Antioxidant supplements merit further study as agents in the primary prevention of Alzheimers disease. What we are learning, however, is that traditional antioxidants like alpha-tocopherol vitamin E may not be enough to protect neurons against free radicals in the long run.
Resveratrola Natural Antioxidant Vital for Preventing MCI
A useful antioxidant in preventing MCI and Alzheimers disease may be found in an age-old drinkred wine. Resveratrol is a poly-phenol found primarily in the skin of grapes, and it is present in significant amounts in red wine.
Multiple studies demonstrate the significant beneficial effect that resveratrol has in protecting brain cells from the ravages of free radicals. One published study examined the protective effect of black grape skin extracts (which are high in resveratrol) on cellular toxicity produced by the beta-amyloid peptide in human endothelial cells. The researchers showed, that, at least in the laboratory setting, the grape skin extract reduced free-radical production by beta-amyloid (a pathological protein often found in the brains of Alzheimers patients), along with protecting the epithelial cells membranes against free-radical induced damage.
Two other studies have lent credence to the idea that resveratrol can provide protection against Alzheimers disease and MCI through its antioxidant activity. One study examined the effects of resveratrol on human neuroblastoma cells subjected to oxidative stress generated from damaging beta-amyloid peptide.Resveratrol was effective in restoring glutathione (an intracellular free-radical scavenger) levels in the human cells that were subjected to beta-amyloid. Another published study showed that resveratrol protected cultured rat cells against beta-amyloid-induced cytotoxicity and intracellular accumulation of free radicals.
Are You At Risk for MCI?
One of the most serious and debilitating illnesses facing aging adults is Alzheimers disease. Alzheimers leads to progressive and irreversible memory loss and dementia.
Medical science is increasingly recognizing a milder form of memory loss termed mild Cognitive impairment (MCI). Individuals with MCI show decline in memory function when compared with healthy patients of the same age.
People with MCI face a slightly higher risk of developing Alzheimers; aggressive prevention strategies are therefore warranted to help avert both these ominous conditions.
Antioxidant-boosting nutrients such as , resveratrol and glutathione show promise in offsetting the pathological changes associated with MCI and Alzheimers.
The wine is not only of truth, as said the ancient Romans, but also a wide range of phytochemicals, especially polyphenols such as resveratrol, which are potent antioxidants. Their positive effect on our health is now little doubt and the organic wines contain more of it than the conventionally grown.
The days when you could only enjoy wine simply to experience a sensory adventure, if you had a new born or an unknown location on the tongue trickle, are over. Today is expected of us that we wine, especially red wine, to drink the healths sake. He has proved to be a medicine that protects against heart attacks, thrombosis, cancer and arteriosclerosis, dental caries and gum disease bacteria defuses prevent or so it confirms a number of scientific studies. What enables him to these services should be one of its ingredients: a true wonder drug called resveratrol.
Resveratrol a miracle cure?
Resveratrol eliminate the negative effects of overweight and fat diet (in laboratory mice), it extends the life span (from brewers yeast, fruit flies, nematode worms and fish), it kills cancer cells () in vitro, it protects the heart and blood vessels, inhibits inflammation and produces a neuroprotective effect in the brain () of rats, it was described as multi-purpose biological weapon, and an American publication called it the Swiss Army knife of nature.
Antioxidants Savior from free radicals?
Based on the amazing abilities of resveratrol is its antioxidant potency, it has a high redox potential, thus making the evil free radicals innocuous, are today blamed for a variety of diseases. Free radicals are atoms or molecules that lack an electron in their chemical structure. This steal it from other molecules, then, can now also be radical electron predators and thus trigger a chain reaction to change in the number of electrons and their owners at the end of nucleic acids, proteins or lipids are changed so much that they do not are more able to properly fulfill their biological functions. Significant for us are mainly the oxygen radicals, which are scientifically known as reactive oxygen compounds (ROS reactive oxygen species). They arise in all oxygen-dependent creatures as by-products of metabolism in the gut (for example, during processing) of alcohol and in the mitochondria, the energy plants of cells. The largest part of ROS is reduced in the course of the metabolic processes of water, the rest that remains is made by so-called antioxidants or free radicals harmless. They are firstly, the bodys own enzymes such Superoxydismutase or Glutathionperoxydase, on the other substances that we absorb with our food: vitamins A, C and E, Coenzyme Q 10 and phytochemicals, especially the carotenoids, like lycopene in tomatoes and the beta-carotene in the carrots, and polyphenols, among which is the acclaimed resveratrol.
In recent years the free radicals the very name alone evokes Civil fears were in the media insidious enemies and evil enemies stylized intended to be jointly responsible for numerous diseases including: cardiovascular diseases, cancer of lung, cervical, skin, esophagus, stomach, colon and prostate, as well as cataracts, aging and Alzheimers. The antioxidants, however, were highly praised the heroic rescuers and mass-marketed as a dietary supplement. Meanwhile, the mood changed a bit, and the miraculous effects of free radicals was relative. At least in the isolated high-dose antioxidants and several studies have found no or even a negative effect. In Finnish smokers who took vitamin E and beta-carotene, cancer mortality was higher than in the control group. A study of the men got in vitamin E and selenium to prevent prostate cancer, was canceled because it turned an increased risk of cancer.
Dietary supplements or natural foods?
Whether and how far isolated antioxidants as dietary supplements are generally useful, is currently being debated scientific controversy. Berneis Kaspar, head of the Department of Endocrinology and Diabetology, University Hospital Zurich, for example, says: For healthy people, these resources are not of allocated benefits. And he stressed that no one who eats healthy and sound, are inadequate intake of provide antioxidants to need.
In a healthy person who moves sufficient to ensure a regular basis for relaxation and fully satisfying Mediterranean-fed, there is a balance between free radicals and the endogenous or dietary antioxidants. Our body gets only be in danger if an excess of free radicals is present and is usually the result of the unhealthy and unnatural way of life. Cigarette smoke, alcohol, drugs, air pollutants (car exhaust fumes, ozone), radiation (UV, electromagnetic pollution), physical and emotional overload (stress) all these are factors that could push the number of free radicals in the air. Added to the usual diet now comes with too much meat and not enough fresh fruit and vegetables. The latter could, with their natural antioxidants, vitamins and phytochemicals, this could make a settlement.
White blood cells and red wine
An as yet neglected role in this context, certainly the so-called Verdauungsleukozytose. Already in the middle of the 19th Century was discovered by Virchow and others that, immediately after a meal, the number of white blood cells, especially granulocytes, a dramatic increase according to more recent human medical studies, approximately 50 to 140 percent. The Swiss physician Dr. Paul Kouchakoff came through his research in the 1930s to the conclusion that this must act in order to be a reaction of the body, especially against foreign proteins. He also found out that this response was absent when raw vegetable diet is consumed, or in the preparation of food, a critical temperature will not exceed approximately 87 to 97 degrees. While cooking, baking, frying and deep frying them, however, is almost always above that limit. In their defense reaction, the granulocytes produce a large amount of free radicals in order to kill invading pathogens. This is a meaningful and useful strategy if it is, for example by bacteria. But when its all about food substances, as in the Verdauungsleukozytose, then are not many free radicals useful, but become a problem to be resolved by free radicals must. The more natural antioxidants, in the form of vitamins and phytochemicals, so we start with our food, the better.
And here comes again the red wine into the game, and a phenomenon that has been called French paradox. Namely the fact that in France, especially in the south of the countrys heart attack rate is around 30 to 40 percent lower than in comparable European countries and the United States. As an explanation for the red wine consumed by the industrious Frenchman was used, and that it contains resveratrol, which is to develop a cardioprotective effect.
But critics complained that the amazing effects of resveratrol was achieved only in vitro and in experimental animals in the laboratory similar studies in humans but outstanding. In addition, a glass of red wine contains only about 0.3 percent of Resveratrolmenge, which was administered to laboratory mice in the experiment.
Nevertheless, even in low-dose resveratrol is a potent free radical, and above all, it is not alone.
Diversity of polyphenols
Red wine contains a wide range of polyphenols, which also help too, as an experienced team, each other in their effect. Two major groups are important here: the Stilbenoide and flavonoids. The former includes Astringin and resveratrol and its metabolites Viniferin, Piceid and Piceatannol, which is said to have even a thousand times more antioxidant potency than resveratrol itself, and at least pointed in the laboratory experiment a cancer-inhibiting effect. They all also appear as a cis / trans isomers. They are variants that have the same chemical formula different spatial structures. The flavonoids are plant pigments such as Fisetin that (at least in laboratory mice) promotes long-term memory, and anthocyanins such as malvidin and peonidin, which are responsible for the blue color of the grapes. It also still include condensed tannins, such as quercetin and catechin to this group. The latter is also available in different variants contained in green tea, and there is a primary factor for its healthy effect.
The polyphenols exert their antioxidant potency, not only as individual substances, as has been demonstrated in numerous trials, but encourage and support each other too well, resulting in additional synergistic effects. For example, quercetin and catechin exert a positive influence on the metabolism of resveratrol and thus increase its biological effect.
The polyphenols used in the form of flower pigments (anthocyanins), attracting insects, which make for effective pollination of plants. On the other hand, they are chemical defense substances against predators and pathogens such as bacteria and fungi. These so-called phytoalexins are formed by plants only in response to an attack such enemies. The less a plant pesticide protected from the outside is the more Phytoalexin they must produce their own protection. Therefore, it is no wonder that organically grown grapes and organic wines vinified it contained more polyphenols than conventionally produced. The same also holds for organically grown fruit and vegetables. A more than 10 years in the U.S. study for example, found that organically grown tomatoes 79 (!) Percent contained more quercetin than conventionally grown.
Healthy wine by naturally cultivated soils and plants
The amount of antioxidants in the wine also determines its shelf life, the more polyphenols it contains, the less sulfur to be added. Again, the organic wines have an advantage.
The secondary plant substances are moved only a few decades in the spotlight of science. The more you think about research, the more substances and the more positive effects are discovered. When red wine you have now more than 500 components found in addition to polyphenols, including proteins, sugars, acids, minerals, trace minerals and flavorings. Because it was assumed that the good substances mainly stuck in the dish was the red wine which is fermented with the skins, and contains more polyphenols, a priority, while the wine was a little short.
Meanwhile, studies have shown that the pulp of grapes an equally positive effect on rat hearts, as the shells. And it is believed that the wine has many health-promoting similar substances, such as red wine. Studies designed to prove this are in progress.
Overall, the attitude of science is still contradictory, and the recent findings are controversial. However, there is agreement that the natural antioxidants, as they are in fresh fruit and vegetables, and, ultimately, the wine, are preferable to the isolated and synthesized. Not least because they complement each other in their diversity and promote. Here, too, shows itself superior to the biodiversity of the monoculture.
Antiaging: we all want it, and most of us spend a lot of our lives pursuing it. Even if we dont of necessity need to look younger, we certainly want to look and feel our best for our entire lives. This has been difficult to do, with a lot of quack medicine stand-ins touting this or that as the true Holy Grail of a long life. However, a relatively recent discovery may just be that Holy Grail. Its called resveratrol, and its power is only start to be discovered.
What is resveratrol, and what does it do?
Studies have shown that resveratrol, which can easily be included in the diet when you buy resveratrol capsules or supplements, and/or when you eat Anti Aging Products rich foods containing resveratrol, is a super antioxidant that can improve health and treat different afflictions like skin inflammations, cardiovascular disease, and much more. Best of all, perhaps, though, it can help you feel rejuvenated and keep you looking young, too.
Resveratrol is a polyphenol, and its found in profusion in red food skins like grapes and different sorts of berries, as well as foods like peanuts. These foods have this antioxidant as defense against dissimilar types of fungal infections, bacteria, pathogens, and so on, so that they can thrive. The good thing is, when we consume these things, we get those benefits, too.
However, it can be quite hard to include antioxidant rich foods in our diets in large enough amounts to truly maximize its anti aging effects. Thats where supplementing with resveratrol when you buy resveratrol capsules (as well as eating antioxidant rich foods, of course) can really make a dissimilarity.
Resveratrol is not new
Actually, resveratrol has been around for a while, and the Japanese and Chinese have been using it since the 1800's. Weve also known of its effects indirectly by what has been called the French Paradox. That is, the French people have the lowest frequency of cardiovascular disease of developed countries, and yet they consume a high-fat, high cholesterol diet. Their secret, as has been found out, is that they consume copious amounts of red wine. And what major miracle ingredient does red wine have? You guessed it.
Thats not to say, of course, that you should simply guzzle down a bottle of red wine every night. Of course, red wine has its detriments when overly used, too, not least of which is its alcohol content. Thats why you can get the same benefits when you buy resveratrol supplements with none of the drawbacks.
Because it is such a powerful antioxidant, it can prevent heart disease and keep your cardiovascular system running smoothly. It may also help prevent cancer, boost Anti Inflammatory Products benefits, is an anti-inflammatory, and may in fact discourage infections from starting. It appears to be a nerve protectant, too.
Very low calorie diets are all the rage these daysbut not for the reasons you might think. Aside from keeping you slender, research shows that if you eat 10 to 30 percent less than the average person, you can also tack years onto your lifethat is, if you can keep up with this type of diet. For most, constant hunger pangs make drastic calorie cutbacks far too tough to maintain over the long haul.
But what if you could get all of the health benefits of caloric restrictionwithout the grueling dietary demands? It may sound impossible, but recent research on a unique natural compound suggests that you can have your cake and eat it too.
Resveratrola phytonutrient commonly found in the skin of red grapeshas attracted widespread attention for its astounding ability to put the brakes on aging. Its effects on longevity in mammals was first investigated back in 2006, when scientists discovered that resveratrol supplementation can inhibit complications of obesityincluding enlarged liver, muscle inflammation, and early signs of heart disease and diabetes in overfed mice.
Soon after, another study added more steam to the theorythis time showing that large amounts of resveratrol could double physical endurance (including oxygen consumption efficiency and grip strength) in healthy young mice. As a result, excess calories were more readily burned off and weight gain was prevented.
Scientists still arent sure how to account for these incredible benefitsbut they think its because resveratrol is able to mimic the effects of caloric restriction (CR) by switching on the longevity gene called SIRT1. Mice with higher levels of SIRT1 (due to genetic alterations or resveratrol consumption) show greater energy expenditure, reduced weight gain, and increased insulin sensitivityall in spite of a high-fat, high-calorie diet. And those arent the only benefits that resveratrol and caloric restriction have in common.
In a study performed just last year, researchers found that while mice with high-calorie diets lived longer while taking resveratrol, mice in the standard diet group also benefited from resveratrol supplementationshowing improved heart function and bone density, better motor function, and delayed cataracts.5 Its effects on heart health are particularly pronounced, with even more recent studies revealing that resveratrol mimics the effects of caloric restriction, and can inhibit cardiac aging by 90 percent.
References:
Baur JA, Pearson KJ, Price NL, et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature. 2006 Nov 16;444(7117):337-342.
Lagouge M, Argmann C, Gerhart-Hines Z, et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell. 2006 Dec 15;127(6):1109-1122.
Pfluger PT, Herranz D, Velasco-Miguel S, Serrano M, Tschöp MH. Sirt1 protects against high-fat diet-induced metabolic damage. Proc Natl Acad Sci USA. 2008;105(28):9793-9798.
Sun C, Zhang F, Ge X, et al. SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B. Cell Metab 2007;6:307-319.
Wikipedia says the following:Resveratrol is a phytoalexin produced naturally by several plants when under attack by pathogens such as bacteria or fungi. Resveratrol has also been produced by chemical synthesis[1] and is sold as a nutritional supplement derived primarily from Japanese knotweed. In mouse and rat experiments, anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects of resveratrol have been reported.
Scientists believe that high red wine consumption in France may be the primary reason for their longevity. Resveratrol, a compound found in the skins of grapes is the ingredient in red wine that has been linked with multiple health benefits to provide support for a healthy cardiovascular system, help maintain the normal function of the brain and promote overall good health and wellness.
Resveratrol is a powerful antioxidant that is produced by some plants such as Japanese Knot weed to protect against environmental stresses. Perhaps the most notable producer of resveratrol is the grapevine, which produces large amounts of resveratrol in the skins of grapes to protect against fungal diseases and sun damage. It is therefore no surprise that wine (in particular red wine which is fermented with grape skins) has some of the highest levels of resveratrol out of any natural food.
While it has been know for thousands of years that wine is a healthful drink (thus the old Roman saying In Vino Sanitas- In wine there is health), the scientific community started taking wines health benefits seriously after 60 Minutes reported the famous French Paradox study in which people in France were less likely to die of heart attacks than Americans despite similar high fat diets. The study concluded that the relatively large amounts of red wine consumed by the French protected their hearts.
From the French Paradox study numerous other studies were launched to attempt to identify compounds responsible for red wines apparent health benefits. From these studies the compound that gained by far the largest amount of interest was Resveratrol and other studies have concluded that:
Adding resveratrol to the diet of yeast, fruit flies, worms, and a species of fish increased their life spans up to 70%, 29%, 24%, & 50% respectively.
Resveratrol made fat related deaths drop 31% in obese mice. The resveratrol fed obese mice also performed much better in movement and agility tests than obese mice not fed resveratrol.
Mice fed resveratrol had 100% more endurance than mice not fed resveratrol (i.e. they were able to run twice as far on a treadmill).
Resveratrol inhibits blood platelet aggregation that can lead to dangerous clots that can cause heart attacks and strokes.
Resveratrol is a powerful antioxidant that can help prevent cell damage caused by free radicals (free radicals are unstable atoms caused in part by pollution, sunlight, and our bodies natural burning of fat that can lead to cancer, aging, and brain degeneration)
Resveratrol has been proven to fight cancer in vitro at all three stages; (1) initiation, (2) promotion, (&) progression.
In my continued quest for discovering how effective resveratrol can be for human health I have found the following information:-
Zhejiang University researchers in China found that resveratrol (compound found in red wine, grapes, grape juice, some berries, and peanuts) can significantly reduce blood pressure, heart rate, and renal sympathetic nerve activity, which implies that it could have a useful role in anti-aging therapy. In another study, the researchers found that resveratrol inhibits the accumulation of blood clots (which can cause a heart attack).
The Journal of Agriculture and Food Chemistry published a research that found that resveratrol selectively targets malignant (cancerous) cells and destroys them while allowing healthy cells to adjust. This is different to what happens in chemotherapy, where it kills cancerous cells but is also toxic to healthy cells.
The Apoptosis journal published findings that resveratrol and quercetin are able to prevent adeoxycholate from killing cells and causing disease. The findings show that resveratrol may help reverse the cell damage that causes colon cancer.
The Experimental Gerontology published research that found resveratrol can imitate calorie restriction by controlling mitochondrial biogenesis and turnover, critical factors in the maintenance of energy production, the prevention of endogenous oxidative stress, and the promotion of healthy aging.
Resvertarol is commonly found in Red wine (Muscadine grapes), Japanese Knot wood root, elderberry and purple carrots
Daily intakes of resveratrol a compound from red wine may improve the metabolic profile of people with obesity, according to a new study from Denmark.
Writing in the International Journal of Obesity, researchers from Aarhus University report that resveratrol changed the production of certain compounds called adipokines from human fat cells, and produced an anti-inflammatory effect.
The study is reported to be the first to in vitro suggest resveratrol has anti-inflammatory effects on adipokine expression and secretion in human fat tissue.
Small interfering molecules such as resveratrol are in this matter hypothesized to possess beneficial effects and might improve the metabolic profile in human obesity, wrote the researchers, before adding that the results need to be replicated in vivo.
The Future of Resveratrol
Resveratrol, a powerful polyphenol and anti-fungal chemical, is often touted as the bioactive compound in grapes and red wine, and has particularly been associated with the so-called 'French Paradox'. The phrase, coined in 1992 by Dr Serge Renaud from Bordeaux University, describes the low incidence of heart disease and obesity among the French, despite their relatively high-fat diet and levels of wine consumption.
Interest in resveratrol exploded in 2003 when research from David Sinclair and his team from Harvard reported that resveratrol was able to increase the life span of yeast cells. The research, published in Nature, was greeted with international media fanfare and ignited flames of hope for an anti-aging pill.
According to Sinclairs findings, resveratrol could activate a gene called sirtuin1 (Sirt1 the yeast equivalent was Sir2), which is also activated during calorie restriction in various species, including monkeys.
Since then studies in nematode worms, fruit flies, fish, and mice have linked resveratrol to longer lives. Other studies with only resveratrol have reported anti-cancer effects, anti-inflammatory effects, cardiovascular benefits, anti-diabetes potential, energy endurance enhancement, and protection against Alzheimers.
Metabolic syndrome
The new study sought to investigate if the compounds anti-inflammatory benefits extended to the low-grade inflammatory state associated with obesity. This is characterized by abnormal levels of circulating pro inflammatory factors and an abnormal production of bioactive factors/adipcytokines from the adipose tissue, explained the researchers, and these adipocytokines are suggested to have direct implications for the development of the metabolic syndrome.
116. Resveratrol Resveratrol provides more energy and controls obesity
Researchers at the Institute of Genetics and Molecular and Cellular Biology in Illkirch, France have found that resveratrol boosts the exercise capacity of muscles in mice and protects against diet-induced insulin resistance and obesity. The research was published online on November 16, 2006 in the journal Cell.
Johan Auwerx and colleagues gave mice 200 or 400 milligrams per kilogram resveratrol daily combined with a high fat diet or regular food diet for fifteen weeks. Mice who received food combined with resveratrol tended to gain less weight than animals who did not receive the compound. Predictably, mice who received the high fat diet gained significantly more weight than mice on the regular food, yet those who received resveratrol weighed almost the same as mice on the un supplemented diet over the course of the study.
The researchers determined that the decrease in weight was due to a reduction in body fat, with resveratrol-fed mice having smaller fat cells than those who did not receive it. This finding was not due to a decrease in food intake, as all mice on the high fat diet were found to have consumed a similar amount of calories per day, and had similar fecal lipid content. It was discovered that animals who received resveratrol had greater energy expenditure, with enhanced mitochondrial activity in brown adipose tissue and muscle. In an endurance test, mice who received resveratrol were able to run twice the distance that untreated mice ran before experiencing exhaustion. Similar results were obtained for endurance tests conducted with the groups who were fed the chow diets, showing that the significant difference in weight among the high-fat diet groups was not a factor in the increased resistance to muscle fatigue experienced by resveratrol-fed mice.
Although fasting glucose levels were not affected by resveratrol administration, mice that received the compound had significantly reduced fasting insulin levels, indicating improved insulin sensitivity. In another experiment with genetically obese mice on high fat diets, resveratrol improved glucose tolerance and fasting glucose levels without affecting weight, which suggests that resveratrols antidiabetic effects may be independent of its effects on body weight.
In agreement with previous research, the team concluded that resveratrol increases the activity of the gene Sirt1, which has been associated with increased life span. In an experiment with humans, they demonstrated an association between genetic variation in the Sirt1 gene and whole body energy expenditure.
This work is significant because it shows that a SIRT1 activator can protect against metabolic disease, highlighting the therapeutic potential of sirtuins, Dr Auwerx stated. Resveratrol, a compound found in the skin of red grapes and hence in red wine, could very well explain the French Paradox.
Dr. Whitaker has an article in the September 2010 issue of Health & Healing; it is basically a synopsis of the many studies of this remarkable nutrient. Since 2006, there have been more than 3,400 peer-reviewed journal articles published on this compound, and, although most involve rodent models of human disease, resveratrols therapeutic potential seems to be the real deal.
Resveratrol is a naturally compound that is concentrated in the skin of red grapes, cranberries, blueberries, peanuts and dark chocolate. Resveratrol effects a class of enzymes that play critical roles in DNA repair, maintain genome stability, protect against oxidative stress, and reduce inflammation. Long story short: these enzymes increase cell suResveratrolival. Resveratrol works on the same enzymes that caloric restriction does, and it probably will be more practical, since asking humans to cut calories by a third may be a pipe dream.
Resveratrol has been shown to reduce the risk of cataracts, kidney dysfunction, and inflammatory bowel disease. Sound too good to be true? Keep reading. Resveratrol helps prevent strokes and heart attacks, strengthens bones, improves lung function. It also protects against neurodegenerative disorders such as Alzheimers and Parkinsons, and improves memory, learning, and brain plasticity. Resveratrol also seems capable of increasing insulin sensitivity, enhance fat-burning, and relax arterial walls, thereby combating the big three threats to public health: type 2 diabetes, obesity, and heart disease.
Best of all, there are no reported side effects. The Chinese have used it in their medicine cabinet for years; they call it hu zhang and it comes from the root of Japanese Knotweed, they have used it to treat a variety of ailments.
Best results occur if you start taking it early in life (by age 40), but good results have also been documented at 60 years of age. Recommended dosage is 100-250 mg per day. Dr Whitaker says to look for a standardized extract of trans-resveratrol such as ResVinol-25.
Resveratrol is currently one of the most research plant derived nutrient compounds. Studies are focusing not only on resveratrols role in serving plants and animals survive under stress, but also on its potential to improve human health and longevity. Animal studies have already shown that a diet containing resveratrol can expand life span.Cell culture and animal studies have also demonstrated other settlement of resveratrol. They include: supporting cardiovascular health, inhibiting cancer growth , activating detoxification and antioxidant genes, improving insulin sensitivity, increasing the number of mitochondria and their energy-producing efficiency, even activating an enzyme that promotes cellular repair.
Resveratrol Sources
A naturally occurring compound produced by and isolated from a variety of plants. extremely concentrated in and commonly extracted from the root of the Japanese Knotweed . Resveratrol is also available from red-grape skins, cranberries and peanuts. chance of more potent synthetic forms.
Benefits of Resveratrol
In studies with yeast cells, fruit flies and rodents, mimics the life-extending effects of caloric restriction, including improving blood pressure, cholesterol level and cardiovascular health, as well as decreasing inflammation . Believed to help breakdown fat for energy, promote normal blood sugar and bone strength, and keep DNA. Resveratrol may also promote energy balance and disease resistance.At the cellular level, it is shown to activate the SIRT1 enzyme which encourages self-repair. Also believed to increase the number of mitochondria and improve energy creation .
Resveratrol Research
Until recently , primarily animal and cell culture studies. almost no negative side effects observed, even at very high doses. Several studies published, demonstrating the effects of resveratrol on animal metabolism and longevity . Fed an unhealthy diet high in fat, mice developed diabetes and heart disease, were lethargic and had shorter life spans. Fed the high-fat diet supplemented by resveratrol, mice were as healthy and lived as long as those fed a healthy diet.
Resveratrol, is one of the main antioxidants found in wine. It is a phenolic bioflavonoid compound which acts as an anti - fungal agent in grapes, especially during ripening. It also naturally occurs in Japanese knot weed , chocolate and peanuts..
One of the main functions of antioxidants is to inhibit low density lipoprotein(LDL) or bad cholesterol from entering blood vessel walls and forming antheromatous plaques which eventually block off arteries causing vascular diseases such as heart attack and stroke.
The other main function of antioxidants is to inhibit the action of free radicals which are negatively charged rogue molecules (with one unpaired electron in their orbit). The body is continuously producing waste products from its many complex bio chemical pathways. These waste products include free radicals which become free agents causing biochemical havoc leading to such things as body degeneration, aging and cancer.
Resveratrol stimulates Mapkinase.
Research into resveratrol is showing that it has other benefits besides its antioxidant role in reducing vascular disease and cancer for example. Scientists at The University of Milan under Alberto Bertelli have shown that resveratrol stimulates Mapkinase, their paper having been published in The New Scientist on the 9th January 1999. MapKinase stands for mitogen-activated-protein kinase which is a proactive enzyme cascade forming one of the main intracellular signalling pathways stimulated by upstream activators such as resveratrol. As such, Mapkinase cascades are very important intracellular signal transducer pathways playing a vital role in cell proliferation, differentiation and transformation.In the nervous system Mapkinase stimulates nerve cells and helps them regenerate by up to sevenfold.
Researchers found that resveratrol made the human neural cells grow extensions which enabled them to connect to neighbouring nerve cells. This helps explain why wine drinkers have less of the neuro-degenerative diseases such as Alzheimer's disease (commonest form of dementia) and Parkinson's disease due to the resveratrol in the wine helping the nerve cells in the brain grow and connect. In neurodegenerative diseases, these connections break down. "By daily re enforcing these contacts we can prevent neurodegeneration" Dr Bertelli has stated.
Professor Jean-Marc Orgogozo, head of Neurology at The University Hospital of Bordeaux and a member of AIM's Editorial Board, published a paper entitled "Wine consumption and dementia in the elderly: a prospective community study in the Bordeaux area".Rev Neurol (Paris) 1997 April 153(3): 185-92 which similarly shows that moderate wine consumers are less likely to develop neuro-degenerative diseases.
Consumption of resveratrol would also mean that the vascular tree within the brain would be less diseased, hence able to supply the brain's nerves with more blood containing essential oxygen and glucose. This is another mechanism by which resveratrol helps the brain function better.
There are certain plants that have the ability to manufacture phtoloalexin in order to defend themselves from fungi and bacteria. Phtoloalexin is a substance that is known as resveratrol, which has numerous health benefits to humans.
This amazing compound can be easily categorised and there are a lot of sources in which you can found resveratrol such as raspberries, grapes, cranberries, mulberries and blueberries just to name a few. The substance can also be found in certain everyday snacks such as peanuts. All these food sources are rich in antioxidants and since they also have anti-coagulating effects that can help reduce the risk of heart disease, a lot of people believe that resveratrol compound has the same beneficial effects.
Anti-aging properties found in resveratrol can effectively replace dead cells and maintains their freshness and good health. With the bad quality of the environment, oxidation is possible and may cause damage to the skin cells and it is important to replace these dead skin cells in order to keep the skin radiant looking.
Nowadays, many people live a busy lifestyle and this causes most individuals to take shortcuts in terms of nutrition, eating, sleep and other activities in general. One of the possible solutions to maintain good health is by taking a well-balanced supplement. According to experts, a supplement with resveratrol compound can greatly help in providing the body strength and protection against numerous diseases.
Resveratrol contains high antioxidant content, which is up to fifty times stronger than most fruits. Resveratrol helps battle cellular damage, which makes it one of the most beneficial compounds to health. Recent studies show that the compound is effective in fighting illnesses and it can also aid in extending your life span.
Resveratrol can effectively help the body increase muscle mass and lessen fat cells. Furthermore, it acts as an appetite suppressant, making it a natural option for individuals who want to lose or control weight. It is also important to note that resveratrol does not only help the body repair cellular damage but it also helps inhibit further damage and defend the body from certain serious illnesses such as cancer.
Resveratrol can also protect the heart and the cardiovascular system. It helps in the reduction of oxidation of bad cholesterol or LDL inside the body. This is very important in fighting artery blockage and heart disease.
Resveratrol dietary supplement capsules have been becoming increasingly popular since they were reported on 60 minutes in January 2009. Why have they become so sought after and what can they do for you?
Resveratrol is a polyphenol antioxidant that comes from grapes, peanuts, berries and cocoa beans. Most of the resveratrol dietary supplements that are made today come from the Japanese Knotweed. They have been used in Japan and China for several decades as a treatment for a wide range of conditions such as heart and liver diseases, inflammation, lethargy, infections and for weight loss.
Today, scientists have been researching resveratrol extensively and have found that it can benefit our health in many ways that were never even considered.
Resveratrol dietary supplement is probably most commonly known for its anti aging properties. They do this by an attack on more than one front.
1. It activates longevity genes called sirtuins. Sirtuins help protect our cells from deterioration and also helps with restoring damaged cells.
2. The antioxidant prevents the formation of free radicals that damage our cells and also kills free radicals that do develop.
Another way that resveratrol dietary supplements can benefit our health is by reducing our weight.
Those longevity genes called sirtuins can help in other ways apart from anti aging. When resveratrol activates the sirtuins, it is activating the same gene that a reduction in calories, or fasting, activates. When fasting occurs, our cells start to burn off the excess fat in our body. This burning of fat in itself uses extra energy and more weight is lost.
The other major disease that resveratrol is being researched for is cancer, in which it seems it has potential to prevent different cancers in several ways. Although these are some promising results the research is at a very early stage.
Because resveratrol dietary supplements can protect our cells and therefore prolong their life, this can have a knock on effect of protecting our bodies from many other ailments such as heart disease, neurological complaints, Alzheimers, rheumatoid arthritis and can improve energy levels, immune system and respiratory problems.
Resveratrol is a completely natural product and has a low degree of side effects. Its true potential has yet to be revealed but it certainly has made a good start.
Resveratrol is a protective bioactive nutrient found most commonly in the skin of red grapes, peanuts, Japanese knot weed and cacao. Resveratrol provides a protective barrier against disease and fungus in plants which is also beneficial to human health. A wealth of information exists to support the function of resveratrol for brain rejuvenation, cardiovascular repair as well as influencing the metabolism of fat leading to natural weight loss.
Resveratrol Can Help Prevent Heart Disease
Proanthocyanadins from the grape family have long been associated with heart health, the so called French Paradox. now resveratrol is being placed at the top of the cardiovascular friendly nutrients list. The lining of the cells within the artery are known as the endothelium, and are very sensitive to dietary abuse caused by hydrogenated fats, excess sugar, cortisol and insulin. Damage to the endothelium leads to high blood pressure as well as micro cracks which are filled with foamy plaque, increasing the risk of heart attack.
The results of a peer reviewed study published in the online journal PLoS One, resveratrol was found to be a natural anti-aging agent and exhibited many of the same characteristics as calories restriction. This natural defense nutrient is able to act at the genetic level to influence genes which promote cardiac dysfunction and glucose metabolism. In addition to assisting weight loss goals, resveratrol can help to prevent heart disease, stroke and diabetes.
Resveratrol Can Inhibit Brain Deterioration
One of the most important functions attributed to resveratrol is the activation of the anti-aging gene known as SIRT1. Previously, calorie restriction was the only known mechanism thought to positively influence this critical gene, but recent research demonstrates that resveratrol is also able to accomplish this longevity function. Since resveratrol is able to cross the blood-brain barrier, it is able to improve brain plasticity by generating new neural networks.
Resveratrol has been shown to reduce the normal rate of neurodegeneration while preventing memory impairment. Further, resveratrol has been shown to increase brain oxygenation which relates to increased memory capacity and improved cognition. Researchers are exploring the possibility that this amazing nutrient may play a role in the prevention of certain dementia, including Alzheimers disease.
Resveratrol Inhibits the Formation of Fat Cells
Resveratrol has been shown to halt the formation of baby fat cells, thus providing an effective tool for the millions of people looking for a natural weight loss aide. Researchers demonstrated that fat cells make SIRT1 in direct proportion to the amount of resveratrol they are exposed to. SIRT1 halts the formation of immature fat cells which as they grow, contribute to the accumulation of dangerous abdominal fat.
Resveratrol also lowers levels of systemic inflammation which is implicated in many afflictions including heart disease, diabetes, cancer and Alzheimers, and inhibits the release of body fat from storage. Studies underscore the importance of resveratrol as an important tool in the fight against obesity, and show that it can provide favorable metabolic stability to assist weight loss.
Its rare when one specific nutritional compound is attributed with the potential to lower the risk of multiple disease processes and assist weight loss. Resveratrol continues to fill the promise of cardiovascular and neurologic health as it directly influences the anti-aging SIRT1 gene, and provides support in the battle against obesity. Health conscious individuals will use this critical nutrient in a never ending battle to provide an edge against time, aging and cellular deterioration.
Research undertaken at the University of Connecticut has shown that resveratrol could replace aspirin as the Superior Heart Health Protector and the Best Choice for Your Healthy Heart.
It is a well known fact that many doctors recommend taking aspirin as a method of warding off heart attacks, however this only protect 8 out of 1,000 men and does not work for women.
Researchers found that resveratrol may provoke a pre-conditioning effect whereby antioxidant defenses in the heart are switched on prior to a heart attack, limiting damage to heart muscle should a heart attack occur. After inducing heart attacks in animals, University researchers found that Resveratrol significantly reduced damage to heart muscle. Scarring and fibrosis were limited and the animals survived an otherwise deadly heart attack.
Resveratrol likely fulfills the definition of a pharmacological preconditioning compound and gives hope for the therapeutic promise of alternative medicine, commented Dipak Das, PhD, ScD, MD (hon), professor and director of the Cardiovascular Research Center at the University. The dosage of Resveratrol is critical in producing the pre-conditioning effect. Researchers found the dosage of 175-350 milligrams reduced damage to the heart during a heart attack, while ten times greater dose (1750-3500mg) increased the area of damaged cardiac tissue.
Resveratrol also thins the blood and inhibits clots that form in coronary arteries in a similar fashion to aspirin. Resveratrol exhibits other beneficial properties such as inhibiting plaque from sticking to artery walls. These findings indicate that Resveratrol may be superior to aspirin in preventing heart attacks and reducing heart damage should a heart attack occur.
"Being one of the few cardiology groups in the nation to have experience with both of these preventive agents, we are in a unique position to provide consultation to patients seeking answers to questions about the best ways to prevent fatal events," says Jacqueline Hollywood MD, another cardiologist with the Advanced Cardiology Institute.
Despite some impressive results in laboratory testing, studies have suggested that many resveratrol supplements probably aren't worth investing money in. The latest research indicates that the plant-based nutrient needs to reach the bloodstream in sufficient quantities to have any significant effects, and testing has unfortunately proved that this simply doesn't happen.
Individuals have been tested under a series of different conditions, including the consumption of wine on an empty stomach, drinking it with a meal and taking resveratrol in a non-coated form. None of these tests provided an indication of significant trans-resveratrol increases in the bloodstream because you need to drink about 300 glasses to match the levels feed to laboratory mice.
Studies were also conducted with the purpose of researching the benefits of resveratrol based on standardized supplements with the highest trans-resveratrol concentration of 50%. Testing proved that when a certain coating is added to a supplement, levels of trans-resveratrol in the bloodstream do actually increase but most companies don't supply their supplements with either the coating or the specific concentration of trans-resveratrol required for this to happen.
When taking resveratrol in either a liquid or powder form, there are unlikely to be any benefits at all. Drinking red wine may provide some benefits, but this could be down to rhodium or iridium instead of trans-resveratrol content. Also, the amount an individual would have to drink to provide effective blood cell circulation could be potentially damaging to the liver.
In turn, results prove that taking resveratrol supplements may only be beneficial if suppliers use an effective concentration combined with other key nutrients and coat their product to enable it to reach the upper intestine in sufficient quantities so as to enter the bloodstream effectively.
If taken in sufficient quantities, resveratrol has a range of benefits that include a healthier heart, improved function of the body's natural metabolism and more. Resveratrol has also been shown to lower the risk of cancer, assuming these benefits can be transferred to humans following advanced animal testing.
Although nobody is completely sure how trans-resveratrol works, it is suspected that there is an increase in gene activity that can slow down the effects of superoxide. These superoxide molecules are a free radical that aren't particularly toxic but can cause DNA degeneration of an extended period of time. Gene activity actually reduces a superoxide to hydrogen peroxide which is also a free radical.
Based on this theory, resveratrol supplements should also contain Vitamin C, glutathione and enzymes to increase their benefits. This way hydrogen peroxide is further reduced to water by the Vitamin C and other ascorbates. The presence of glutathione and enzyme enable Vitamin C to stay in the body for longer.
Resveratrol is a bio active compound found in grapes and red wine. Interest in the compound began in 2003 when research showed that resveratrol was able to increase the life span of yeast cells.
Its a polyphenolic bioflavanoid antioxidant that certain plants produce in response to stress, such as injury or fungal infection. it made the headlines as a result of the tendency for French people to have great cardiovascular health despite a poor diet and love for wine (which is a rich source of resveratrol).
A later study by Harvard researchers found it could extend the life span of yeast cells. Since then it has been found to similarly extend the life span of nematode worms, fruit flies, fish, and mice. It works by activating a gene called sirtuin1, which is also activated during calorie restriction another method to extend life span in various species.
Resveratrol Helps Lower Insulin and Inflammation
One is through its ability to modify inflammation in your body. Resveratrol helps prevent your body from creating sphingosine kinase and phospholipase D two molecules known to trigger inflammation.
While inflammation is a natural bodily response (its a process in which your bodys white blood cells protect you from outside invaders such as bacteria and viruses), its possible for your body to exist in a chronically inflamed state.
Chronic inflammation is not beneficial, and in fact has been linked to numerous chronic diseases including heart disease.
Resveratrol also seems to produce many similar benefits as exercise, including lowering insulin levels, which is a key to fighting disease and staying young. Insulin resistance speed up the aging process, while keeping insulin level resistance normal has the opposite effect.
Sirtris Pharmaceuticals has, in fact, already developed a resveratrol pill that was used in a trial on people with untreated diabetes.
The results showed it lowered glucose and insulin levels without any changes in diet or taking other drugs.
Resveratrol a Potent Free Radical Scavenger
Aging is a natural process that reflects the free radical damage that accumulates in your cells over the years. When your body uses oxygen, it naturally produces free radicals that attack your cells. Even breathing produces free radicals. This means your very cells are constantly under attack from free radicals; and sooner or later, you WILL begin to experience the first signs of aging.
A diet rich in fresh, organic vegetables and fruits is one of the best ways to enhance your bodys free radical protection, but powerhouses like resveratrol may give you an extra boost.
Resveratrol deeply penetrates the center of your cells nucleus, giving your DNA time to repair free radical damage. It also supports cell functions in your heart and brain so that you can:
* Help prevent the rampant spread of cancer cells at any stage
* Keep your blood circulation going smoothly and prevent arterial damage
* Protect your brain from the development of Alzheimers disease
* Prevent neurological disorders such as strokes, ischemia, and Huntingtons disease
Should You Get Resveratrol from Red Wine?
Resveratrol is found in abundance in red wine, and its highly soluble in alcohol, meaning your body may absorb more of it from red wine than from other sources. It is not, suggested that drinking large amounts of red wine, as the alcohol is a poison to your system.
You can get some resveratrol from your diet by eating grapes (muscadine grapes have the highest concentration of resveratrol in nature because of their extra thick skins and numerous seeds where it is concentrated), cocoa, dark chocolate and peanuts, but it will likely be difficult to get a therapeutic dose, especially since these are all foods I recommend you eat only in moderation.
The other option is to take a resveratrol supplement, and in this case be sure to look for one made from a whole food complex that includes muscadine grape skin and seeds. If you are seeking more information check out this blog
Why you might ask should you buy resveratrol but with some much media coverage it there must be something behind the hype.
Millions of people have been enjoying many benefits thanks to taking Resveratrol regularly. Weight loss, younger-looking skin, and overall better health are just a few of these benefits.
Let consider three common myths associated with Resveratrol
1.Resveratrol is just another hyped up claim like Acai its all hype and no substance.
Resveratrol has been featured on many news programs like 60 Minutes, NBC Nightly News, and Fox News. It has also been talked about by Oprah, Dr. Oz, and Dr. Phil. New research studies about Resveratrol are making headline news all the time! Believe me, from a number of diverse sources
2.Resveratrol has only been proven effective in mice.
Yes most of the research so far has been conducted on mice, but you must also consider that pharmaceutical drugs are also tested on mice first. Most of the time, the results in the mice accurately reflect the results in humans. There are also thousands of people who buy Resveratrol and use it to lose weight, look younger, and improve their heart health, among many other reasons. Resveratrol works if it didnt, no one would buy it!
3.The only way to get any benefit out of Resveratrol is to drink hundreds of glasses of wine every day!
That is true if you want to get the antioxidant the natural way. But if you buy Resveratrol supplements, youll be enjoying highly concentrated amount of it so you can enjoy it to its fullest potential (without drinking yourself to death!)
People who choose to buy Resveratrol and take it on a regular basis enjoy these improvements to their health:
* Lowered cholesterol
* Anti-carcinogenic effects
* Less risk of developing diabetes
* Increased energy & endurance
* Reduced chances of heart disease
* Anti-aging effects
* Raised metabolism
If you are seeking more information check out this blog
Resveratrol was first isolated in 1940 in the root of White Hellebore and cinnamon and is used in Chinese medicine, it cancer fighting properties have been published in various studies from 2001 onwards. below is an extract from 2007.
Resveratrol, a polyphenol found in numerous plant species, including mulberries, peanuts and grapes, has shown to possess chemopreventive properties against several cancers, and cardiovascular diseases. Recently, resveratrol has been shown to have positive effects on age longevity, lipid levels and a preventative quality against certain cancers and viral infections. Resveratrol induces apoptosis by up-regulating the expression of Bax, Bak, PUMA, Noxa, Bim, p53, TRAIL, TRAIL-R1/DR4 and TRAIL-R2/DR5 and simultaneously down-regulating the expression of Bcl-2, Bcl-XL, Mcl-1 and survivin. Resveratrol causes growth arrest at G1 and G1/S phases of cell cycle by inducing the expression of CDK inhibitors p21/WAF1/CIP1 and p27/KIP1.
Resveratrol has also been shown to reduce inflammation via inhibition of prostaglandin production, cyclooxygenase-2 activity, and nuclear factor-kappaB activity. Modulation of cell signaling pathway by resveratrol explains its diverse bioactivities related with human health. Resveratrol also potentiates the apoptotic effects of cytokines, chemotherapeutic agents and gamma-radiation. Pharmacokinetic and pharmacodynamic studies demonstrated that the main target organs of resveratrol are liver and kidney, and it is metabolized by hydroxylation, glucuronidation, sulfation and hydrogenation. As a chemoprevention agent, resveratrol has been shown to inhibit tumor initiation, promotion, and progression. There is growing evidence that resveratrol can prevent or delay the onset of various cancers, heart diseases, ischemic and chemically induced injuries, pathological inflammation and viral infections. This review summarizes the molecular mechanisms of resveratrol and its clinical benefits for human diseases.
Source: Shankar S, Singh G, Srivastava RK. Chemoprevention by resveratrol: molecular mechanisms and therapeutic potential. Frontiers in Bioscience. 2007 Sep 1;12:4839-54. PMID: 17569614
128. Resveratrol Dr. Whitaker wrote an article in the September 2010 issue of Health & Healing; it is basically a synopsis of the many studies of this remarkable nutrient. Since 2006, there have been more than 3,400 peer-reviewed journal articles published on this compound, and, although most involve rodent models of human disease, resveratrols therapeutic potential seems to be the real deal.
Resveratrol is a naturally compound that is concentrated in the skin of red grapes, cranberries, blueberries, peanuts and dark chocolate. Resveratrol effects a class of enzymes that play critical roles in DNA repair, maintain genome stability, protect against oxidative stress, and reduce inflammation. Long story in short: these enzymes increase cell suresveratrolival. Resveratrol works on the same enzymes that caloric restriction does, and it probably will be more practical, since asking humans to cut calories by a third may be a pipe dream, so it can help reduce weight.
Resveratrol has been shown to reduce the risk of cataracts, kidney dysfunction, and inflammatory bowel disease. Sound too good to be true? Keep reading. Resveratrol helps prevent strokes and heart attacks, strengthens bones, improves lung function. It also protects against neurodegenerative disorders such as Alzheimers and Parkinsons, and improves memory, learning, and brain plasticity. Resveratrol also seems capable of increasing insulin sensitivity, enhance fat-burning, and relax arterial walls, thereby combating the big three threats to public health: type 2 diabetes, obesity, and heart disease.
Best of all, there are no reported side effects. The Chinese have used it in their medicine cabinet for years; they call it hu zhang, and have used it to treat a variety of ailments.
Best results occur if you start taking it early in life (by age 40), but good results have also been documented at 60 years of age. Recommended dosage is 100-250 mg per day. Dr Whitaker says to look for a standardized extract of trans-resveratrol such as ResVinol-25.
Resveratrol could be the new wonder drug and came to prominence during tests on mice as with any new drug it take time for sufficient proof to be made available with regards to human consumption.
Resveratrol And weight loss Real Facts or just Hype
After much research on the subject, I am able to certainly say that the results of clinical studies performed all around the globe are definitely looking good. While it is true that many clinical studies including those performed at the Institute of Genetics and Molecular and Cell Biology in Illkirch, France have shown this substance can indeed help speed up metabolism. Other benefits include lowering of blood sugar in diabetics, anti-cancer applications and increased heart functions all ascribed, through clinical studies to resveratrol!
Resveratrol is a natural substance, that contains phytoalexin produced naturally by certain plants when under attack by pathogens like bacteria or fungi basically a kind of fermentation. Its also found in the skin of grapes and in red wine. This implies researchers havent had time to learn all the great health benefits, and how they can apply to you and your particular needs. However how precisely can resveratrol help you lose weight?
Resveratrol Boosts Metabolism
The speed of your metabolism to a large extent determines if you are naturally fat or thin and how quickly you will lose or gain weight. If youve a naturally slower metabolism, then your body cant burn off the calories as quickly as somebody with a higher metabolism.
Resveratrol has been shown to help increase the rate of metabolism due to its unique biological make up. With a raised level of metabolism, your body can now use more calories per hour even when youre not expending much energy yourself.
While this is an admittedly subjective measurement in human terms, clinical studies have shown that mice fed this substance hadbetter treadmill endurance than those not that werent given resveratrol.
What are you able to do with this increase in your energy level? Burn more fat! The concept is very simple. If you dont have the energy to move around you probably will not get up and move around.
Resveratrol Boost Levels Of Antioxidants
Clinical studies have shown that resveratrol can fight the devastating aftermath of diabetes, cancer and Alzheimers disease. Diabetes is a specific concern among people who are tolerably to severely overweight, as their blood sugar and insulin levels are difficult to control.
As you can see, this natural health supplement could be a great overall addition for your health generally. And, combined with a reasonable diet and moderate levels of exercise, resveratrol could be a great partner to help shed weight and burn that fat.plus improve your lifestyle.
130. Resveratrol Resveratrol reduces hardening of the arteries
Atherosclerosis is reversible is not a phrase we expected to hear from mainstream medical researchers until very recentlysince these are the precise opening words of a remarkable editorial about resveratrol that appeared in an issue of the prestigious New England Journal of Medicine last year. Just as astonishingly, the editorial was written by a renowned immunologist, Linda K. Curtiss, PhD, of the Scripps Research Institute in La Jolla, California. The fact that an immunologist is writing about cardiovascular disease in a trend-setting medical journal speaks volumes about how far we have come in our understanding of chronic diseases and their relationships with inflammation, which is an immune system phenomenon. What truly sets Dr. Curtisss article apart, though, is her description of a dramatic new phenomenon mediated by the grape polyphenol resveratrol.
Curtisss excitement comes from work done by Cleveland Clinic cell biologist Young-Mi Park, MD, who was exploring the role of oxidant stress and inflammation on the pathogenesis, or disease-causing mechanisms, of atherosclerosis. Knowing that fat-laden inflammatory cells called foam-cell macrophages trigger inflammation when they become trapped beneath the lining of blood vessels, Parks team sought to understand why the cells become trapped, and how they could be freed from their endothelial bondage, thereby reversing the inflammatory process.
The most natural approach to take, Parks group decided, was simply to test known antioxidants ability to prevent the foam cells from migrating into the endothelial lining in the first place, and their ability to release any cells that were already present. Specifically, they studied how oxidized low-density lipoprotein (LDL) promotes foam-cell formation and impairs migration. To do this they blocked LDL oxidation with several potent antioxidants. They found that oxidized LDL actually triggered production of a sort of cellular glue in the form of filaments of actin, one of the proteins also found in muscle tissue. The actin filaments were entangling the foam cells, preventing their natural migration out of the endothelial lining, leading to progressive inflammatory changes.
Parks group chose resveratrol as one of the two antioxidants to testanother testimony to the respect that mainstream researchers are according this remarkable molecule (the other was N-acetylcysteine, also an antioxidant available in supplement form). Resveratrol treatment of the foam cells inhibited production of reactive oxygen species by greater than 90%, an important first step in breaking the cycle. Even more impressively, resveratrol supplements partially restored the foam cells ability to move out of the entangling actin filaments, and migrate away from the endothelial lining!
This brings us back to Dr. Curtisss astounding initial observation that atherosclerosis is a reversible conditionthrough the use of powerful antioxidants such as resveratrol, we can now understand how oxidized LDL contributes to invasion of endothelium by inflammatory cells, and how prevention or reversal of LDL oxidation promotes mobilization of inflammatory cells and their emigration away from vessel linings.
As Dr. Park concluded, [these studies] also provide additional mechanistic support for the atheroprotective effect of antioxidants. Resveratrol is already well-known as a cardiovascular protective supplementthe work of Park and others is now showing us that resveratrol must also be considered a valuable cardiovascular therapeutic supplement, one that can literally turn back the clock on chronic vascular diseases of aging!
There have been very few trials or studies conducted on humans taking resveratrol. Those that have been conducted usually are carried out on a few number of people.
One new study concluded earlier this year led by Prof. Paresh Dandonda from the University at Buffalo, suggests that resveratrol may reduce oxidative stress and inflammation through increased expression of anti-inflammatory cytokines, and a reduction in pro-inflammatory molecules.
the first time such effects have been observed
Oxidative stress and chronic inflammation are part of the root causes of many diseases such as cardiovascular diseases, insulin resistance, auto-immune diseases like rheumatoid arthritis, and Alzheimer's disease.
The new study, was published online in the Journal of Clinical Endocrinology and Metabolism, investigated the effects of resveratrol-containing Polygonum cuspidatum extract (PCE) on oxidative stress and inflammation, by measuring its suppressive effect on reactive oxygen species (ROS) generation and a range inflammatory mediators.
Inflammation and Resveratrol
The aims of the new six week study were to investigate the effect of PCE on oxidative and inflammatory stress in normal human subjects based on twenty people who either received a PCE containing 40Mg of resveratrol or a placebo.
Researchers observed that the resveratrol rich PCE suppressed reactive oxygen species generation, and also suppressed binding of the pro-inflammatory cytokine NFkB. The study also saw a significant reduction in the expression of tumor necrosis factor-alpha and interleukin-6, two major pro-inflammatory cytokines that are regulated by NFkB.
In parallel to these effects, the study witnessed a reduction in the expression of two major pro-inflammatory molecules (JNK-1 and IKK?), leading to an anti-inflammatory response. The study also saw a reduction in the expression of SOCS-3, a protein that is modulated by pro-inflammatory cytokines.
The observations suggest a potent anti-inflammatory effect of PCE containing resveratrol.
Prof. Dandona said that whilst the results of the study are promising, one drawback is that the research did not eliminate the possibility that something other than resveratrol was responsible for the observed anti-inflammatory response from PCE.
Resveratrol and Diabetes
An early pilot study by Investigators from Albert Einstein College of Medicines Diabetes Clinical Trials Unit used ten people to conclude that at moderate doses of resveratrol improved insulin resistance and lowered post-meal glucose levels in patients with IGT, a promising result for people with type 2 diabetes or at high risk for this condition. These results were considered sufficiently important for presentation to researchers assembled at the American Diabetes Associations Annual Scientific Meeting .
The results of this pilot study are preliminary and need to be confirmed in larger numbers of patients, said Jill Crandall, M.D., Associate Professor of clinical medicine at Albert Einstein College of Medicine and lead investigator of the study. However, we are encouraged by these findings and plan to conduct additional studies to further explore the potential utility of resveratrol in improving glucose metabolism.
Over the past few years there has been much consumer interest in Resveratrol which has been featured on 60 minutes demonstrating how red wine might be be good for you. Resveratrol is a compound found in certain grapes, chocolate and Japanese knot weed. Is this the elixir of life?
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132. Resveratrol Japanese knot weed may be one of the worlds top 100 invasive weeds, whose roots can undermine walls and buildings but it is also is a major source of Resveratrol which has life enhancing properties. It has been used for many years in Chinese medicine where it is known as Hu Zhang root extract. The weed can be eaten in raw and cooked form, so if it invades your garden you might consider adding it to your diet.
Resveratrol drew public attention manly its link to red wine as a product that can extend life an appeared on many TV programs such as News Night and 60 Minutes.
Resveratrol is a powerful antioxidant that is able to slow down the aging process and even reverse signs of aging. It is also powerful in reducing the incidence of diseases related to age such as heart disease, diabetes, cancer, and Alzheimer. And yes, it reduces fine lines and wrinkles too.
It has wider applications as resveratrol also has very potent weight loss properties too. In fact this property is very effectively highlighted in the form obtained from nuts. Although this source of the compound is itself considered to be very unhealthy due to the fact that it contributes considerably to the cholesterol content of the body, test results showed that people who were on a diet containing such nuts had much less percentage of body fat as compared to those who were on a normal diet.
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Resveratrol continues to be the subject of much attention as a supplement. Its a stilbene derivative and a phytoalexin (antibiotic produced in plants). It has been identified in more than 70 species of plants but is abundant in grapes (the skin)and Japanese Knotweed is also a potent resource of the supplement. It is present in grape peels and peanut as well. However, the product only became visible on shelves following bulletins stating publicly that it was the substance in red wine that was responsible for the well-being advantages of the drink.
Resveratrol studies using yeast, worms, flies and mice show that they increase the life span, it is tool early to confirm its effects on humans but might explain why French wine drinkers appear to be healthier.
A Resveratrol study on mice showed it increased the life span of mice on a high-fat diet compared with life span of mice on a normal diet, interesting it did improve the life span of mice fed a normal diet. Mice on resveratrol had lower blood glucose levels due to increased insulin resistance.
One side effect of Resveratrol, if you are taking large amounts is diarrhea which could cause dehydration and may effect the kidneys
Below is an extract from a study of mice undertaken in Singapore in 2008 and subsequently published in Free Radical Biology and Medicine, Volume 46, Issue 6, 15 March 2009, Pages 799-809
Yee Ting Wong, Jan Gruber, Andrew M. Jenner, Mary Pei-Ern Ng, Runsheng Ruan and Francis Eng Hock Tay
Resveratrol, a naturally occurring phytoalexin that can be found in red wine, berries, and peanuts, has been shown to extend both mean and maximum life span in model organisms. resveratrol has also been reported to shift the physiology of middle-aged mice on a high-calorie diet toward that of mice on a standard diet. These beneficial effects of resveratrol have been suggested to resemble caloric restriction. Our study in F2 four-way cross-hybrid mice was the first to evaluate the effects of aging and long-term resveratrol treatment (14.09 ± 3.4 mg/L in drinking water for 6 or 12 months) on biomarkers of oxidative damage to DNA, 8-hydroxy-2?-deoxyguanosine (8OHdG); lipid, 8-iso-prostaglandin2? (8-iso-PGF2?); and protein, protein carbonyl content (PCC). There was a significant age-dependent accumulation of oxidative damage to DNA, lipid, and protein as well as a clear increase in urine 8-iso-PGF2? levels in the majority of mouse tissues. Rates of age-dependent increases in damage biomarkers varied between tissues. Chronic resveratrol treatment elevated total resveratrol plasma levels and reduced the observed age-dependent accumulation of (1) 8OHdG in liver and heart, (2) 8-iso-PGF2? in heart and urine, and (3) PCC in liver and kidney. However, a 12-month resveratrol intake resulted in significant elevation of 8-iso-PGF2? and PCC in kidney. Our studies demonstrate that resveratrol treatment consistently attenuated oxidative damage in tissues where age-related oxidative damage accumulation was prominent, but also suggested that chronic resveratrol treatment may induce nephrotoxicity.
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134. Resveratrol Resveratrol And Sickle Cell Disease
Apparently, resveratrol is a very versatile natural product with anti aging properties and can also be used to treat sickle cell anemia according to a study published in the British Journal of Haematology in 2001. Volume 113, Issue 2, pages 500507, May 2001. A reprint of the abstract is shown below.
Resveratrol, a natural dietary polyphenol, has been postulated to be implicated in the cardioprotective effect of red wine and the low incidence of breast and prostate cancers among vegetarians and Orientals respectively. This compound inhibits ribonucleotide reductase as does hydroxyurea, the first therapeutic agent used in the treatment of sickle cell disease. Using the human erythroleukaemic K562 cell line as an in vitro model, we show here that 50 ?mol/l of resveratrol induced a higher haemoglobin production (sevenfold) in K562 cells than 500 ?mol/l of hydroxyurea (3·5-fold). This erythroid differentiation was linked to a dose- and time-dependent inhibition of cell proliferation associated with an equivalent increased expression of p21 mRNA, but with a higher increased level of p21 protein (sixfold) for cells treated with resveratrol than for those treated with hydroxyurea (1·5-fold). We also show that 50 ?mol/l of resveratrol and 25 ?mol/l of hydroxyurea induced variable but similar inhancements of fetal haemoglobin synthesis in cultured erythroid progenitors for the majority of the sickle cell patients studied. These inductions were linked to, but not correlated with, a variable decrease in erythroid burst-forming unit clone number. Taken together, these results show that resveratrol merits further investigations in sickle cell disease therapy.
The 3, 5, 4?-trihydroxystilbene currently named resveratrol is a natural phytoalexin present in red wine and other constituents of the human diet (Hain et al, 1990; Soleas et al, 1997). This polyphenol inhibits cyclooxygenase-1 activity and was implicated in chemopreventive action, which has been used to explain the low incidence of breast and prostate cancers among vegetarians and Orientals respectively (Adlercreutz et al, 1995; Makela et al, 1995; Jang et al, 1997; Mgbonyebi et al, 1998; Carbo et al, 1999). Resveratrol is also a radical scavenger that prevents many heart disorders by inhibiting lipoprotein oxidation and platelet aggregation (Frankel et al, 1993; Pace-Asciak et al, 1995; Jang et al, 1997; Rotondo et al, 1998). This molecule was associated with the low incidence of ischaemic heart disease observed in the French population, a phenomenon called the French Paradox. This was attributed to its presence in wine and to a moderate consumption of red wine (Renaud & De Logeril, 1993; Soleas et al, 1997). Therefore, resveratrol seems to have a very broad range of biological properties (Mizutani et al, 1998; Pendurthi et al, 1999), but little is known about the molecular basis of its activity.
Recent studies have shown that resveratrol is a ribonucleotide reductase inhibitor (Fontecave et al, 1998), much more effective than hydroxyurea (HU), a molecule that has been used clinically against a variety of tumours. HU inhibits DNA synthesis and plays a role in cell growth inhibition associated with a reversible p53-independent induction of the cyclin-dependent kinase inhibitor (CDKI) p21 (Linke et al, 1996). HU is the first therapeutic agent for the treatment of sickle cell anaemia (Charache et al, 1995), a haemoglobinopathy characterized by the polymerization of a mutated form of adult haemoglobin (HbS) leading to erythrocyte sickling which plays an important part in the disease morbidity (Bunn, 1997). Hydroxyurea has proven clinical benefit as it can increase fetal haemoglobin (HbF) levels in the red cells of sickle cell patients inhibiting HbS polymer formation (Platt et al, 1984; Charache et al, 1987; Steinberg et al, 1997; Maier-Redelsperger et al, 1998; Bunn, 1999). However, the increase in HbF is variable and some patients had only minor or no changes in HbF levels after HU treatment. The clinical benefit of HU treatment may not reside entirely in these fetal haemoglobin-stimulating properties but also in some red cell modifications, including changes in cell size, hydration and adhesion to the endothelium (Bridges et al, 1996; Hebbel, 1997; Styles et al, 1997). Nevertheless, HU had potentially short- and long-term serious side-effects and, thus, searches for new anti-sickling molecules are sought (Bunn, 1997).
Some studies have shown that the human erythroleukaemic K562 cell line produced haemoglobin with increased expression of ? and ? globin genes when treated with a variety of compounds including HU (Lozzio & Lozzio, 1975; Erard et al, 1981; Testa et al, 1982). Therefore, this cell line could be used as an in vitro model system to study the potential effects of new drugs on erythroid induction. As resveratrol possesses similar properties to HU, we compared the effects of these two molecules on the proliferation and induction of haemoglobin synthesis in K562 cells. In addition, we determined whether resveratrol could produce, in vitro, higher levels of HbF in erythroid progenitors (erythroid burst-forming units, BFU-E) than HU, from eight homozygous sickle cell patients and five healthy donors..
We are in an age where everyone is very busy and have little time to take care of their health. Yet unhealthy lifestyles can seriously effect ones health and create issues like high cholesterol and blood pressure. Modern day living leads to premature aging and people resort to various pills and potions in the hope that they can reverse the time clock. there are some products which can offer proven results such as Resveratrol which can be found in certain types red wine in great abundance.
The Red or purple grape products prevent heart problems by soothing the blood vessels permitting free flow of blood. This is the effect of antioxidants found in the skin and seeds of grapes .Especially purple grapes. The most important antioxidant know as resveratrol is found in the seeds and skin of grapes, these help in stimulating your cells and are as effective as red wine without the alcoholic effect.
Resveratrol Improves your heart
Taking red wine or resveratrol grape juice maintains your good cholesterol (HD) because it contains antioxidant such as flavonoids. Tests conducted recently by researchers concluded that the skin and seeds of grapes improves your heart such as:
Maintaining a healthy blood pressure
Protects the blood vessels
It helps in thinning of blood
Helps in maintaining low-density lipoprotein (LD), or bad cholesterol
These results based on resveratrol grape juice extract are good news for Individual who want the cardiovascular benefits of red wine. Resveratrol Grape juice can also be drunk in the form of supplements which contain prescribed amounts of resveratrol which is useful for daily consumption. Resveratrol supplements are also available in the form of pills.
It has been proven clinically by Research centers that when resveratrol grape juice is consumed as a supplement, its potency increases. This is because of the combination of many vital nutrients like Vitamin C and E along with other minerals like Calcium and Phosphorus. These healthy supplements offer some good health benefits.
Some of the benefits of Resveratrol Supplements are: Prevents Diabetes
Provides energy boost and helps control calorie intake
reduce wrinkles
There are many different resveratrol supplements including resveratrol grape juice that offers good amount of resveratrol to your body. This helps in maintaining a refreshing experience throughout the day. However these supplements do have some side effects if consumed in excessive quantities. E.g.; It has some side effects on Women who are sensitive to estrogen and who consumes resveratrol grape juice without consulting a doctor.
136. Resveratrol Health Benefits of Resveratrol May Include Fighting Fat, Study Shows
An antioxidant found in red wine and grapes known as resveratrol -- which already keeps the heart healthy and ward off cancer -- may also turn out to be a fat fighter, according to new research.
In the laboratory, exposure to resveratrol prevented pre-fat cells, termed pre-adipocytes, from increasing and from converting into mature fat cells, according to Martin Wabitsch, MD, PhD, a researcher from the University of Ulm in Ulm, Germany. Wabitsch presented the findings in June 2008 at ENDO 08, The Endocrine Society's 90th annual meeting in San Francisco.
"We have to show it works in the same way in human beings," Wabitsch says.
The hope, he says, is to continue the research and, if it bears out, develop drugs that will use the same mechanism as the resveratrol in controlling the fat cells.
Health Benefits of Resveratrol: Study Details
In previous research, Wabitsch and his colleagues had found that the resveratrol protected lab mice fed a high-calorie diet from the health problems brought on by obesity by mimicking the effects of caloric restriction.
So the next step, they thought, was to see if the substance could mimic the effects of caloric restriction in human fat cells by changing them.
"We used a human fat cell strain," Wabitsch says, a stable cell strain that can be used over and over in the laboratory.
They exposed some fat cells to resveratrol and did not expose a comparison group of fat cells to the antioxidant. "Forty hours is the normal doubling time [of pre-fat cells]," Wabitsch says. "At 48 hours, the pre-fat cells in the control dish had more than doubled. In the resveratrol dish, the number of pre-fat cells had decreased by 40% to 45%,"
The volume of fat cells exposed to the resveratrol was also less, he says, in effect producing skinnier fat cells. Exposure to the resveratrol also reduced the secretion of substances called interleukin 6 and 8, which may be linked to the development of diabetes and clogged arteries, both thought to be obesity-related problems.
Wabitsch says the finding is consistent with the theory that red wine's resveratrol explains the so-called French paradox -- the observation that French people, who eat a relatively high-fat diet but enjoy their red wine, have a low death rate from heart disease.
Health Benefits of Resveratrol: What's the Mechanism?
Resveratrol affects the fat cells in many ways, Wabitsch says. "There's not just one mechanism."
"The reduction of the number of pre-fat cells works through SIRT1," says Wabitsch, referring to the activation of a gene associated with metabolism and aging.
When they "silenced" SIRT1 in animal studies, the resveratrol had no effect on the proliferation of the pre-fat cells, he says.
The study was partly funded by the German Research Association and the Ministry of Science, Research and Arts in Germany.
Resveratrol turns on genes involved in bone formation and turns off genes involved in bone destruction. The result is the conversion of precursor bone cells to bone-forming cells (osteoblasts), as well as the inhibition of the production of bone-destroying cells (osteoclasts). The net result in bone is anabolic. In other words, the bone is getting stronger with an increase in bone mineral and bone structural components or proteins.
You have probably run across Resveratrol while searching for the perfect health supplement. However, is the word is unfamiliar below is a brief synopsis..
Resveratrol is a well-loved antioxidant that is common among plants. Its major sources include grapes, mulberries, raspberries, cranberries blueberries, peanuts, Japanese Knotweed and in some pine trees. It is actually an antibiotic designed to fight bacteria and fungi. In general, antioxidants protect living things against harmful environmental elements such as free radicals, a set of molecules which damage the DNA.
However, if you dont have access to wines or if peanuts and grapes are too expensive in your area, Resveratrol comes in pills and capsules and juice form today,. They are sold as vitamin supplements, so you wont have trouble purchasing them over the counter. The Resveratrol content in such pills are equivalent to 4 ounces of red wine, sans the alcoholic effect. Resveratrol is recommended for senior citizens.
The studies regarding Resveratrol trail blazed when the French paradox (high calorie diet + high fat diet + red wine = low incidents of heart disease) was discovered. A lot of people believed that the small number of heart diseases in France despite of their lifestyle was caused by red wines protagonist: Resveratrol.
Resveratrol is known to fight a lot of mans problems. Modern findings show that it is effective in fighting certain diseases and discomforts such as aging, heart disease, menopause, inflammation, gastrointestinal diseases, breast cancer and even osteoporosis.
Osteoporosis and Resveratrol
Resveratrol, according to another recent laboratory study, has the potential of helping to prevent osteoporosis without the health risks associated with HRT. Demonstrating that this plant compound is a phytoestrogen, which can bind to and activate estrogen receptors, was the impetus to investigate the potential role resveratrol may play in bone metabolism.
Studies were carried out in cell cultures as well as animals that were susceptible to bone loss (ovariectomized rats). Collectively, the results demonstrated a number of bone-forming activities associated with resveratrol treatment.
Resveratrol turns on genes involved in bone formation and turns off genes involved in bone destruction. The result is the conversion of precursor bone cells to bone-forming cells (osteoblasts), as well as the inhibition of the production of bone-destroying cells (osteoclasts). The net result in bone is anabolic. In other words, the bone is getting stronger with an increase in bone mineral and bone structural components or proteins.
138. Resveratrol Resveratrol has been dubbed as the most potent antioxidant of the 21st century and has received much commend since studies released in 2006 indicated its health benefits. Many have queried whether it can repress cancerous cells and resveratrol and prostrate cancer cure have been linked many times.
A study conducted at Alabama University on Resveratrol fed mice showed that Resveratrol slowed the cell division within the tumors and thus inhibiting the growth and spread of the tumor. Resveratrol fights cancer by regulating the sex steroid receptor and growth factor signaling pathways. Mice on Resveratrol were 8 times less likely to develop differentiated prostatic tumors.
Furthermore, Resveratrol increases androgen receptors (a key component in maintaining the male sexual phenotype), and Insulin-like growth factor 1 receptor (a receptor that plays an important role in growth of muscle cells and regulation of body mass).
Aside from these changes, Resveratrol did not do anything to harm the homeostasis of the prostate making it one of the less invasive solutions for fighting cancer (however Resveratrol does not cure prostate cancer, it only helps prevent and slow the progression of said cancer.)
Source:-
Oxford Journals
Life Sciences & Medicine
Carcinogenesis
Volume28, Issue9
Pp. 1946-1953
This news is excellent as prostate problems is one of the most common cancers in men similar to breast cancer in women and the linkage between resveratrol and prostate trouble is really exciting indeed.
Resveratrol can be found in many dark skinned fruits such as red grapes, cranberries, blueberries and raspberries
The results of contemporary testing have produced great results so it would seem prudent for men in the over fifty age bracket, the likeliest to suffer because of this form of cancer, to consider taking a resveratrol supplement. In fact as resveratrol has plenty of other health benefits such as fighting diabetes, reducing the aging process, helping to reduce wrinkles and age spots and boosting energy itd be a good supplement to take simply for improving over all health whatever your age and gender.
Since its discovery in the 1960's Resveratrol has been regarded as the latest super drug and many people are convinced that it may hold the answer to staying appearing younger for longer.
Their have been significant claims for Resveratrol which may have been over hyped as the result of the business owners lust for business, but what shouldnt be ignored is that many people have claimed unbelievable results. However I feel it is essential to address a series of questions which have been directed at resveratrol (nutritional supplement) and in this article I will attempt to reveal some of myths and put to bed some untruths.
Can Resveratrol actually work to prevent cancer?
I am sure it will surprise no one to know that incidents of cancers are on the increase and even with the great number of scientific breakthroughs. As long as we continue our current life style choices and diets it is most unlikely to be declining any time soon.
Resveratrol has been successful in fighting cancer in lab mice however at this time very minimal evidence to infer this may also be the effect in humans.
Resveratrol Research In To Aging
There is almost certainly more information to demonstrate that Resveratrol can be effective at improving heart function and reduce the risks of heart disease and heart attacks.
There is compelling evidence to suggest that resveratrol does benefit the circulation of blood around the body and helps prevent blood clots and blockages of the arteries.
Can Resveratrol extend your life expectancy?
There has been quite a number of experiments carried out on several animal species which have given encouraging results and help indicate that there is a likelihood that Resveratrol may possibly extend life in humans.
Most initial research carried out has been on fish and these results have been very encouraging but similar tests on mice have not been so exciting. However more testing is ongoing and many scientists are excited that Resveratrol may hold some hope of prolonging life and slowing down the aging process.
Can Resveratrol Supplements give additional energy levels?
Resveratrol obtained most often from Japanese Knotweed (a grass found in Japan) is stated by many men and women to have given them an extra energy boost.
It is a possibility these claims derived from a naturally occurring plant with no known major side effects that has lead to most of the excitement associated with Resveratrol.
It has been shown that with out doubt Resveratrol is exciting anti oxidant and this helps get rid of the free radicals which are produced as part of the usual aging process and also by pollutants in the air. It is this that is believed to help us feel more energized and may also perform some part in slowing down the aging process.
Can Resveratrol fight the aging process?
No looks forward to growing old and many are looking for for the fountain of eternal youth but does it exist? Its obviously impossible to stop the aging process and stay a young man or woman for ever but many scientists believe that Resveratrol could help slow down the aging process. This may be on the whole due to its action in eliminating free radicals but the real reason is still shrouded in mystery and many people are now taking Resveratrol knowing that even though it may not hold the secret of everlasting youth they have noticed some significant health benefits. and signs such as reversal of greying hair.
Resveratrol is a compound most often found in the skin of red grapes and was brought to the attention of scientists in the 1990's when it was perceived that French people who love red wine appeared to have lower than average heart disease, despite eating a relatively high fat diet.
Other sources of resveratrol
Plants such as eucalyptus, lily and spruce and other foods such as peanuts and mulberries contain small amounts of Resveratrol but nothing like the concentration in the skin of grapes such as labruca and muscadine which contain up to 100 micrograms per gram.
Resveratrol is an antibiotic compound and fights disease such as fungus, thus when wine is fermented the amount of resveratrol increases.
Cardiovascular Effects
There have been a number of studies completed which demonstrate that a glass of red wine a day is good for you as it may reduce coronary heart disease.
Anti-Aging" Effect
Recent studies in laboratory mice have found increased survival and lower incidence of several diseases and conditions associated with aging.
Cancer-Related Effects
Resveratrol is being studied to see how it affects the initiation, promotion, and progression of cancer. With regard to tumor initiation. Resveratrol was effective against tumors of the skin, breast, gastrointestinal tract, lung, and prostate gland of animals, a recent review concluded: by Bishayee A. Cancer prevention and treatment with resveratrol: from rodent studies to clinical trials. Cancer Prevention Research 2:409-418, 2009.
There are currently a lot of pills, powders, and shakes out there that are promising to be the one true way for you to finally win the weight loss challenge. But the fact is that most of these products do not work and if they do, most people realize that they may not work for everyone. What may work for the guy down the street may not really work for you so it is about finding what will be the right solution for you. For a lot of people, what works is a cardio exercise weight loss program.
While there are different types of cardio exercise weight loss programs out there, they are all basically the same. Cardio is cardio when it comes down to it and if your cardio exercise weight loss program is something that you like and something that works well for you, then keep up the good work, as it will all pay off in the end. Any fat loss workout plan that follows the basic health guidelines is a workout plan that can work. But you do want to make sure to speak with your doctor first if you are suffering from any health problems in case a particular cardio exercise weight loss program is not right for you.
Finding The Right Weight Loss Plan
As mentioned before, not every plan is right for every person because we are all made differently. Every body is different therefore every workout plan will not work for each person out there in the world. Sadly, there is no way to determine up front which one will be the one that is right for you and will provide you with the results that you desire. So you simply have to pick a cardio exercise weight loss program that looks good to you and start with that and work on it for a while.
If you do not start to see results within a few weeks, you may want to think about switching over to a different cardio exercise weight loss program. Remember though, you must be expecting realistic results because just because you do not drop twenty pounds in two weeks, it does not mean the program is not working. The average healthy amount to drop in pounds each week is two on average and this is a result of healthy eating and an exercise routine. Do what is right and you will get results that can last you a lifetime.
Supplement is a word defined by Webster as such: Something added to complete a thing or to make up for a deficiency. Even so; some weight loss supplement companies market their products as magic pills and some consumers think of them as such.
I believe weight loss supplements can be beneficial if we learn to look past the hype and use them in addition to improved eating habits as well as increased physical activity.
Know what you want out of your weight loss supplement:
Are you looking for decreased appetite, carb blocking ability or increased metabolism? What is the manufacturer promising? What are the active ingredients and what studies and dosages were done on them?
Look for reviews and testimonials:
This is something I almost did not want to mention because reviews and testimonials can be very conflicting. Reading weight loss supplement reviews and testimonials is going to require you to think for yourself and determine if the review or testimonial makes a valid point or not. I recently read a review for a weight loss product that said something to this effect: I did not like this product; I continued to eat the way I always do and actually gained weight on this product. My interpretation of this is that the person probably did not carefully monitor what they were eating. They were gaining weight before eating what they normally eat and were expecting this pill to magically cause them to lose weight. On the other hand, a weight loss testimonial that says I eat anything I want and am still losing weight! is equally suspicious to me. Weight loss product testimonials and reviews can be helpful in your decision if you weed through the hype and incomplete information. Look for clues such as: Did this product decrease the customers appetite? Did the customer experience more energy? Was the reviewer jittery?
Is it too good to be true?
We have a tendency to believe what we want to believe. But when it comes to weight loss supplements we have to be honest with our self. Are the claims exaggerated? Is the company telling us we do not need to change our lifestyle? Does it appear the company wants us to lead a healthy lifestyle or does the company want to sell millions of pills? Remember weight loss supplements are going to help you reach your goals, not carry you to the completion of your weight loss goals.
Best seller does not always mean the best product.
I was a distributor for a branch of a very reputable supplement company and attended a convention they sponsored. The speaker was talking about making claims when trying to sell product and how they did not want us making any claims that have not been backed by science. Someone asked the question about other companies and why they could make outlandish weight loss claims and experience such great sales while we could only state scientific fact. The speaker acknowledge the fact that these companies would sell millions of dollars worth of product but they would not earn repeat customers and more than likely would not even exist in the long run. Ask yourself if the product you are interested in is a best seller because of hype or because the company is reputable and has a quality weight loss product.
Has the company been around for a while?
While the fact that a company is new does not mean it is low quality, a company that has been around for years usually has happy customers.
Read the directions and warnings very carefully.
I knew a lady that was taking a Chitosan product and getting sick. She asked me about it and I quickly asked her if she was allergic to shellfish-She was. Fortunately for her it was only a mild allergen and she did not suffer seriously. It was clearly stated on the label; Do not take if you are allergic to shellfish. Also dont have the mentality that if one pill is good then two must be better. Natural weight loss products can be very powerful and should be treated with respect.
Take a break from time to time.
Occasionally take a break from your weight loss supplement regimen especially if you are using a weight loss product that contains a stimulant such as caffeine or other powerful herbs. I even do this with my multi-vitamin. I just believe it is a good idea to give your body a break from time to time.
Conclusion:
I believe weight loss supplements can help you reach your weight loss goals, I also believe you can reach your weight loss goals without weight loss supplements, however I have always been the type of person that wanted every edge I can get. So if you are like me, and you decide to use weight loss supplements, think of your weight loss goal as a three legged table. One leg represents healthy eating, one leg represents activity, and the other leg represents your weight loss supplementation. Remove any one leg and the table will fall. Rely on only one leg and you will not reach your weight loss goal. Shop carefully, have realistic expectations, follow safety guidelines and reach your weight loss goal!
When looking for the best weight loss pill available in the market nowadays, you can consult your doctor or drop by a drugstore and ask a pharmacist. Whatever type you choose, remember that the best weight loss pill should be able to help you lose those unwanted pounds with very little or no side effects.
The best weight loss pill groups can be divided into the following categories: prescribed or over-the-counter.
1. Prescribed weight loss pills are clinically tried and tested to produce results that they claim to provide to users. These are also approved by medical organizations to ensure that the drug really works according claims. Their side effects are known and studied. Furthermore, they are usually given to those who are suffering from severe weight problems like obesity.
2. Over-the-counter weight loss pills are those you can buy directly from the drugstore or your local pharmacy. Some of them are generic, which you should be careful in taking because some have excessive amounts of toxins that can be harmful to the body. OTC weight loss pills do not support their claims. It is highly recommended to purchase OTC weight loss drugs that are popular or have known success rates among those who have used it.
Natural ingredients
Perhaps one of the biggest misconceptions in weight loss is that natural and herbal ingredients are entirely safe. Keep this in mind when buying the best weight loss pill. Ephedra is an example of a popular natural fat burning ingredient until the FDA found them to be dangerous to the heart and the nervous system.
The action
Judge a weight loss pill based on what it can do to hasten weight loss. There are several types of weight loss pills like fat blockers, fat burners, and appetite suppressants. All of these can be in the form of prescription drugs, OTC drugs, or even from natural ingredients.
1. Fat burners these types of weight loss pills effectively help the body in breaking down fats coming from food intake. Once the fat cells release the fat, it enters the bloodstream in the form of free acids that will go to muscle cells where they are going to be burned.
2. Appetite suppressants these are very popular because they take away your desire to eat to prevent you from unnecessary bingeing and overeating. Examples of prescribed appetite suppressants are Phentermine, Acomplia, and Meridia.
3. Fat blockers these gained popularity among users because they are safer and have healthier effects compared to other weight loss drugs. Popular examples of this type are Alli, Chitosan, Proactol, and Xenical. Fat blockers prevent fat from affecting lipase enzymes that are responsible for absorbing fats from food intake. However, side effects include diarrhea, oily stool, and abdominal discomfort.
Do you want to learn how to lose weight easily? It can be confusing with hundreds of different diet companies pushing their product down your throat. The diet industry makes billions of dollars a year for a good reason. If most diet plans actually did work, the diet companies wouldnt have to keep on pumping out new products. I will explore with you why many diets do not work and show you the one diet that does.
The Reason Why Most Diets Fail
If you have tried diets that restrict your caloric intake or the carbohydrates in your diet, (like the Atkins or South Beach diet), you were probably happy to find that you lost a few pounds. Unfortunately, this was probably initially and then you rather gained the weight back or reached a point where you didnt lose any more weight. The reason why is that when you deprive your body of much needed calories, your body will slow down your metabolism and try to store all its resources. Low-carbohydrate diets can in addition worsen carbohydrates cravings, besides slowing down your metabolism and result in weight regain.
Feeling tired?
Restricting your caloric intake also leaves you feeling tired, lethargic and drained of energy. As mentioned above with carbohydrates, when you limit food groups you are removing important vitamins and minerals from your diet. Going on a liquid or grapefruit only diet will harm your body in the long run. For example your thyroid may be affected when you deprive your body of nutrients like zinc, magnesium and protein. Some dieters experience hair loss, organ failure and even heart attacks.
The Correct Way
If you want to learn the correct way to losing weight, it should be clear by now that starvation is not the way to go. One of the most popular and the secret to how to lose weight easily is calorie shifting. It promotes the consumption of a variety of foods, and encourages you to eat 4 meals a day or more. The premise behind this is that your metabolism is increased with the consumption of a variety of foods and that by constantly eating, your body burns calories at a constant pace. Visit the link at the end of this article to learn more about calorie shifting.
Move!
Besides being on the right diet you should start exercising at least 4 times a week for at least 30 minutes a day. A combination of exercise coupled with calorie shifting will properly help you burn fats fast. What are you waiting for? Move your BUT!
Odds are you already know everything you need to know about weight loss. Still, you could work up a serious appetite just thinking about all the weight loss advice available to consumers. The answer is not necessarily to learn every new concept about losing weight, but to find one that motivates you.
Here are 10 of the simplest tips to help you lose weight:
The best weight loss advice helps you eat fewer calories than you burn so you store less fat.
Be skeptical of fitness ads promising rapid weight loss or fat loss from specific body parts.
Use food labels to your advantage.
Losing weight requires eating slightly less than you body needs every day. For most of us, that means eating a lot less than you want.
Dont wing it. Create a personalized meal plan that you can actually stick to.
Assess your unhealthy eating habits and commit to change one at a time. Slowly but surely.
Dont try to be perfect. Be consistent. Be smart. Be flexible.
When creating a weight loss plan dont forget about setbacks and maintenance.
Get professional help if you need it. (From a Nutritionist, Weight Loss Coach or Psychologist.)
The biggest weight loss secret is that there are no secrets. :-)
Health and Wellness - Weight Management Fact and Fiction
Knowing the truth about losing weight can help you separate what works from what doesnt. Dont be taken in by expensive wieght-loss fads like pills, herbs, and special foods. Theres no magic way to lose weight. If you have questions about weight loss, ask your health care provider.
Fiction: The faster I lose weight, the better.
Fact: Rapid weight loss is usually due to loss of water or muscle mass. What you are trying to get rid of it extra fat. Aim to lose one-half to 2 pounds a week. Then youre more likely to lose fat rather than water or muscle.
Fiction: Skipping meals will help me lose weight.
Fact: When you skip meals, you dont give your body the energy it needs to work. Hunger makes you more likely to overeat later on. Its best to spread your meals throughout the day. Eat at least 3 meals a day.
Sorry to say there are no magic bullets.
There is one tried and true strategy however.
The internet is filled these days with promotions for diets, quick weight loss items, Hoodia, ephedra etc. etc. etc. The list goes on and on.
Some of these products may even work for you. But what I know is the secret to dieting and weight loss is to watch what you put in your mouth.
If you consume 2000 calories and expend only 600 you have an excess. It isnt rocket science. That extra portion of supper, that donut at mid morning, that soft drink and candy bar in the afternoon. They all add to the caloric intake.
While it isnt rocket science it is very hard. You have to be in the right frame of mind, you have to have support, you have to be ready and want to watch what you eat.
Without that you are wasting time, effort and money. So the first thing you need is a plan and the commitment to lose weight. Once you have that your success is not far behind.
Continuing on from Yesterdays post -
Using a good jogging training program has worked with various people and objects. Walking workouts allow users to not only lose weight, but also allows users to keep losing weight. protein loss wheel weight achieved exercise on foot, almost all age groups and individuals, the level of activity. It helps people lose weight and maintain weight loss on the treadmill exercise routine. proper nutrition, healthy, and are intended to help users unwanted pounds of weight loss, is carried out in collaboration with the training.
Walking exercise weight loss, so that the user to walk or jog in walking for a certain period of time and at least 5-6 days a week. Walking workouts weight loss requires that the user spends 45 or more minutes per session on the walking machine. Consistency in the preparation of protein-wheel drive is the key to successful weight loss jogging. Initially, weight loss workout tape starts nice and easy pace, but with time the intensity and duration of training was increased to achieve weight loss efforts. For visitors walking exercise weight loss remember that moving your body all the time, and as fast as they can remain comfortable. More rapidly during exercise treadmills to lose weight in the Walkers, and burns more calories will ultimately lead to weight loss. Regular exercise to increase metabolism and improve weight loss tapes.
Treadmill weight loss is the best way to lose weight give users plan their workouts in the messengers, and make it a daily habit. Maintaining consistency in training is key to successful weight loss tapes. Walking weight loss tips during training to walk on treadmills include maintaining correct posture, posture, relaxation of the neck, arms swinging with one hand, participation in the belly to your hips free and relaxed and focus on your breathing. Walking weight loss tips listen to music, watching TV or chatting with a friend at your side, to avoid boredom in a normal weight loss training.
Health and Wellness - Exercise and Weight Loss
A healthy body image is a body that is not only at ideal weight but also proportional weight and shape. Ideal body weight makes the body look healthy and a healthy body is then a body that looks fresh and fit. Actually, getting a healthy body is not difficult. It can be obtained through exercise . In addition, it should be followed by proportional diet with balanced nutrition.
In urban areas, especially in many big cities, there are many more people with excess weight rather than in rural areas. This is due to lifestyle that is not appropriate and lack of exercise. Less physical activity and bad eating patterns cause excessive weight or even obesity. The safest way for people suffering from excess weight is to exercise to lose weight. The combination of exercise loss weight and healthy diet can lose weight significantly. However, it depends on the condition of the body and illness history.
For those of you who your bodies are overweight or even obese, you may follow a program of exercise to lose weight. The programs of exercise l can be easily found and done in the gym, fitness centers, and health clubs. Basically, weight loss can be achieved with specific and regular exercise 2-3 times in a week. Any sport activities that can be done for exercise loss weight include jogging, running, tennis, aerobics, swimming, and cycling, or even yoga.
Sport activities are the application of exercise to lose weight. In daily life, exercise to lose weight can be done anywhere and anytime. It means that exercise does not require a special place and time. It can be done when you go to the office, go home or shopping to the supermarket. You can get to your office by walking or cycling. According to the result of health research, walking or cycling can burn calories effectively in the body. Walking for 15-20 minutes, can burn the calories up to 200 calories. Meanwhile, cycling for 30 minutes can burn calories as much as 200-300 calories. For those of you who want to lose weight, it is recommended to do exercise loss weight with proper exercise that suit to your body.
Have you ever thought what is the right weight for my height? or what is my ideal weight? Well, there are many factors to making an accurate and informed decision about these questions. Factors such as frame size, age, and gender are just a few variables that affect your correct weight and height recommendations.
Before setting your weight loss goals or beginning a diet, we suggest that you learn more about height weigh tables and charts but do so with a sense of gentleness, for this information is meant only to guide you. And do yourself a favor as you explore weight and height information and remember that there are many wonderful, beautiful body sizes and shapes including yours.
Summers here! Grilling out. Beer by the lake. Outdoor concerts. Lots of opportunities for guys to take their shirts off and for girls to wear short-shorts. Yeah hows that gonna work for ya? Youve probably got a dozen different ways of how to cook steak but not one best way to lose abdominal weight. And you know what? Its easier than you think.
The exercises to lose weight quickly are NOT those 90-day boot camp things advertised on TV. But they arent all those machines and gizmos either. And if youre thinking what about foods that can help me lose weight? The truth is: EVERY food can help you lose weight OR gain it.
So what are you supposed to do? How can you get in shape for summer?
1. Start now. Cutting weight is for boxers, wrestlers, and people kicked off The Ultimate Fighter.
2. Get in shape with knowledge. Look, just because some B list movie star can get a magazine cover shape with 3 trainers and 8 hours of exercise a day doesnt mean you can. BUT you CAN get that shape a lot easier if you do it with knowledge (seriously. Dont you think youre smarter than those yahoos anyway?).
3. Approach it comprehensively. What you eat ties in with how you exercise ties in with how you work ties in with your emotions So get an approach that recognizes this, and doesnt try to cram all your fitness into 5 meals and 10 minutes of exercise a day.
People spend so much time and effort to find supposedly the best fast weight loss diets, so they could lose weight successfully and live a better life. But every person that wants to, sees that diets are not very effective at all. For some reason we are lead to believe, that diets are the answer to weight loss, so no-one even bothers to question, if that is true or not.
A ordinary person has the idea that, if he or she wants to lose weight, then a calorie deficit is needed. Eating less food is the best way to create that needed deficit and that is somewhat true. But if we take a closer look, then we can cracks in this theory.
Most diets out there, that are supposedly the best because they make people lose weight fast, require people to cut their calorie drastically and to very low levels. Which can be as low as 800 or less calories for women and 1500 or less calories for men.
Now every time that calories are reduced drastically fast weight loss will occur, so in that sense diets do work very well. But as you know this fast weight loss, does not last very long. There are very good reasons, why it does not last.
If you starve yourself with diets to lose weight, then your body can not separate a diet from starvation. They are both the same, so the response is also the same. This means fat burning hormones and enzymes decrease, fat storing enzymes and hormones increase, the metabolism slows down, hunger increases etc. All of these things happen, because your body is trying to protect you from starving yourself to death.
Although diets do work temporarily, they can´t work successfully in the long-term. It is impossible to out smart the body, so there really is no best fast weight loss diets, that work. I believe that everyone, including you, wants permanent results and permanent results, can´t be achieved with temporary methods.
Why exactly do you want to lose weight? There are tons of motivations why people want to get rid of their excess pounds what is your motivation? What is motivating you to seek out information to lose weight quickly? You are reading this for a reason thats personal to you. You didnt happen to stumble upon this article accidentally. So, let me try to help you.
Did you make a New Years Resolution to lose weight this year? Maybe you started off pumped up, focused, like Yeah, THIS time Im really gonna do it, finally. You start envisioning what youre going to look like after youve lost your weight, new smaller sized clothes you can buy, or just being able to fit into those clothes gathering dust in your closet. But .it didnt last.
Maybe youre one of us that realize that time is running out before the warm weather hits. Crap! I cant wear sweats to the beach! I love summer, but my bodys not ready theres no way I can fit into my summer clothes right now help! I need to lose weight and I need to lose it NOW!!
Do you have a wedding just around the corner and you want to lose those last 5, 10 or whatever pounds? Could be you have a social gathering, or some special function coming up that you want to look and feel your most desirable.
One of my reasons is that my 60-something metabolism is slowing down and what used to work to lose weight, not so much now. I also want to change my eating habits that turn into a lifestyle and not a succession of yo-yo or fad diets to achieve my weight loss goals. And I definitely dont want something fussy who has time for that?
Do you need to find something to jump start your metabolism, naturally, too no matter your age or gender?
Ive only mentioned a few of the vanity (yes, I admit Im vain I wanna look good and feel good) reasons for losing weight. Each person has their own, personal, motivating factors as to why they want to get rid of dare I say it that ugly, nasty, body fat that stares at us in the not-so-friendly mirror.
There are real, serious health reasons to want to lose weight, too. That would be a whole new article and then some. Even at the simplistic level, an extra 5 lbs puts an enormous amount of stress on your bones and joints:
"Being overweight, even just moderately, impacts weightbearing joints and can increase the pain of
arthritis. Research has shown that during walking the hips, knees, and ankles bear three to five times a persons total body weight. For every pound a person is overweight, three to five pounds of extra weight is added to each knee during walking. In contrast, a ten pound weight loss causes 30 to 50 pounds of extra stress to be relieved from the joints. " (http://arthritis.about.com/cs/diet/a/extrapounds.htm)
Dont you too, want to lose weight fast have more energy better your health learn how to burn fat better and just feel better about yourself? After a lot of research, Im getting ready and excited to start a journey thats going to help me and a lot of you reach our weight loss goals finally! Think you can do it?
The Increasing rate of obesity is a becoming a worldwide problem. We are constantly surrounded by advertisements for fast food restaurants and to buy food that will eventually kill us. The sad fact is that the USA is the fattest country. Like you and most Americans we would like to be healthy, slim and live a long productive life.
This is not a hard concept to accomplish losing weight can be very easy if you are willing to put forth the energy and willingness to complete your initial goal. There are a steps that you can do everyday to lose that unwanted weight that you dont want or need. Here are 4 steps that you can do to rid that excess weight.
1. Eat a low calorie diet~stay away from fast food, i know its amazing and it taste so so good, but it is one of the biggest contributors to weight gain. Cutting out fast food or limiting how much of it you eat can make a drastic impact.
2. Eat Only 4 Times a day~ Limiting yourself to 3 meals and a snack will lower the amount of calories to the point where you are eating enough and not to much. Eat a medium size breakfast, it is the most important meal of the day it gives you the energy you need for the day. Eat a small lunch i.e. a salad and some fruit. About an hour or two before dinner have yourself a snack. An apple or banana would be perfect. Keep it healthy. Dinner eat food with carbohydrates like noodles.
3. Exercise~ keeping active will cause you to lose weight. Most of the time people eat then sit in front of the T.V. That will Definitely be a huge factor in weight gain, but you are trying to lose weight. So go for a walk around the block, take your dog or significant other or just a friend and walk around for a half hour or so. It will make a huge difference walking for a half hour than sitting watching T.V.
4. Keep Hydrated~ Drink less coffee, soda and energy drinks the sugar content in those will definitely cause weight gain, plus they dehydrate you. Water or Gatorade will help you lose the weight and keep you well hydrated which in turn it will keep you full of energy that you need to live an active life.
Losing weight doesnt have to be a losing battle it can be done, very quickly to. There are many ways to get to the size that you want to be at. You just have to have the ambition to get there. There are many products and books out there that you can buy that will give you step by step instructions on how to lose weight quickly. All you have to say is that I want to lose weight, and nothing is going to stop me!
According to a report published in UK, a third of adult and a fifth of children will be facing the obesity problem by the end of 2010. This will result in more people suffering from related health problem like cardiovascular disease or type 2 diabetes associated with obesity. The Government will have to spend a major portion of its budget on its health care programs. The Government will do its duty. However it is also the responsibility of individuals to fight with the problem at their own. What can they do?
People will have to change their life style to combat the obesity problem. They will have to make their daily routine disciplined. They will have to change their luxury habits. They will have to learn to walk on the foot. They will have to do daily physical exercises. They will have to give up junk food. They will have to make it their habit to eat fresh food cooked in their kitchen. They may have to use weight loss supplements.
Neither any weight loss supplement nor any single exercise is alone capable of fighting with the obesity problem. A concrete well planned weight loss program will have to be adopted. Firm determination will be required to follow this program. Sit ups and other stomach exercises may tone up the stomach muscles below the layer of fat. But you will have to diminish this extra body fat to get the slim and healthy body.
To achieve the aim of getting toned flat stomach in place of your beer belly you will have to change your habits of eating, drinking and training habits. Unfortunately there is no miracle weight loss supplement is available in the health stores that can do away with your extra weight, while you are lying on the bed. You, yourself will have to do something. You do not need to do too much hard work. You will have to make some simple alterations in your daily routine.
What are these alterations, you need to make in your life? These are combining cardio exercises like walking, swimming and running in your daily routine. You will have to do some abdominal exercises. You will have to take controlled but balanced diet. You may need some effective weight loss supplement to compensate for the energy you spent in your long workouts.
In fighting obesity problem, the most vital role is of that of food. Habit of excessive eating increases the body fat and thus weight. Our body requires much less than we eat. By eating too much, we overload our metabolism system unnecessarily. The excess energy is stored in our body as an extra fat. We have given up the habit of working hard and spending the energy intake of the body. We tend to use weight loss supplements to lose this extra fat.
Often you have to do a little to get rid of increasing weight if you start at the right time. You need to do some workouts in the gym and some simple exercises at your home. These simple exercises include walking, jogging, cycling and some sit ups.
